Keywords: CidA

Convergent Aedes and Drosophila CidB interactomes suggest cytoplasmic incompatibility targets are conserved

S. O. Oladipupo, J. D. Carroll and J. F. Beckmann,  Insect Biochem Mol Biol,  103931. 2023.
Wolbachia-mediated cytoplasmic incompatibility (CI) is a conditional embryonic lethality induced when Wolbachia-modified sperm fertilizes an uninfected egg. The Wolbachia proteins, CidA and CidB control CI. CidA is a rescue factor that reverses lethality. CidA binds to CidB. CidB ...
Keywords: , , , , , ,

Functional analysis of Wolbachia Cid effectors unravels cooperative interactions to target host chromatin during replication

K. Terretaz, B. Horard, M. Weill, B. Loppin and F. Landmann,  PLOS Pathogens,  19:e1011211. 2023.
Wolbachia are common bacteria among terrestrial arthropods. These endosymbionts transmitted through the female germline manipulate their host reproduction through several mechanisms whose most prevalent form called Cytoplasmic Incompatibility -CI- is a conditional sterility ...
Keywords: , , , , , ,

Cytoplasmic incompatibility: A Wolbachia toxin–antidote mechanism comes into view

M. Hochstrasser,  Current Biology,  32:R287-R289. 2022.
The Wolbachia cidA and cidB genes promote bacterial endosymbiont inheritance through the host female germline. CidB is now shown to load into maturing sperm nuclei. Following fertilization, it disrupts paternal chromosome condensation, triggering embryonic arrest if not countered ...
Keywords: , , , , , ,