Small-Molecule Control of Super-Mendelian Inheritance in Gene DrivesV. López Del Amo, B. S. Leger, K. J. Cox, S. Gill, A. L. Bishop, G. D. Scanlon, J. A. Walker, V. M. Gantz and A. Choudhary, Cell Reports, 31:107841. 2020.
Summary Synthetic CRISPR-based gene-drive systems have tremendous potential in public health and agriculture, such as for fighting vector-borne diseases or suppressing crop pest populations. These elements can rapidly spread in a population by breaching the inheritance limit of ...
Keywords: Cas 9, CopyCat, CRISPR, destabilized domain, DHFR, drug control, Gene drive, gene drvie synthetic, Homing, small molecule, split gene drive, super-Mendelian, synthetic homing drive
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