Keywords: CifB

Harnessing Wolbachia cytoplasmic incompatibility alleles for confined gene drive: a modeling study

J. Li and J. Champer,  bioRxiv,  2022.08.09.503337. 2022.
By using both mathematical and simulation models, we found that a drive containing CifA and CifB together create a confined drive with a moderate to high introduction threshold. When introduced separately, they act as a self-limiting drive. We observed that the performance of ...
Keywords: , , , , ,

cifB-transcript levels largely explain cytoplasmic incompatibility variation across divergent Wolbachia

J. D. Shropshire, E. Hamant, W. R. Conner and B. S. Cooper,  PNAS Nexus,  2022.
Divergent hosts often associate with intracellular microbes that influence their fitness. Maternally transmitted Wolbachia bacteria are the most common of these endosymbionts due largely to cytoplasmic incompatibility (CI) that kills uninfected embryos fertilized by ...
Keywords: , , , , ,

Perplexing dynamics of Wolbachia proteins for cytoplasmic incompatibility

T. Harumoto and T. Fukatsu,  PLOS Biology,  20:e3001644. 2022.
The mechanism of symbiont-induced cytoplasmic incompatibility has been a long-lasting mystery. This Primer explores a new study on Wolbachia’s Cif proteins in PLOS Biology that provides supportive evidence for the “Host-Modification Model,” although the alternative ...
Keywords: , , , , ,

The Cif proteins from Wolbachia prophage WO modify sperm genome integrity to establish cytoplasmic incompatibility

R. Kaur, B. A. Leigh, I. T. Ritchie and S. R. Bordenstein,  PLOS Biology,  20:e3001584. 2022.
In Drosophila melanogaster, germline expression of the Wolbachia proteins CifA and CifB causes cytoplasmic incompatibility, but how this impairs male reproduction remains unclear. This study shows how Cif proteins encoded by the endosymbiont prophage invade the fly’s gametic ...
Keywords: , , , , ,