Keywords: antidote

Design and analysis of CRISPR-based underdominance toxin-antidote gene drives

J. Champer, S. E. Champer, I. K. Kim, A. G. Clark and P. W. Messer,  Evolutionary Applications,  18. 2020.
We model drives which target essential genes that are either haplosufficient or haplolethal, using nuclease promoters with expression restricted to the germline, promoters that additionally result in cleavage activity in the early embryo from maternal deposition, and promoters ...
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The Biochemistry of Cytoplasmic Incompatibility Caused by Endosymbiotic Bacteria

H. Chen, M. Zhang and M. Hochstrasser,  Genes,  11. 2020.
Many species of arthropods carry maternally inherited bacterial endosymbionts that can influence host sexual reproduction to benefit the bacterium. The most well-known of such reproductive parasites is Wolbachia pipientis. Wolbachia are obligate intracellular ...
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