Keywords: dominant lethal

Engineered action at a distance: Blood-meal-inducible paralysis in Aedes aegypti

R. E. Haghighat-Khah, T. Harvey-Samuel, S. Basu, O. StJohn, S. Scaife, S. Verkuijl, E. Lovett and L. Alphey,  PLOS Neglected Tropical Diseases,  13:e0007579. 2019.
Here we demonstrate that it is possible to engineer ‘non-cell autonomous’ effectors–that is where the effect (e.g. the action of a toxic protein) can act on cells distant from the tissues in which they are originally expressed. To achieve this we utilised the endogenous ...
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