
Keywords: cleave
![]() |
A home and rescue gene drive forces its inheritance stably persisting in populationsN. P. Kandul, J. Liu, J. B. Bennett, J. M. Marshall and O. Akbari, bioRxiv, 2020.08.21.261610. 2020.![]() We demonstrate that HomeR can achieve nearly ~100% transmission enabling it to persist at genotypic fixation in several multi-generational population cage experiments, underscoring its long term stability. Keywords: cleave, gene drive genetics, gene drive mechanism, gene drvie synthetic, rescue, resistance, self limiting |
![]() |
2-Locus Cleave and Rescue; selfish elements harness a recombination rate-dependent generational clock for self limiting gene driveG. Oberhofer, T. Ivy and B. A. Hay, bioRxiv, 2020.![]() Self-limiting gene drive allows control over the spread and fate of linked traits. Cleave and Rescue (ClvR) elements create self-sustaining drive and comprise a DNA sequence-modifying enzyme (Cas9-gRNAs, Cleaver) that disrupts an essential gene, and a tightly linked, uncleavable ... Keywords: cleave, gene drive genetics, gene drive mechanism, gene drvie synthetic, rescue, resistance, self limiting |

Contact
David O’Brochta
Foundation for the
National Institutes of Health
geneconvenevi@fnih.org
RSS