Keywords: cleave
A home and rescue gene drive forces its inheritance stably persisting in populationsN. P. Kandul, J. Liu, J. B. Bennett, J. M. Marshall and O. Akbari, bioRxiv, 2020.08.21.261610. 2020.We demonstrate that HomeR can achieve nearly ~100% transmission enabling it to persist at genotypic fixation in several multi-generational population cage experiments, underscoring its long term stability. Keywords: cleave, gene drive genetics, gene drive mechanism, gene drvie synthetic, rescue, resistance, self limiting |
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2-Locus Cleave and Rescue; selfish elements harness a recombination rate-dependent generational clock for self limiting gene driveG. Oberhofer, T. Ivy and B. A. Hay, bioRxiv, 2020.Self-limiting gene drive allows control over the spread and fate of linked traits. Cleave and Rescue (ClvR) elements create self-sustaining drive and comprise a DNA sequence-modifying enzyme (Cas9-gRNAs, Cleaver) that disrupts an essential gene, and a tightly linked, uncleavable ... Keywords: cleave, gene drive genetics, gene drive mechanism, gene drvie synthetic, rescue, resistance, self limiting |
Contact
David O’Brochta
Foundation for the
National Institutes of Health
geneconvenevi@fnih.org
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