Keywords: Aedes aegypti

Edit, undo: Temporary gene editing could help solve the mosquito problem

L. Dormehl,  digitaltrends,  2020.
But if SyFy original movies have taught us anything, it’s that genetically tweaking organisms and then releasing them can… well, not go quite according to plan.With that in mind, a new Texas A&M AgriLife Research project seeks to test out genetic modifications of mosquitos ...
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The Antiviral Small-Interfering RNA Pathway Induces Zika Virus Resistance in Transgenic Aedes aegypti

A. E. Williams, I. Sanchez-Vargas, W. R. Reid, J. Y. Lin, A. W. E. Franz and K. E. Olson,  Viruses,  12:18. 2020.
We used CRISPR/Cas9 to re-target a previously characterized locus (Chr2:321382225) and engineered mosquitoes expressing an inverted repeat (IR) dsRNA against the NS3/4A region of the ZIKV genome. Small RNA analysis revealed that the IR effector triggered the mosquito's siRNA ...
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Split drive killer-rescue provides a novel threshold-dependent gene drive

M. P. Edgington, T. Harvey-Samuel and L. Alphey,  Scientific Reports,  10:13. 2020.
We show that although end-joining repair mechanisms may cause the system to break down, under certain conditions, it should persist over time scales relevant for genetic control programs. The potential of such a system to provide localised population suppression via sex ratio ...
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Researchers convert female mosquitoes to nonbiting males with implications for mosquito control

Virginia Tech,  ScienceDaily,  2020.
Researchers convert female mosquitoes to nonbiting males with implications for mosquito control Virginia Tech researchers have proven that a single gene can convert female Aedes aegypti mosquitoes into fertile male mosquitoes and identified a gene needed for male mosquito ...
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GMO Mosquitoes to be launched in Florida

Administration,  Editorials 360,  2020.
In June 2020, the Florida Division of Agriculture and Shopper Providers gave the go-ahead to a plan to launch thousands and thousands of genetically engineered mosquitoes within the Florida Keys this summer time to battle mosquito-borne diseases.1 The plan follows the EPA’s ...
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Florida gives approval to the plan of releasing genetically modified mosquitoes.

V. Dalmia,  The Andoverleader,  2020.
Mosquitoes have always been a huge problem for Florida residents. They are even more problematic in the Florida Key Region. It has even a dedicated mosquito department that is assigned with the task of controlling over 40 species of mosquitoes. But as technology progresses, we ...
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Company Receives Permit To Release Swarm Of Genetically Modified Mosquitoes In Florida

I. Monzon,  International Business Times,  2020.
A federal agency has provided a biotech company with the proper permit to release a swarm of genetically altered mosquitoes in Florida as a way to curb the spread of diseases in the area. If the company receives the additional approvals, it might begin releasing the mosquitoes ...
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Mosquito-Borne Diseases Emergence/Resurgence and How to Effectively Control It Biologically

H. Dahmana and O. Mediannikov,  Pathogens,  9:26. 2020.
Deadly pathogens and parasites are transmitted by vectors and the mosquito is considered the most threatening vector in public health, transmitting these pathogens to humans and animals. We are currently witnessing the emergence/resurgence in new regions/populations of the most ...
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Synthetically engineered mosquitos could neutralize dengue virus infection

L. Woolfe,  Biotechniques,  2020.
Dengue virus infection can be severe and life threatening. New research has developed an improved approach to controlling this deadly infection.
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Mosquitoes genetically modified to combat dengue

Downtoearth,  Down To Earth,  2020.
For the first time mosquitoes have been engineered to fight all 4 known types of dengue
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Genetically Modified Mosquitos Neutralize Dengue Virus

N. P. Dyal,  Infectious Disease Advisor,  2020.
Researchers at the University of California San Diego have identified a target gene in mosquitos that renders the insects completely refractory to all 4 serotypes of the dengue virus and thus, incapable of transmitting the virus to humans, according to study results published in ...
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Genetically modified mosquitoes resist all dengue viruses, researchers find

B. Burton,  C|NET,  2020.
This new kind of mosquito can't spread any form of the deadly disease.
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Genetically engineered mosquitoes resist spreading any form of dengue

K. Servick,  Science,  2020.
Recover from dengue once, and you’re not necessarily free and clear. The mosquito-borne disease marked by fever, rash, and debilitating pain results from any of four genetically distinct versions of the dengue virus. Previously infected people who get hit with a second of these ...
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Genetically engineered mosquitoes halt Dengue spread

L. Thomas,  New Medical Life Sciences,  2020.
A new study published in the journal PLOS Pathogens in January 2020 reports the development of mosquitoes that have been genetically modified to resist infection by several types of the dengue virus. This is the first time ever that all types of the virus have been targeted by ...
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Researchers Genetically Modify First Batch Of Mosquitoes Resistant To All Four Types Of Dengue

M. Dapcevich,  IFL Science,  2020.
An international team of researchers have synthetically engineered a breed of mosquitos that are resistant to all four types of the dengue virus for the first time, a feat they say may someday suppress the disease and stop its transmission to humans.
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Genetically engineered mosquitoes are immune to all strains of dengue virus for first time

G. Weule,  ABC News Online,  2020.
Locked in a secure lab near Melbourne is the newest addition in the fight against dengue: genetically engineered mosquitoes that are resistant to all strains of the potentially deadly virus.
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Mosquitoes resistant to all types of dengue virus engineered

N. Lavars,  New Atlas,  2020.
Last year, scientists at Australia's Commonwealth Scientific and Industrial Research Organisation (CSIRO) made a big breakthrough, engineering mosquitoes that break the chain of Zika virus transmission. But they did so with multiple targets in mind, with the mosquito in question, ...
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Broad dengue neutralization in mosquitoes expressing an engineered antibody

A. Buchman, S. Gamez, M. Li, I. Antoshechkin, H.-H. Li, H.-W. Wang, C.-H. Chen, M. J. Klein, J.-B. Duchemin, J. E. Crowe, Jr., P. N. Paradkar and O. S. Akbari,  PLOS Pathogens,  16:e1008103. 2020.
Author summary With limited success of traditional vector control methods to curb dengue infections and more than half of the world’s population still at risk, there is a need for novel strategies to reduce its impact on public health. Recent advances in genetic technologies ...
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Development of a confinable gene drive system in the human disease vector Aedes aegypti

M. Li, T. Yang, N. P. Kandul, M. Bui, S. Gamez, R. Raban, J. Bennett, H. M. Sánchez C, G. C. Lanzaro, H. Schmidt, Y. Lee, J. M. Marshall and O. S. Akbari,  eLife,  9:e51701. 2020.
Aedes aegypti is the principal mosquito vector for many arboviruses that increasingly infect millions of people every year. With an escalating burden of infections and the relative failure of traditional control methods, the development of innovative control measures has become ...
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Antiviral effectors and gene drive strategies for mosquito population suppression or replacement to mitigate arbovirus transmission by Aedes aegypti

A. E. Williams, A. W. E. Franz, W. R. Reid and K. E. Olson,  Insects,  11:1-18. 2020.
The mosquito vector Aedes aegypti transmits arthropod-borne viruses (arboviruses) of medical importance, including Zika, dengue, and yellow fever viruses. Controlling mosquito populations remains the method of choice to prevent disease transmission. Novel mosquito control ...
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MGDrivE: A modular simulation framework for the spread of gene drives through spatially-explicit mosquito populations

Sánchez C, HMW, Sean L.; Bennett, Jared B.; Marshall, John M.,  Methods in Ecology and Evolution,  10:1-24. 2019.
Malaria, dengue, Zika, and other mosquito-borne diseases continue to pose a major global health burden through much of the world, despite the widespread distribution of insecticide-based tools and antimalarial drugs. The advent of CRISPR/Cas9-based gene editing and its ...
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Towards the genetic control of invasive species

Harvey-Samuel, TA, T.; Alphey, L.,  Biological Invasions,  19:1683-1703. 2017.
Invasive species remain one of the greatest threats to global biodiversity. Their control would be enhanced through the development of more effective and sustainable pest management strategies. Recently, a novel form of genetic pest management (GPM) has been developed in which ...
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Cheating evolution: engineering gene drives to manipulate the fate of wild populations

Champer, JB, A.; Akbari, O. S.,  Nature Reviews Genetics,  17:146-159. 2016.
Engineered gene drives - the process of stimulating the biased inheritance of specific genes - have the potential to enable the spread of desirable genes throughout wild populations or to suppress harmful species, and may be particularly useful for the control of vector-borne ...
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Regulatory experience and challenges for the release of GM insects

Beech, C,  Journal Fur Verbraucherschutz Und Lebensmittelsicherheit-Journal of Consumer Protection and Food Safety,  9:S71-S76. 2014.
Genetically modified (GM) insects are a potentially valuable new tool for the biological control of insect pests of humans, animals and plants. Considerable progress has been made recently in transfer of GM insects from the laboratory to release and evaluation in the environment. ...
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Requirements for effective malaria control with homing endonuclease genes

Deredec, AG, H. C. J.; Burt, A.,  Proceedings of the National Academy of Sciences of the United States of America,  108:e874-e880. 2011.
Malaria continues to impose a substantial burden on human health. We have previously proposed that biological approaches to control the mosquito vector of disease could be developed using homing endonuclease genes (HEGs), a class of selfish or parasitic gene that exists naturally ...
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