Keywords: dominant lethal

Population suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in Drosophila

C. Weizhe, G. Jialiang, L. Yiran and C. Jackson,  bioRxiv,  2023.07.17.549342. 2023.
Gene drive alleles, which bias their own inheritance and increase in frequency, show great promise for blocking disease transmission or directly suppressing pest populations. The most common engineered drive system is the CRISPR homing drive, which converts wild-type alleles to ...
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Engineered action at a distance: Blood-meal-inducible paralysis in Aedes aegypti

R. E. Haghighat-Khah, T. Harvey-Samuel, S. Basu, O. StJohn, S. Scaife, S. Verkuijl, E. Lovett and L. Alphey,  PLOS Neglected Tropical Diseases,  13:e0007579. 2019.
Here we demonstrate that it is possible to engineer ‘non-cell autonomous’ effectors–that is where the effect (e.g. the action of a toxic protein) can act on cells distant from the tissues in which they are originally expressed. To achieve this we utilised the endogenous ...
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