Keywords: complex

Controlling invasive rodents via synthetic gene drive and the role of polyandry

Manser, AC, S. J.; Sutter, A.; Blondel, D. V.; Serr, M.; Godwin, J.; Price, T. A. R.,  Proceedings of the Royal Society B-Biological Sciences,  286:9. 2019.
House mice are a major ecosystem pest, particularly threatening island ecosystems as a non-native invasive species. Rapid advances in synthetic biology offer new avenues to control pest species for biodiversity conservation. Recently, a synthetic sperm-killing gene drive ...
Keywords: , , , , , , ,

A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila

Chen, CHH, H. X.; Ward, C. M.; Su, J. T.; Schaeffer, L. V.; Guo, M.; Hay, B. A.,  Science,  316:597-600. 2007.
One proposed strategy for controlling the transmission of insect-borne pathogens uses a drive mechanism to ensure the rapid spread of transgenes conferring disease refractoriness throughout wild populations. Here, we report the creation of maternal-effect selfish genetic elements ...
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Competition at the Mouse t Complex: Rare Alleles Are Inherently Favored

van Boven, MW, Franz J.,  Theoretical Population Biology,  60:343-358. 2001.
We investigate the competition between alleles at a segregation distorter locus. The focus is on the invasion prospects of rare mutant distorter alleles in a population in which a wildtype and a resident distorter allele are present. The parameters are chosen to reflect the ...
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