Keywords: cancer therapy

Programmed evolution: Using asexual gene drives to sculpt tumor populations and combat genetic diversity

Justin Pritchard, Scott Leighow, Joshua Reynolds et al.,  Research Square,  2024.
Resistance evolution is responsible for the failure of most targeted anticancer therapies. Tumor heterogeneity is so profound that pre-existing resistance is thought to be guaranteed at the time that advanced disease is detected. The practice of waiting for treatment failure and ...
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