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Keywords: Contained

Gene drives do not always increase in frequency: from genetic models to risk assessment

de Jong, TJ, Journal Fur Verbraucherschutz Und Lebensmittelsicherheit-Journal of Consumer Protection and Food Safety, 12:299-307. 2017.

Homing genes encode endonucleases that make a double stranded break in the DNA, destroying a target site on the homologous chromosome. When the cell repairs the break the homing allele is copied, converting a heterozygote into a homozygote. This results in gene drive (GD), an ...
Keywords: Contained, CRISPR-Cas9, Environmental risk analysis, Evolution, Food Science & Technology, Gene drive, gene drive evolution, gene drive genetics, gene drive models, Homing, homing endonuclease genes, meiotic drive, mutagenic chain-reaction, natural-populations, risk, synthetic homing drive, use, vector