About the GeneConvene Virtual Institute

The GeneConvene Virtual Institute aggregates, curates and shares knowledge to advance understanding of genetic biocontrol technologies, such as gene drive, as well as selfish genetic elements found throughout nature.

The Virtual Institute is an initiative of the GeneConvene Global Collaborative, a program within the Foundation for the National Institutes of Health that advances best practices for genetic biocontrol technologies such as those using gene drive.

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Comparing the long-term persistence of different Wolbachia strains after the release of bacteria-carrying mosquitoes

Jose L. Orozco-Gonzales, Antone dos Santos Benedito, Daiver Cardona-Salgado et al.,  Mathematical Biosciences,  372. 2024.

This paper proposes a bidimensional modeling framework for Wolbachia invasion, assuming imperfect maternal transmission, incomplete cytoplasmic incompatibility, and direct infection loss due to thermal stress. Our model adapts to various Wolbachia strains and retains all properties of higher-dimensional models. The conditions for the durable coexistence of Wolbachia-carrying and wild mosquitoes are expressed using the model’s parameters in a compact closed form. When the Wolbachia bacterium is locally established, the size of the remanent wild population can be assessed by a direct formula derived from the model. The model was tested for four Wolbachia strains undergoing laboratory and field trials to control mosquito-borne diseases: wMel, wMelPop, wAlbB, and wAu.

As all these bacterial strains affect the individual fitness of mosquito hosts differently and exhibit different levels of resistance to temperature variations, the model helped to conclude that: (1) the wMel strain spreads faster in wild mosquito populations; (2) the wMelPop exhibits lower resilience but also guarantees the smallest size of the remanent wild population; (3) the wAlbB strain performs better at higher ambient temperatures than others; (4) the wAu strain is not sustainable and cannot persist in the wild mosquito population despite its resistance to high temperatures.

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Antiviral Wolbachia strains associate with Aedes aegypti endoplasmic reticulum membranes and induce lipid droplet formation to restrict dengue virus replication

DENV-1 Titer Impacts Viral Blocking in wMel Aedes aegypti with Brazilian Genetic Background

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