In 1974 Aedes aegypti with chromosomal translocations engineered in the laboratory were mass produced and released in Chibarani village in coastal Kenya.
Insects with rearranged but otherwise complete genomes (translocations) can be perfectly viable
However, most of their progeny will die because of the absence of parts of the genome and/or over abundance of others (deletions, aneuploidy)
Introduced sterility into the Chibarani population was extensive.
This study emonstrated the effectiveness of introducing translocations into a field population of A. aegypti to suppress populations.
Tags:Aedes, Africa, Genetic biocontrol, Genomics, Population suppression, Sterile insect technique (SIT)
P. T. McDonald, W. Hausermann and N. Lorimer,
Am J Trop Med Hyg,
26:553-61.
1977.
The release of males heterozygous for one or two sex-linked translocations was effective in introducing a high level of sterility into a domestic population of Aedes aegypti at a Rabai village. The effect of the releases continued for several weeks after the release period. Male ...