Keywords: Aedes aegypti

Combined sterile insect technique and incompatible insect technique: concept, study design, experience and lessons learned from a pilot suppression trial in Thailand

Kittayapong, P.,  AREA-WIDE INTEGRATED PEST MANAGEMENT: Development and Field Application,  2021.
Climate change, rapid global transport and land use change leading to urbanization and agricultural intensification have facilitated disease emergence in vulnerable regions like Southeast Asia, and also the global expansion of vectors and vector-borne diseases into other regions ...
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Novel Symbiotic Genome-Scale Model Reveals Wolbachia’s Arboviral Pathogen Blocking Mechanism in Aedes aegypti

N. E. Jiménez, Z. P. Gerdtzen, Á. Olivera-Nappa, J. C. Salgado and C. Conca,  mBio,  e0156321. 2021.
Arboviral diseases such as Zika and Dengue have been on the rise mainly due to climate change, and the development of new treatments and strategies to limit their spreading is needed. The use of Wolbachia as an approach for disease control has motivated new research related to ...
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wMel Wolbachia genome remains stable after 7 years in Australian Aedes aegypti field populations

K. R. Dainty, J. Hawkey, L. M. Judd, E. C. Pacidônio, J. M. Duyvestyn, D. S. Gonçalves, S. Y. Lin, T. B. O'Donnell, S. L. O'Neill, C. P. Simmons, K. E. Holt and H. A. Flores,  Microbial Genomics,  7. 2021.
Infection of wMel Wolbachia in Aedes aegypti imparts two signature features that enable its application for biocontrol of dengue. First, the susceptibility of mosquitoes to viruses such as dengue and Zika is reduced. Second, a reproductive manipulation is caused that enables wMel ...
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Why Genes That Make Mosquitoes Glow Can Help Reduce Vector-Borne Disease

E. Ricciuti,  Entomology Today,  2021.
Fireflies they are not, but glow they do. Not in the dark, to be sure, but mosquitoes genetically modified in the laboratory for an emerging approach to reducing the threat of vector-borne disease look like miniature neon signs when subjected to ultraviolet light. To produce ...
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Oxitec Advances Process to Bring Friendly™ Mosquito Technology to California to Help Government Agencies Protect Public Health

Oxitec,  Oxitec,  2021.
Following successful launch of its Friendly™ Aedes aegypti pilot program in the Florida Keys, Oxitec, the leading developer of biological solutions to control pests that transmit disease, destroy crops and harm livestock, has requested approval from the U.S. Environmental ...
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Unique effort underway to control deadly mosquitos in Florida Keys

K. Corso and L. Aguirre,  Local10.com,  2021.
According to the World Health Organization, more than 50% of the world’s population is under the threat of mosquito borne diseases. In South Florida, the Keys are a hot spot for infection and now the first place in the United States for a novel approach to eradicating these ...
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Manipulated Mosquitoes Cut Dengue by 77%

T. Hayes,  Healthcare Packaging,  2021.
Dengue, a mosquito-borne viral disease, wasn’t that common 50 years ago. In fact, only nine countries had severe outbreaks. But since then, it’s been on a steady incline to the point that there are now 400 million infections a year that contribute to 22,000 deaths. ...
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Dengue fever: Upstaged but not outmatched by COVID-19

C. E. Baclig,  INQUIRER.NET,  2021.
Science has made gains in the war on dengue and other diseases that mosquitoes carry, like malaria.One of these is the World Mosquito Program (WMP), a non-profit initiative that aims to protect the global community from mosquito-borne viral diseases, by deploying a natural ...
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Dengue Infections Can Be Sharply Reduced With Wolbachia Bacteria

J. Stone,  Medscape,  2021.
A modestly titled new study released in the New England Journal of Medicine belies the extraordinary 77% protective efficacy reported for preventing dengue infections with Wolbachia-infected Aedes aegypti mosquitoes. A cluster-randomized clinical trial, the AWED ("Applying ...
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Making mosquitoes to fight mosquitoes to prevent dengue

A. George,  Times of India,  2021.
In 2017, Delhi Chief Minister Arvind Kejriwal tweeted that the national capitl needed to be made mosquito-free. The same year, his Kerala counterpart, Pinaray Vijayan, called a three-day state-wide cleanliness drive as hospitals filled with genue patients.
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Dengue Fever Cut Down by 77% With Groundbreaking Bacteria-Armed Mosquitoes

M. Davis,  The Science Times,  2021.
Scientists found that dengue fever cases have decreased by 77% in a groundbreaking trial that took place in Yogyakarta City, Indonesia. They used Wolbachia-infected mosquitoes that reduced their ability to spread the dengue fever. The team at the World Mosquito Program said that ...
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Mosquito ‘bacteria hack’ nearly eliminates dengue fever and could save millions of lives

A. Wilkins,  METRO,  2021.
Mosquitoes infected with a ‘miraculous’ bacteria have been shown to reduce dengue fever cases by 77%, in a groundbreaking new study. Scientists released mosquitoes infected with ‘Wolbachia’ bacteria into the Indonesian city of Yogyakarta – but only in certain zones. In ...
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‘Miraculous’ mosquito hack cuts dengue by 77%

J. Gallagher,  BBC,  2021.
Dengue fever cases have been cut by 77% in a "groundbreaking" trial that manipulates the mosquitoes that spread it, say scientists. They used mosquitoes infected with "miraculous" bacteria that reduce the insect's ability to spread dengue. The trial took place in Yogyakarta city, ...
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Modified mosquitoes reduce dengue cases by 77% in Indonesia experiment

M. Fox,  CNN,  2021.
An experiment to infect mosquitoes with bacteria that stop them from transmitting viruses appears to have helped reduced the spread of deadly dengue virus in Indonesia, researchers reported Wednesday. The modified mosquitoes thrived for three years, and cases of dengue were ...
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Efficacy of Wolbachia-Infected Mosquito Deployments for the Control of Dengue

A. Utarini, C. Indriani, R. A. Ahmad, W. Tantowijoyo, E. Arguni, M. R. Ansari, E. Supriyati, D. S. Wardana, Y. Meitika, I. Ernesia, I. Nurhayati, E. Prabowo, B. Andari, B. R. Green, L. Hodgson, Z. Cutcher, E. Rancès, P. A. Ryan, S. L. O’Neill, S. M. Dufau,  New England Journal of Medicine,  384:2177-2186. 2021.
BACKGROUND Aedes aegypti mosquitoes infected with the wMel strain of Wolbachia pipientis are less susceptible than wild-type A. aegypti to dengue virus infection. METHODS We conducted a cluster-randomized trial involving releases of wMel-infected A. aegypti mosquitoes for the ...
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Mosquitoes armed with virus-fighting bacteria sharply curb dengue infections, hospitalizations

K. Servick,  Science,  2021.
A strategy for fighting dengue fever with bacteria-armed mosquitoes has passed its most rigorous test yet: a large, randomized, controlled trial. Researchers reported today dramatic reductions in rates of dengue infection and hospitalization in areas of an Indonesian city where ...
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Study demonstrates ‘exciting potential’ of Wolbachia-infected mosquitoes to control dengue

G. Gallagher,  Healio,  2021.
The release of Wolbachia-infected mosquitoes led to a 77% reduction in the incidence of symptomatic dengue in an Indonesian city, according to researchers, who said the same approach could be used to fight other mosquito-borne diseases. The study tested a strain of Wolbachia ...
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Genetic engineering may help control disease-carrying mosquitoes

Anonymous,  The Economist,  2021.
EVERY YEAR, hundreds of millions of people catch mosquito-borne diseases like malaria and dengue fever. Hundreds of thousands die. Drug treatments are imperfect. And, despite decades of effort, vaccines have, for many of these diseases, proved tricky to perfect. Better, then, to ...
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Genetically Modified Mosquitoes: What to Know

N. Pathak,  WebMD,  2021.
It sounds like something out of a movie: a biotech company releases genetically modified mosquitoes into the wild. But this is the real deal, a test that’s been done in a handful of countries around the world and that is underway in the U.S. Scientists hope these bugs can help ...
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Sterilizing skeeters using CRISPR/Cas9

H. Tasoff,  Phy Org,  2021.
Mosquitoes are one of humanity's greatest nemeses, estimated to spread infections to nearly 700 million people per year and cause more than one million deaths. UC Santa Barbara Distinguished Professor Craig Montell has made a breakthrough in one technique for controlling ...
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Edit, undo: Temporary gene editing could help solve the mosquito problem

L. Dormehl,  digitaltrends,  2020.
But if SyFy original movies have taught us anything, it’s that genetically tweaking organisms and then releasing them can… well, not go quite according to plan.With that in mind, a new Texas A&M AgriLife Research project seeks to test out genetic modifications of mosquitos ...
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The Antiviral Small-Interfering RNA Pathway Induces Zika Virus Resistance in Transgenic Aedes aegypti

A. E. Williams, I. Sanchez-Vargas, W. R. Reid, J. Y. Lin, A. W. E. Franz and K. E. Olson,  Viruses,  12:18. 2020.
We used CRISPR/Cas9 to re-target a previously characterized locus (Chr2:321382225) and engineered mosquitoes expressing an inverted repeat (IR) dsRNA against the NS3/4A region of the ZIKV genome. Small RNA analysis revealed that the IR effector triggered the mosquito's siRNA ...
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Split drive killer-rescue provides a novel threshold-dependent gene drive

M. P. Edgington, T. Harvey-Samuel and L. Alphey,  Scientific Reports,  10:13. 2020.
We show that although end-joining repair mechanisms may cause the system to break down, under certain conditions, it should persist over time scales relevant for genetic control programs. The potential of such a system to provide localised population suppression via sex ratio ...
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Researchers convert female mosquitoes to nonbiting males with implications for mosquito control

Virginia Tech,  ScienceDaily,  2020.
Researchers convert female mosquitoes to nonbiting males with implications for mosquito control Virginia Tech researchers have proven that a single gene can convert female Aedes aegypti mosquitoes into fertile male mosquitoes and identified a gene needed for male mosquito ...
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GMO Mosquitoes to be launched in Florida

Administration,  Editorials 360,  2020.
In June 2020, the Florida Division of Agriculture and Shopper Providers gave the go-ahead to a plan to launch thousands and thousands of genetically engineered mosquitoes within the Florida Keys this summer time to battle mosquito-borne diseases.1 The plan follows the EPA’s ...
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Florida gives approval to the plan of releasing genetically modified mosquitoes.

V. Dalmia,  The Andoverleader,  2020.
Mosquitoes have always been a huge problem for Florida residents. They are even more problematic in the Florida Key Region. It has even a dedicated mosquito department that is assigned with the task of controlling over 40 species of mosquitoes. But as technology progresses, we ...
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Company Receives Permit To Release Swarm Of Genetically Modified Mosquitoes In Florida

I. Monzon,  International Business Times,  2020.
A federal agency has provided a biotech company with the proper permit to release a swarm of genetically altered mosquitoes in Florida as a way to curb the spread of diseases in the area. If the company receives the additional approvals, it might begin releasing the mosquitoes ...
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Mosquito-Borne Diseases Emergence/Resurgence and How to Effectively Control It Biologically

H. Dahmana and O. Mediannikov,  Pathogens,  9:26. 2020.
Deadly pathogens and parasites are transmitted by vectors and the mosquito is considered the most threatening vector in public health, transmitting these pathogens to humans and animals. We are currently witnessing the emergence/resurgence in new regions/populations of the most ...
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Synthetically engineered mosquitos could neutralize dengue virus infection

L. Woolfe,  Biotechniques,  2020.
Dengue virus infection can be severe and life threatening. New research has developed an improved approach to controlling this deadly infection.
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Mosquitoes genetically modified to combat dengue

Downtoearth,  Down To Earth,  2020.
For the first time mosquitoes have been engineered to fight all 4 known types of dengue
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Genetically Modified Mosquitos Neutralize Dengue Virus

N. P. Dyal,  Infectious Disease Advisor,  2020.
Researchers at the University of California San Diego have identified a target gene in mosquitos that renders the insects completely refractory to all 4 serotypes of the dengue virus and thus, incapable of transmitting the virus to humans, according to study results published in ...
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Genetically modified mosquitoes resist all dengue viruses, researchers find

B. Burton,  C|NET,  2020.
This new kind of mosquito can't spread any form of the deadly disease.
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Genetically engineered mosquitoes resist spreading any form of dengue

K. Servick,  Science,  2020.
Recover from dengue once, and you’re not necessarily free and clear. The mosquito-borne disease marked by fever, rash, and debilitating pain results from any of four genetically distinct versions of the dengue virus. Previously infected people who get hit with a second of these ...
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Genetically engineered mosquitoes halt Dengue spread

L. Thomas,  New Medical Life Sciences,  2020.
A new study published in the journal PLOS Pathogens in January 2020 reports the development of mosquitoes that have been genetically modified to resist infection by several types of the dengue virus. This is the first time ever that all types of the virus have been targeted by ...
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Researchers Genetically Modify First Batch Of Mosquitoes Resistant To All Four Types Of Dengue

M. Dapcevich,  IFL Science,  2020.
An international team of researchers have synthetically engineered a breed of mosquitos that are resistant to all four types of the dengue virus for the first time, a feat they say may someday suppress the disease and stop its transmission to humans.
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Genetically engineered mosquitoes are immune to all strains of dengue virus for first time

G. Weule,  ABC News Online,  2020.
Locked in a secure lab near Melbourne is the newest addition in the fight against dengue: genetically engineered mosquitoes that are resistant to all strains of the potentially deadly virus.
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Mosquitoes resistant to all types of dengue virus engineered

N. Lavars,  New Atlas,  2020.
Last year, scientists at Australia's Commonwealth Scientific and Industrial Research Organisation (CSIRO) made a big breakthrough, engineering mosquitoes that break the chain of Zika virus transmission. But they did so with multiple targets in mind, with the mosquito in question, ...
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Broad dengue neutralization in mosquitoes expressing an engineered antibody

A. Buchman, S. Gamez, M. Li, I. Antoshechkin, H.-H. Li, H.-W. Wang, C.-H. Chen, M. J. Klein, J.-B. Duchemin, J. E. Crowe, Jr., P. N. Paradkar and O. S. Akbari,  PLOS Pathogens,  16:e1008103. 2020.
Author summary With limited success of traditional vector control methods to curb dengue infections and more than half of the world’s population still at risk, there is a need for novel strategies to reduce its impact on public health. Recent advances in genetic technologies ...
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Development of a confinable gene drive system in the human disease vector Aedes aegypti

M. Li, T. Yang, N. P. Kandul, M. Bui, S. Gamez, R. Raban, J. Bennett, H. M. Sánchez C, G. C. Lanzaro, H. Schmidt, Y. Lee, J. M. Marshall and O. S. Akbari,  eLife,  9:e51701. 2020.
Aedes aegypti is the principal mosquito vector for many arboviruses that increasingly infect millions of people every year. With an escalating burden of infections and the relative failure of traditional control methods, the development of innovative control measures has become ...
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Antiviral effectors and gene drive strategies for mosquito population suppression or replacement to mitigate arbovirus transmission by Aedes aegypti

A. E. Williams, A. W. E. Franz, W. R. Reid and K. E. Olson,  Insects,  11:1-18. 2020.
The mosquito vector Aedes aegypti transmits arthropod-borne viruses (arboviruses) of medical importance, including Zika, dengue, and yellow fever viruses. Controlling mosquito populations remains the method of choice to prevent disease transmission. Novel mosquito control ...
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Malaysia Wolbachia trials: Battling dengue and other mosquito-borne viruses

,  2019.

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MGDrivE: A modular simulation framework for the spread of gene drives through spatially-explicit mosquito populations

Sánchez C, HMW, Sean L.; Bennett, Jared B.; Marshall, John M.,  Methods in Ecology and Evolution,  10:1-24. 2019.
Malaria, dengue, Zika, and other mosquito-borne diseases continue to pose a major global health burden through much of the world, despite the widespread distribution of insecticide-based tools and antimalarial drugs. The advent of CRISPR/Cas9-based gene editing and its ...
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Towards the genetic control of invasive species

Harvey-Samuel, TA, T.; Alphey, L.,  Biological Invasions,  19:1683-1703. 2017.
Invasive species remain one of the greatest threats to global biodiversity. Their control would be enhanced through the development of more effective and sustainable pest management strategies. Recently, a novel form of genetic pest management (GPM) has been developed in which ...
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Cheating evolution: engineering gene drives to manipulate the fate of wild populations

Champer, JB, A.; Akbari, O. S.,  Nature Reviews Genetics,  17:146-159. 2016.
Engineered gene drives - the process of stimulating the biased inheritance of specific genes - have the potential to enable the spread of desirable genes throughout wild populations or to suppress harmful species, and may be particularly useful for the control of vector-borne ...
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Regulatory experience and challenges for the release of GM insects

Beech, C,  Journal Fur Verbraucherschutz Und Lebensmittelsicherheit-Journal of Consumer Protection and Food Safety,  9:S71-S76. 2014.
Genetically modified (GM) insects are a potentially valuable new tool for the biological control of insect pests of humans, animals and plants. Considerable progress has been made recently in transfer of GM insects from the laboratory to release and evaluation in the environment. ...
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Requirements for effective malaria control with homing endonuclease genes

Deredec, AG, H. C. J.; Burt, A.,  Proceedings of the National Academy of Sciences of the United States of America,  108:e874-e880. 2011.
Malaria continues to impose a substantial burden on human health. We have previously proposed that biological approaches to control the mosquito vector of disease could be developed using homing endonuclease genes (HEGs), a class of selfish or parasitic gene that exists naturally ...
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