Keywords: centromere drive

Meiotic drive in house mice: mechanisms, consequences, and insights for human biology

U. P. Arora and B. L. Dumont,  Chromosome Research,  2022.
Meiotic drive occurs when one allele at a heterozygous site cheats its way into a disproportionate share of functional gametes, violating Mendel's law of equal segregation. This genetic conflict typically imposes a fitness cost to individuals, often by disrupting the process of ...
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Centromere drive: model systems and experimental progress

D. Dudka and M. A. Lampson,  Chromosome Research,  2022.
Centromeres connect chromosomes and spindle microtubules to ensure faithful chromosome segregation. Paradoxically, despite this conserved function, centromeric DNA evolves rapidly and centromeric proteins show signatures of positive selection. The centromere drive hypothesis ...
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Evolution of eukaryotic centromeres by drive and suppression of selfish genetic elements

T. Kumon and M. A. Lampson,  Seminars in Cell and Developmental Biology,  2022.
Despite the universal requirement for faithful chromosome segregation, eukaryotic centromeres are rapidly evolving. It is hypothesized that rapid centromere evolution represents an evolutionary arms race between selfish genetic elements that drive, or propagate at the expense of ...
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Centromere function in asymmetric cell division in Drosophila female and male germline stem cells

A. M. Kochendoerfer, F. Modafferi and E. M. Dunleavy,  Open Biology,  11:210107. 2021.
The centromere is the constricted chromosomal region required for the correct separation of the genetic material at cell division. The kinetochore protein complex assembles at the centromere and captures microtubules emanating from the centrosome to orchestrate chromosome ...
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Flavors of Non-Random Meiotic Segregation of Autosomes and Sex Chromosomes

F. Pajpach, T. Wu, L. Shearwin-Whyatt, K. Jones and F. Grützner,  Genes,  12. 2021.
Segregation of chromosomes is a multistep process occurring both at mitosis and meiosis to ensure that daughter cells receive a complete set of genetic information. Critical components in the chromosome segregation include centromeres, kinetochores, components of sister chromatid ...
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Parallel pathways for recruiting effector proteins determine centromere drive and suppression

T. Kumon, J. Ma, R. B. Akins, D. Stefanik, C. E. Nordgren, J. Kim, M. T. Levine and M. A. Lampson,  Cell,  2021.
Selfish centromere DNA sequences bias their transmission to the egg in female meiosis. Evolutionary theory suggests that centromere proteins evolve to suppress costs of this "centromere drive." In hybrid mouse models with genetically different maternal and paternal centromeres, ...
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Selfish chromosomal drive shapes recent centromeric histone evolution in monkeyflowers

F. R. Finseth, T. C. Nelson and L. Fishman,  PLOS Genetics,  17:e1009418. 2021.
Centromeres must mediate faithful chromosomal transmission during cell division and sexual reproduction, but both the DNA and protein components of centromeres diverge rapidly across species. The selfish centromere model argues that this paradoxical diversity results from a ...
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Holocentric Chromosomes Probably Do Not Prevent Centromere Drive in Cyperaceae

M. Kratka, J. Smerda, K. Lojdova, P. Bures and F. Zedek,  Frontiers in Plant Science,  12:9. 2021.
In response to these selfish centromeres, the histone protein CenH3, which recruits kinetochore components, adaptively evolves to restore chromosomal parity and counter the detrimental effects of centromere drive. Holocentric chromosomes, whose kinetochores are assembled along ...
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A test for meiotic drive in hybrids between Australian and Timor zebra finches

U. Knief, W. Forstmeier, Y. Pei, J. Wolf and B. Kempenaers,  Ecology and Evolution,  2020.
We did not find evidence for meiotic driver loci on specific chromosomes. However, we observed a weak overall transmission bias toward Timor alleles at centromeres in females (transmission probability of Australian alleles of 47%, nominal p = 6 ? 10?5). While this is in line ...
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