Keywords: drive resistance

Gene Drive Basics – Characteristics and Properties

GeneConvene Global Collaborative,  GeneConvene Global Collaborative,  2020.
This short video covers the concept of 'drive strength', 'drive thresholds', 'spreading', 'resistance' and describes two strategies by which transmission advantages can be achieved.  The video is intended to provide additional insights into the technology to enable and encourage ...
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Population-level multiplexing: A promising strategy to manage the evolution of resistance against gene drives targeting a neutral locus

M. P. Edgington, T. Harvey-Samuel and L. Alphey,  Evolutionary Applications,  10. 2020.
CRISPR-based gene drives bias inheritance in their favour by inducing double-stranded breaks (DSBs) at wild-type homologous loci and using the drive transgene as a repair template-converting drive heterozygotes into homozygotes. Recent studies have shown that alternate ...
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Multiple loci of small effect confer wide variability in efficiency and resistance rate of CRISPR gene drive

J. Champer, Z. Wen, A. Luthra, R. Reeves, J. Chung, C. Liu, Y. L. Lee, J. Liu, E. Yang, P. W. Messer and A. G. Clark,  bioRxiv,  447615. 2018.
Gene drives could allow for control of vector-borne diseases by directly suppressing vector populations or spreading genetic payloads designed to reduce pathogen transmission. CRISPR homing gene drives work by cleaving wild-type alleles, which are then converted to drive alleles ...
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