Science Digest
Summary and analysis by subject matter experts
Gene Drive: Engineered viruses take on their own kind in a new studyRizwan Choudhury, Interesting Engineering, 2023.Scientists are exploring a radical idea to combat viral infections: use viruses against themselves. They are testing whether introducing modified viruses into people with the same natural viruses can spread a gene that destroys the infection. This has yet to be done successfully ... Keywords: CRISPR, Gene drive, HSV-1, viral infections |
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Meeting Abstracts from the 5th B Chromosome ConferenceAnonymous, BMC Proceedings, 17. 2023.During preparations for the 5th B-Chromosome Conference (5BCC), rapid and significant progress was observed in the germ-restricted chromosomes (GRCs) study. GRCs are additional chromosomes found only in germ cells and are eliminated from somatic cells in many avian and dipteran ... Keywords: CRISPR, Gene drive, HSV-1, viral infections |
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A Multiple Gene Drive SystemFerdinand Nanfack Minkeu, IGTRCN, 2019.Yan & Finnigan, (2018) recently published a paper in Scientific Reports describing an artificial multi-locus gene drive system by using a single Cas9 and three guide RNA (gRNA) in the budding yeast Saccharomyces cerevisiae. Nuclease-based gene drives do not follow the typical ... Keywords: CRISPR, Gene drive, HSV-1, viral infections |
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Multiplexing gRNAs to Hedge Against Resistance to Gene DriveTravis Van Warmerdam, IGTRCN, 2018.Recently, Oberhofer et al (2018) published a paper examining the mechanisms of homing endonuclease gene drives in The Proceedings of the National Academy of Sciences. They used a novel nuclease-encoding cassette containing four multiplexed gRNAs targeting genes required for ... Keywords: CRISPR, Gene drive, HSV-1, viral infections |
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Cas9 Gene Drive, Sex-Conversion and Evolved ResistanceAnna Buchman, IGTRCN, 2018.In a recent manuscript, KaramiNejadRanjbar et al. demonstrate the development of a proof of principle Cas9-based suppression gene drive in D. melanogaster that can be applied to pest insects, and discuss the implications of resistance allele formation for practical use of such a ... Keywords: CRISPR, Gene drive, HSV-1, viral infections |
Contact
David O’Brochta
Foundation for the
National Institutes of Health
geneconvenevi@fnih.org
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