Keywords: Cas 9 nickase
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A nickase Cas9 gene-drive system promotes super-Mendelian inheritance in DrosophilaV. L. Del Amo, S. S. Juste and V. M. Gantz, Cell Rep, 39:110843. 2022.
CRISPR-based gene-drives have been proposed for managing insect populations, including disease-transmitting mosquitoes, due to their ability to bias their inheritance toward super-Mendelian rates (>50%). Current technologies use a Cas9 that introduces DNA double-strand breaks ... |
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CRISPR gene-drive systems based on Cas9 nickases promote super-Mendelian inheritance in DrosophilaV. Lopez del Amo, S. Sanz Juste and V. M. Gantz, bioRxiv, 2021.12.01.470847. 2021.
CRISPR-based gene drive systems can be used to modify entire wild populations due to their ability to bias their own inheritance towards super-Mendelian rates (>100%). Current gene drives contain a Cas9 and a gRNA gene inserted at the location targeted by the gRNA. These ... |
