Keywords: engagement
|
Off Target: Gene Drives and the Balance of LifeSave Our Seeds, 2023.
This is a compilation of conversations with experts about gene drive technologies and the science/social questions it raises. |
|
The attitudes of young adults towards mammalian predator control and Predator Free 2050 in Aotearoa New ZealandL. Dickie and F. Medvecky, Australasian Journal of Environmental Management, 2023.
Predator Free 2050 (PF2050) is an ambitious goal that aims to remove three types of invasive mammals from New Zealand by 2050. It will require a significant amount of funding, research, and support. Young adults will have an important role to play for this programme to be ... |
|
Gene DrivesD. M. Berube, Pandemics and Resilience, 2023.
A “gene drive” is a version of gene editing—a newer, more precise way to change a DNA (or RNA) sequence; in this case, combining a guide RNA with an enzyme that can make a gene drive takes this to another level, making sure that a new or altered genetic sequence has a ... |
|
Gene Drives as Interventions into Nature: the Coproduction of Ontology and Morality in the Gene Drive DebateK. Boersma, B. Bovenkerk and D. Ludwig, NanoEthics, 17:4. 2023.
Gene drives are potentially ontologically and morally disruptive technologies. The potential to shape evolutionary processes and to eradicate (e.g. malaria-transmitting or invasive) populations raises ontological questions about evolution, nature, and wilderness. The ... |
|
Engagement on risk assessment for gene drive mosquitoes by EFSA and Target MalariaS. Hartley, A. Kokotovich, Y. Devos and J. Mumford, Environmental Science and Policy, 142:183-193. 2023.
As engineered gene drive technologies continue to advance, many actors are actively considering how environmental risk assessments (RAs) for gene drive organisms should be conducted, and how stakeholder engagement opportunities should be provided. There is, however, a lack of ... |
|
Moving beyond narrow definitions of gene drive: Diverse perspectives and frames enable substantive dialogue among science and humanities teachers in the United States and United KingdomS. Hartley, A. Stelmach, J. A. Delborne and S. K. Barnhill-Dilling, Public Understanding of Science, 2023.
Gene drive is an emerging biotechnology with applications in global health, conservation and agriculture. Scientists are preparing for field trials, triggering debate about when and how to release gene-drive organisms. These decisions depend on public understandings of gene ... |
|
Trust in science and scientists: Effects of social attitudes and motivations on views regarding climate change, vaccines and gene drive technologyH. G. W. Dixson, A. F. Komugabe-Dixson, F. Medvecky, J. Balanovic, H. Thygesen and E. A. MacDonald, Journal of Trust Research, 2023.
Trust in science and scientists (TSS) is an increasingly important topic with respect to how science is applied within society. However, its role regarding specific issues may vary depending upon other psychosocial factors. In this study, we investigated how trust interacts with ... |
|
Exploring the value of a global gene drive project registryR. I. Taitingfong, C. Triplett, V. N. Vásquez, R. M. Rajagopalan, R. Raban, A. Roberts, G. Terradas, B. Baumgartner, C. Emerson, F. Gould, F. Okumu, C. E. Schairer, H. C. Bossin, L. Buchman, K. J. Campbell, A. Clark, J. Delborne, K. Esvelt, J. Fisher, R., Nature Biotechnology, 2022.
Recent calls to establish a global project registry before releasing any gene-drive-modified organisms (GDOs) have suggested a registry could be valuable to coordinate research, collect data to monitor and evaluate potential ecological impacts, and facilitate transparent ... |
|
Influence of public hesitancy and receptivity on reactive behaviours towards releases of male Wolbachia-Aedes mosquitoes for dengue controlM. O. Lwin, Z. Ong, C. Panchapakesan, A. Sheldenkar, L. T. Soh, I. Chen, X. Li, W. Niah, K. Vasquez, S. Sim and L.-C. Ng, PLOS Neglected Tropical Diseases, 16:e0010910. 2022.
Singapore, a highly urbanized Asian tropical country that experiences periodic dengue outbreaks, is piloting field releases of male Wolbachia-carrying Aedes aegyptimosquitoes with the aim of suppressing urban populations of the primary dengue vector Aedes aegypti. This study ... |
|
Why we need to talk about ‘gene-drive’ grey squirrelsL. Clarke, DevonLive, 2022.
Would the best way of controlling the UK’s rampant grey squirrel population be to spread genetic changes throughout the species? A new research film, to be shown next month at Exeter Phoenix, sees scientists, conservation and wildlife experts debate the use of emergent ... |
|
Hurdles in responsive community engagement for the development of environmental biotechnologiesA. M. Normandin, L. M. Fitzgerald, J. Yip and S. W. Evans, Synthetic Biology, 7:ysac022. 2022.
Recent calls for engaging communities in biotechnology development do not draw enough attention to the hurdles that must be overcome for engagement strategies to effectively feed back into research design and conduct. These hurdles call into question many standard ways of ... |
|
Public perspectives towards using gene drive for invasive species management in AustraliaA. Mankad, E. V. Hobman and L. Carter, CSIRO, 2022.
Many pest animal species live and reproduce in high numbers across Australia. This includes animal species, such as cane toads, feral cats, foxes, rodents, wild pigs, wild rabbits. These species significantly damage Australia’s agricultural industries, natural landscapes, and ... |
|
Public deliberation and the regulation of gene drive in the USAW. F. West, L. W. Buchman and R. F. Medina, Science and Public Policy, scac032. 2022.
Gene drive is a new form of biotechnology designed to bias the inheritance of selected traits in animal or plant species that reproduce sexually and have relatively short reproductive cycles. Unlike traditional breeding techniques and other forms of biotechnology, gene drive is ... |
|
Who decides whether to use gene drives against malaria-carrying mosquitoes?T. H. Saey, ScienceNews, 2022.
The gene drive interferes with the insects’ ability to reproduce. It wiped out captive populations of mosquitoes in eight to 12 generations (SN: 10/27/18, p. 6) in a small lab study. In 2021, the technology worked in the large cages in Terni, Italy, too. Within as little as ... |
|
Exploring value changeT. E. de Wildt and V. J. Schweizer, Prometheus, 38. 2022.
This article aims to explore the use of cross-impact balances (CIB) to identify scenarios of value change. The possibility of value change has received little attention in the literature on value-sensitive design (VSD). Examples of value change include the emergence of new values ... |
|
Recommendations for environmental risk assessment of gene drive applications for malaria vector controlJ. B. Connolly, J. D. Mumford, D. C. M. Glandorf, S. Hartley, O. T. Lewis, S. W. Evans, G. Turner, C. Beech, N. Sykes, M. B. Coulibaly, J. Romeis, J. L. Teem, W. Tonui, B. Lovett, A. Mankad, A. Mnzava, S. Fuchs, T. D. Hackett, W. G. Landis, J. M. Marshall, Malar J, 21:152. 2022.
Building on an exercise that identified potential harms from simulated investigational releases of a population suppression gene drive for malaria vector control, a series of online workshops identified nine recommendations to advance future environmental risk assessment of gene ... |
|
Prescribing engagement in environmental risk assessment for gene drive technologyS. Hartley, A. Kokotovich and C. McCalman, Regulation and Governance, 2022.
Abstract Gene drive technology is a nascent biotechnology with the potential to purposefully alter or eliminate a species. There have been broad calls for engagement to inform gene drive governance. Over the past seven years, the gene drive community has been developing risk ... |
|
Opening up, closing down, or leaving ajar? How applications are used in engaging with publics about gene driveA. W. Russell, A. Stelmach, S. Hartley, L. Carter and S. Raman, Journal of Responsible Innovation, 2022.
Public engagement and responsible innovation are strongly emphasised in gene drive research, together with the goal of addressing societal challenges, notably, malaria and environmental conservation. We aim to explore whether public engagement is used to ‘open up' or ‘close ... |
|
The power of gene editingThe Economist, The Economist, 2022.
Technologies such as genetic modification and ‘CRISPR’ will cure hereditary diseases, produce disease-resistant crops and enable the breeding of malaria-free mosquitos. But advances bring ethical and practical dilemmas. Genetically modified food is banned in the EU, and ... |
|
California Residents’ Perceptions of Gene Drive Systems to Control Mosquito-Borne DiseaseC. E. Schairer, C. Triplett, O. S. Akbari and C. S. Bloss, Frontiers in Bioengineering and Biotechnology, 10. 2022.
Scientists developing gene drive mosquitoes for vector control must understand how residents of affected areas regard both the problem of mosquito-borne disease and the potential solutions offered by gene drive. This study represents an experiment in public engagement at an early ... |
|
|
Articulating ethical principles guiding Target Malaria’s engagement strategyA. J. Roberts and D. Thizy, Malaria Journal, 21:35. 2022.
Progress in gene drive research has engendered a lively discussion about community engagement and the ethical standards the work hinges on. While there is broad agreement regarding ethical principles and established best practices for conducting clinical public health research, ... |
|
Conditions for Investment in Genetic Biocontrol of Pest Vertebrates in AustraliaL. Carter, A. Mankad, S. Campbell, W. Ruscoe, K. P. Oh, P. R. Brown, M. Byrne, M. Tizard and T. Strive, Frontiers in Agronomy, 3. 2022.
Managing pest vertebrate species in Australia is a significant challenge for government, industry, research sectors and land-managers. Innovative tools such as genetic biocontrol offers decision-makers a potentially effective means of reducing the impact of pest species ... |
|
Gene Drives in the U.K., U.S., and Australian Press (2015–2019): How a New Focus on Responsibility Is Shaping Science CommunicationA. Stelmach, B. Nerlich and S. Hartley, Science Communication, 10755470211072245. 2022.
Gene drive is a controversial biotechnology for pest control. Despite a commitment from gene drive researchers to responsibility and the key role of the media in debates about science and technology, little research has been conducted on media reporting of gene drive. We employ ... |
|
Ethical Considerations for Gene Drive: Challenges of Balancing Inclusion, Power and PerspectivesA. Kormos, G. C. Lanzaro, E. Bier, V. Santos, L. Nazare, J. Pinto, A. A. dos Santos and A. James, Frontiers in Bioengineering and Biotechnology, 2022.
Progress in gene-drive research has stimulated discussion and debate on ethical issues including community engagement and consent, policy and governance, and decision-making involved in development and deployment. Many organizations, academic institutions, foundations, and ... |
|
Gene drives and metaphorsB. Nerlich, Making Science Public, 2022.
I have been writing about developments in the biosciences for twenty years. In that time, I have covered a wide variety of topics, such as cloning, genomics, the human genome project, the microbiome project, faecal microbial transplants, synthetic biology, epigenetics, genome ... |
|
Gene drive communication: exploring experts’ lived experience of metaphor useB. Nerlich and A. Stelmach, New Genetics and Society, 2022.
Metaphors have been crucial in making genetics and genomics public, fromthe code and the book of life to genetic scissors and gene surgery. A newfield is emerging called“gene drive”–a range of controversial technologiesthat can potentially be used for the eradication or ... |
|
Information Sharing in Senegal on the Gene Drive Technology as a potential Complementary Tool for Malaria Vector ControlAUDA-NEPAD, AUDA-NEPAD, 2022.
AUDA-NEPAD in partnership with the National Biosafety Authority (Autorité Nationale de Biosécurité (ANB) in Senegal organized an Information sharing meeting on the gene drive technology as a complementary tool for malaria vector control, from 22-23 December 2021, in Somone, ... |
|
Facilitating the Conversation: Gene Drive ClassificationJ. Overcash and A. Golnar, Health Security, 2021.
Gene drives are an emerging technology with tremendous potential to impact public health, agriculture, and conservation. While gene drives can be described simply as selfish genetic elements (natural or engineered) that are inherited at non-Mendelian rates, upon closer ... |
|
Determinants of stakeholders’ attitudes and intentions toward supporting the use of Wolbachia-infected Aedes mosquitoes for dengue controlA. F. Arham, L. Amin, M. A. C. Mustapa, Z. Mahadi, M. Yaacob and M. Ibrahim, BMC Public Health, 21:2314. 2021.
BACKGROUND: A recent approach in controlling dengue is by using the Wolbachia-infected Aedes mosquito (WiAM). The approach has been reported to be more effective than traditional methods, such as fogging. Therefore, it is imperative to assess the factors predicting its acceptance ... |
|
Integrated Management of Malaria Vectors in AfricaR. Mbabazi, K. Maredia, B. B. El-Sayed, A. K. Babumba, M. Savadogo and O. Akinbo, Genetically Modified and other Innovative Vector Control Technologies, 2021.
Malaria disease is a major public health burden in Africa. The control of malaria vectors is a critical component for prevention, management, and eradication of malaria disease. This chapter presents information on the current status of malaria vector control in Africa with ... |
|
|
Arthropods of Medical Importance: Need for Genetic and Other Innovative Vector Control Technologies, with Emphasis on Eco-biosocial and Environmental Considerations.B. K. Tyagi, Genetically Modified and other Innovative Vector Control Technologies, 2021.
Among the world’s known vector groups, viz. arthropods, snails and rodents, the most important vectors originate from arthropods, the jointed legs. Arthropods are doubtlessly regarded as the most dominant creatures on the Earth due largely to their remarkable structural and ... |
|
Genetically Modified and other Innovative Vector Control TechnologiesB. K. Tyagi, SpringerLink, 2021.
This book comprehensively covers the latest development in developing and deploying the genetically modified vectors, particularly Anopheles and Aedes mosquitoes responsible for transmitting malaria parasites and dengue viruses, the most deadly and/or debilitating among all the ... |
|
Malaria vector control tools in emergency settings: What do experts think? Results from a DELPHI surveyC. Boete, S. Burza, E. Lasry, S. Moriana and W. Robertson, Conflict and Health, 15:11. 2021.
Background The use and implementation of novel tools for malaria control such as long lasting impregnated bednets (LLINs) and Indoor Residual Spraying (IRS) over the last decade has contributed to a substantial reduction in malaria burden globally. However numerous challenges ... |
|
Deficits of Public Deliberation in U.S. Oversight for Gene Edited OrganismsJ. Kuzma, Hastings Center Report, 51 Suppl 2:S25-s33. 2021.
Environmental releases of gene edited (GEdOs) and gene drive organisms (GDOs) will likely occur under conditions of high uncertainty and in complex socioecological systems. Therefore, public deliberation is especially important to account for diverse interpretations of safety, ... |
|
|
Public Deliberation about Gene Editing in the WildM. K. Gusmano, G. E. Kaebnick, K. J. Maschke, C. P. Neuhaus and B. C. Wills, Hastings Center Report, 51 Suppl 2:S2-s10. 2021.
Genetic editing technologies have long been used to modify domesticated nonhuman animals and plants. Recently, attention and funding have also been directed toward projects for modifying nonhuman organisms in the shared environment-that is, in the "wild." Interest in gene editing ... |
|
|
Empowering Indigenous Knowledge in Deliberations on Gene Editing in the WildR. Taitingfong and A. Ullah, Hastings Center Report, 51 Suppl 2:S74-s84. 2021.
Proposals to release genetically engineered organisms in the wild raise complex ethical issues related to their safe and equitable implementation. While there is broad agreement that community and public engagement is vital to decision-making in this context, more discussion is ... |
|
Public Perceptions Regarding Genomic Technologies Applied to Breeding Farm Animals: A Qualitative StudyF. Z. Naab, D. Coles, E. Goddard and L. J. Frewer, BioTech, 10. 2021.
The societal acceptability of different applications of genomic technologies to animal production systems will determine whether their innovation trajectories will reach the commercialisation stage. Importantly, technological implementation and commercialisation trajectories, ... |
|
New molecular genetic techniques: regulatory and societal considerationsNielsen, K. M., AREA-WIDE INTEGRATED PEST MANAGEMENT: Development and Field Application, 2021.
A rapidly expanding toolbox of techniques available for genome editing provides the basis for a new continuum in types of modifications that can be introduced into a genome and blur the bimodal GMO vs. non-GMO (genetically modified organism) divide. Site-directed nucleases (SDN) ... |
|
|
Genome editing and its applications for insect pest control: Curse or blessing?Hacker, I. , and Schetelig, M. F, AREA-WIDE INTEGRATED PEST MANAGEMENT: Development and Field Application, 2021.
Gene and genome editing are described as cutting-edge research tools with the potential to tackle urgent global challenges in the management of agricultural pests and human disease vectors such as mosquitoes. The field is defined by the chances and challenges to interlink the ... |
|
|
Barriers and facilitators of area-wide management including sterile insect technique application: The example of Queensland fruit flyMankad, A., Loechel, B., and Measham, P. F., AREA-WIDE INTEGRATED PEST MANAGEMENT: Development and Field Application, 2021.
The area-wide management (AWM) of highly mobile insect pests such as tephritid fruit flies requires an integrated understanding of technical, social and institutional processes that drive a coordinated approach within a defined area. Furthermore, the success of an AWM programme ... |
|
Podcast: Malaria Gene DriveS. Hartley, S. Neema and C. Opesen, University of Exeter Business School, 2021.
Professor Sarah Hartley and her two colleagues in Uganda, Stella Neema and Chris Opesen discuss gene drive research for malaria control. Funded by British Academy and Wellcome trust, their work is to understand the social science challenges around the development of this kind of ... |
|
A Household-Based Survey to Understand Factors Influencing Awareness, Attitudes and Knowledge towards Wolbachia-Aedes TechnologyL. T. Soh, Z. Ong, K. Vasquez, I. Chen, X. Li, W. Niah, C. Panchapakesan, A. Sheldenkar, S. Sim, L. C. Ng and M. O. Lwin, International Journal of Environmental Research and Public Health, 18. 2021.
In 2016, Singapore introduced the release of male Wolbachia-Aedes mosquitoes to complement vector control efforts and suppress Aedes aegypti mosquitoes in selected study sites. With ongoing expansion of Project Wolbachia-Singapore to cover larger areas, a household-based survey ... |
|
Gene drive and RNAi technologies: a bio-cultural review of next-generation tools for pest wasp management in New ZealandS. Palmer, P. K. Dearden, O. R. Mercier, A. King-Hunt and P. J. Lester, Journal of the Royal Society of New Zealand, 1-18. 2021.
There is a global need for novel, next-generation technologies and techniques to manage pest species. We review work on potential step-changing technologies for large landscape (>1000 hectares) pest management of social Vespula wasps. We also review M?ori perspectives on these ... |
|
|
Small-scale release of non-gene drive mosquitoes in Burkina Faso: from engagement implementation to assessment, a learning journeyL. Pare Toe, N. Barry, A. D. Ky, S. Kekele, W. Meda, K. Bayala, M. Drabo, D. Thizy and A. Diabate, Malaria Journal, 20:395. 2021.
This study provides a review of engagement activities relevant to field trials on non-gene drive genetically-modified mosquitoes as well as an assessment framework-using both qualitative and quantitative studies as well as an audit procedure. The latter was implemented to ... |
|
Oxitec and MosquitoMate in the United States: lessons for the future of gene drive mosquito controlC. E. Schairer, J. Najera, A. A. James, O. S. Akbari and C. S. Bloss, Pathogens and Global Health, 2021.
ABSTRACTIn response to growing concerns regarding mosquito-borne diseases, scientists are developing novel systems of vector control. Early examples include Oxitec?s OX513A genetically-engineered mosquito and MosquitoMate?s Wolbachia-infected mosquito, and systems using ... |
|
How do local communities participate in gene drive research?Outreach Network for Gene Drive Research, Outreach Network for Gene Drive Research, 2021.
|
|
Experimenting with co-development: a qualitative study of gene drive research for malaria control in MaliS. Hartley, K. Ledingham, R. Owen, S. Leonelli, S. Diarra and S. Diop, Social Science and Medicine, 2021.
Our findings suggest co-development is opening up previously expert-dominated spaces as researchers attempt to take responsibility for the societal implications of their work. However, its main function is as a project management tool to enable and instrumentally support ... |
|
The ethical scientist in a time of uncertaintyL. Zoloth, Cell, 184:1430-1439. 2021.
Using the example of gene drives for malaria control to explore the problem of deep uncertainty in biomedical research, I argue that profound uncertainty is an essential feature. Applying the language and presumptions of the discipline of philosophical ethics, I describe three ... |
|
Experts’ moral views on gene drive technologies: a qualitative interview studyN. de Graeff, K. R. Jongsma and A. L. Bredenoord, BMC Medical Ethics, 22:25. 2021.
Gene drive technologies (GDTs) promote the rapid spread of a particular genetic element within a population of non-human organisms. Potential applications of GDTs include the control of insect vectors, invasive species and agricultural pests. Whether, and if so, under what ... |
|
Demographic and psychographic drivers of public acceptance of novel invasive pest control technologiesF. Eppink, P. J. Walsh and E. MacDonald, Ecology and Society, 26. 2021.
Invasive mammals are a primary threat to New Zealand's endemic species. In remote areas, aerial delivery of poison is the preferred method of pest management, although it faces some public backlash. Novel pest control technologies are currently being investigated as alternatives ... |
|
Public attitudes towards synthetic biologyCSIRO, Synthetic Biology Future Science Platform, 2021.
A national survey has been conducted by CSIRO’s Synthetic Biology Future Science Platform as an important first step in measuring public attitudes towards synthetic biology. The survey draws on the views of more than 8,000 Australians, and researchers are examining the data to ... |
|
How to engage communities on a large scale? Lessons from World Mosquito Program in Rio de Janeiro, Brazil [version 2; peer review: 1 approved, 2 approved with reservations]G. B. Costa, R. Smithyman, S. L. O'Neill and L. A. Moreira, Gates Open Research, 2021.
Here we discuss and analyse the framework for community engagement implemented by the WMP in Brazil, during the large-scale deployment of the method in the municipalities of Niterói and Rio de Janeiro, Brazil. Our experience indicates that the community engagement work for ... |
|
Les Européens très critiques vis-à-vis du forçage génétiqueL. Duboua-Lorsch, EURACTIV, 2021.
Cette technique, qui vise à éradiquer ou modifier certaines espèces dites nuisibles, sera au cœur des négociations cette année, alors que se profile la COP15 sur la biodiversité. maginez un monde débarrassé d’insectes porteurs de maladies, de parasites agricoles, ... |
|
GENE DRIVE ACCEPTANCE SURVEYYouGov, Pollinis, 2021.
This representative survey was conducted by the international market research institute YouGov and polled 8.826 citizens from 8 EU countries in December 2020. It was commissioned by WeMove Europe, Save Our Seeds (Germany), Skiftet (Sweden), France Nature Environnement (FNE) ... |
|
Playing God and tampering with nature: popular labels for real concerns in synthetic biologyL. Carter, A. Mankad, E. V. Hobman and N. B. Porter, Transgenic Research, 2021.
We present the findings from a large Australian study (N = 4593) which suggests ‘playing God’ objections and their variants can be multilayered and, at times, accompanied by meaningful information about risk perceptions. We use qualitative analysis of ope |
|
|
Co‐developing a common glossary with stakeholders for engagement on new genetic approaches for malaria control in a local African settingE. Chemonges Wanyama, B. Dicko, L. Pare Toe, M. B. Coulibaly, N. Barry, K. Bayala Traore, A. Diabate, M. Drabo, J. K. Kayondo, S. Kekele, S. Kodio, A. D. Ky, R. R. Linga, E. Magala, W. I. Meda, S. Mukwaya, A. Namukwaya, B. Robinson, H. Samoura, K. Sanogo, Malaria Journal, 20:53. 2021.
Scientific terminologies are mainly lacking in local languages, yet when research activities involve international partnership, the question of technical jargon and its translation is crucial for effective and meaningful communication with stakeholders. Target Malaria, a ... |
|
Exploring Gene Drive Technologies in Agriculture, Biodiversity and Human DiseaseThe GBIRd Partnership and The GeneConvene Global Collaborative, Gene Drive Research Forum, 2021.
The GBIRd Partnership and The GeneConvene Global Collaborative recently collaborated through The Gene Drive Research Forum, to create and produce an engaging conversation between Drs. Fred Gould and Charles Godfray about gene drive technologies – the potential benefits and ... |
|
Next-generation tools to control biting midge populations and reduce pathogen transmissionP. Shults, L. W. Cohnstaedt, Z. N. Adelman and C. Brelsfoard, Parasites and Vectors, 14:31. 2021.
Biting midges of the genus Culicoides transmit disease-causing agents resulting in a significant economic impact on livestock industries in many parts of the world. Localized control efforts, such as removal of larval habitat or pesticide application, can be logistically ... |
|
|
Conservation pest control with new technologies: public perceptionsE. A. MacDonald, M. B. Neff, E. Edwards, F. Medvecky and J. Balanovic, Journal of the Royal Society of New Zealand, 2021.
We conducted eleven focus groups in New Zealand to explore three questions about novel technologies (gene drive and two others for comparison of pest control tools): (1) what are the risks/benefits? (2) how do they compare to current methods? and (3) who should be represented on ... |
|
Application of the Relationship-Based Model to Engagement for Field Trials of Genetically Engineered Malaria VectorsA. Kormos, G. C. Lanzaro, E. Bier, G. Dimopoulos, J. M. Marshall, J. Pinto, A. Aguiar dos Santos, A. Bacar, H. Sousa Pontes Sacramento Rompão and A. A. James, The American Journal of Tropical Medicine and Hygiene, 2020.
Although guidelines and recommendations for engagement for gene drives have recently been described, we argue here that communities and stakeholders should lead the planning, development, and implementation phases of engagement. The RBM provides a new approach to the development ... |
|
Scientists paved the way for field trials of gene-driven organismsK. Winslet, FLORIDA News Times, 2020.
The recent rise of gene drive research, accelerated by CRISPR-Cas9 gene editing technology, has brought about a wave of transformation throughout science.Developed with selected traits that have been genetically engineered to spread throughout the population, Gene Drive ... |
|
Scientists Set a Path for Field Trials of Gene Drive OrganismsM. Aguilera, UC San Diego News Center, 2020.
The modern rise of gene drive research, accelerated by CRISPR-Cas9 gene editing technology, has led to transformational waves rippling across science. Gene drive organisms (GDOs), developed with select traits that are genetically engineered to spread through a population, have ... |
|
Interdisciplinary development of a standardized introduction to gene drives for lay audiencesC. E. Schairer, C. Triplett, A. Buchman, O. S. Akbari and C. S. Bloss, BMC Medical Research Methodology, 20:15. 2020.
While there is wide consensus that the public should be consulted about emerging technology early in development, it is difficult to elicit public opinion about innovations unfamiliar to lay audiences. We sought public input on a program of research on genetic engineering to ... |
|
Engineered Gene Drives: Ecological, Environmental, and Societal ConcernsJ. Kuzma, GMOs: Implications for Biodiversity Conservation and Ecological Processes, 2020.
This chapter overviews the types, purposes, and potential impacts of gene drive organisms (GDOs) and discusses challenges with foreseeing and assessing these impacts prior to their environmental release. It concludes with a few examples of risk analysis methods and governance ... |
|
|
Transformation and slippage in co-production ambitions for global technology development: The case of gene driveK. Ledingham and S. Hartley, Environmental Science & Policy, 116:78-85. 2020.
Co-production is an increasingly popular framework for knowledge generation, evaluation and decision making. Despite its potential to open up decisions and practices to the input of others, co-production regularly falls short of its transformative ambitions. Through documentary ... |
|
FNIH Panel on Gene Drive Regulation Emphasizes Need for Local Community EngagementC. Rizk, GenomeWeb, 2020.
Genetically modified organisms are another topic of deep debate, with some activists agitating for and getting governments to implement deep restrictions on modified crops. More recently, GMO crops have started to regain public favor, particularly in countries where boosting the ... |
|
The promise of CRISPR and gene drive systems to end malaria in AfricaE. Gomez-Diaz, ARRIGE ORG, 2020.
Presentation by Elena Gómez Díaz (IPBLN-CSIC, Granada, Spain) at the ARRIGE 2020 meeting on "The promise of CRISPR and gene drive systems to end malaria in Africa". Discussion is included at the end of the Ruud de Maagd presentation.https://youtu.be/te3MJ8EZoes |
|
Outcome of a public consultation on the draft adequacy and sufficiency evaluation of existing EFSA guidelines for the molecular characterisation, environmental risk assessment and post-market environmental monitoring of genetically modified insects containing engineered gene drivesEuropean Food Safety Authority, Y. Devos, M. B. Bonsall, F. Nogué, K. Paraskevopoulos, E. A. Wimmer and L. G. Firbank, EFSA Supporting Publications, 17:1939E. 2020.
The European Food Safety Authority (EFSA) carried out an online public consultation to receive input from interested parties/persons on the draftscientific opinion on the adequacy and sufficiencyevaluation of existing guidelines for the molecular characterisation (MC), ... |
|
Brave New Planet: Reshaping Nature Through Gene DrivesE. Lander, Brave New Planet, 2020.
A new technology, called gene drives, has the power to spread any genetic instructions you wish across an entire animal or plant species in the wild. It might let us restore ecosystems ravaged by invasive species, or help species adapt to climate change. And, it might save ... |
|
Advances in genetic engineering test democracy’s capacity for good decision-makingN. Kofler and R. Taitingfong, Boston Globe, 2020.
New advances in genetic engineering and their application for environmental conservation and public health are further testing our democracy’s capacity for good decision-making. With minimal public input, the Environmental Protection Agency recently approved the release of ... |
|
Research and Innovation for biodiversity: what role for gene drive research?EP Intergroup CCBSD, European Bureau of Conservation and Development, 2020.
This webinar will provide an overview of how gene drive works and the problems it seeks to solve, introduce the most advanced research projects on gene drive in the sector of public health and conservation and present the work that international and European bodies such as WHO, ... |
|
Engineered Gene Drives: Policy and Regulatory Considerations Webinar Series by The GeneConvene Global Collaborative October-December 2020Hector Quemada and David O'Brochta, GeneConvene Global Collaborative, 2020.
In this series of webinars the regulatory and policy challenges of moving new innovative genetic biocontrol products such as gene drive technologies to the field will be featured. Each seminar will be ~60 minutes in length followed by questions and answers. |
|
Gene Drives – Mit gentechnischer Ausrottung Menschen und Natur schützen?Heinrich-Böll-Stiftung, Heinrich-Böll-Stiftung, 2020.
Am Beispiel von Gene Drives zur Malariabekämpfung soll in diesem Online-Seminar aufgezeigt werden, wie die Technologie funktioniert, wer sie entwickelt, finanziert und ihre Anwendung vorantreibt, welche Risiken sie birgt, wie in betroffenen Ländern darüber diskutiert und warum ... |
|
|
Engineered Gene Drives: Regulatory and Policy Considerations Webinar Series by The GeneConvene Global Collaborative October-December 2020Hector Quemada and David O'Brochta, GeneConvene Global Collaborative, 2020.
This is series of webinars the regulatory and policy challenges of moving new innovative genetic biocontrol products such as gene drive technologies to the field will be featured. |
|
ESA Position Statement on the Importance of Continued Innovation in Gene Drive TechnologyEntomological Society of America, Annals of the Entomological Society of America, 2020.
The risks and benefits of GDTs should be considered with the risks and benefits of continuing current pest control interventions, which may be comparatively less effective or pose exposure risks to human health and the environment. |
|
GeneConvene Global Collaborative Webinar Series Oct-Dec 2020Hector Quemada and David O'Brochta, GeneConvene Global Collaborative, 2020.
This is series of webinars the regulatory and policy challenges of moving new innovative genetic biocontrol products such as gene drive technologies to the field will be featured. |
|
Do Africans Want Genetically Modified Mosquitoes?U. Effiong, The Pursuit, 2020.
The recent publication by fellow Nigerian scientists—Patricia Okorie and colleagues—originally drew my attention to the issue of GMMs. |
|
Global citizen deliberation on genome editingJ. S. Dryzek, D. Nicol, S. Niemeyer, S. Pemberton, N. Curato, A. Bächtiger, P. Batterham, B. Bedsted, S. Burall, M. Burgess, G. Burgio, Y. Castelfranchi, H. Chneiweiss, G. Church, M. Crossley, J. de Vries, M. Farooque, M. Hammond, B. He, R. Mendonça, J., Science, 369:1435. 2020.
Here we show how, as the global governance vacuum is filled, deliberation by a global citizens' assembly should play a role, for legitimate and effective governance. |
|
Responsible innovation in biotechnology: Stakeholder attitudes and implications for research policyP. Roberts, J. Herkert and J. Kuzma, Elementa, 2020.
Using a mixed methods approach, we analyzed the attitudes of different biotechnology stakeholders, particularly those working in areas related to genetically modified organisms (GMOs) in agriculture and the environment, towards the principles and practices of RI. Homogenous focus ... |
|
Do Africans need genetically modified mosquitoes?genetically modified, mosquito, oxitec, autocidal, SIT, perspective, malaria, gene drive synthetic, engagement,, Mail and Guardian, 2020.
The following is an updated version of an article I wrote for the University of Michigan Risk Science Centre a while ago: |
|
Global Governing Bodies: A Pathway for Gene Drive Governance for Vector Mosquito ControlA. Kelsey, D. Stillinger, T. B. Pham, J. Murphy, S. Firth and R. Carballar-Lejarazú, American Journal of Tropical Medicine and Hygiene, 2020.
We examined the current institutions and governing bodies among various continents that could have an impact on gene drive governance or the potential to adapt to its future use. Possible governance strategies also are proposed that seek to bridge gaps and promote an ethically ... |
|
Exploring gene drive’s role in fight against malariaJ. Conrow, Genetic Literacy Project, 2020.
J. Conrow (2020) Genetic Literacy Project. An international initiative has formed to ensure that gene drive technology gets a chance to prove its mettle in the quest to control malaria. |
|
|
Biotechnologies in pest wasp control: taking the sting out of pest management for Māori businesses?S. Palmer and O. R. Mercier, New Genetics and Society, 2020.
A Maori-centered mixed-method study gauged the perceptions of eight Maori businesses about the potential use of five specific new biotechnological controls in pest management. |
|
Après les OGM, la nouvelle technique du forçage génétique inquiète écologistes et scientifiquesH. Leussier, Reporterre, 2020.
Les organismes issus du forçage génétique peuvent transmettre, sans autre intervention humaine, des gènes modifiés à tous leurs descendants. Cette technique permettrait d’éradiquer des espèces nuisibles, comme certains moustiques vecteurs de la malaria. Mais des ... |
|
Release of genetically modified mosquitoes in the Florida Keys put on holdD. Goodhue, Miami Herald, 2020.
Opponents of a plan to release millions of genetically modified mosquitoes in the Florida Keys landed a temporary win on Tuesday. |
|
Genome Editing in Food and Farming: Risks and unexpected consequencesJ. Cotter and D. Perls, Canadian Biotechnology Action Network, 2020.
J. Cotter and D. Perls (2020). Canadian Biotechnology Action Network. In this report, we provide an overview of genome editing techniques being explored in agriculture, and the range of potential unexpected effects that can arise from them. The report draws on recent scientific ... |
|
Translating gene drive science to promote linguistic diversity in community and stakeholder engagementC. Cheung, S. Gamez, R. Carballar-Lejarazú, V. Ferman, V. N. Vásquez, G. Terradas, J. Ishikawa, C. E. Schairer, E. Bier, J. M. Marshall, A. A. James, O. S. Akbari and C. S. Bloss, Global Public Health, 2020.
Information about genetic engineering (GE) for vector control in the United States is disseminated primarily in English, though non-English speakers are equally, and in some geographic regions even more affected by such technologies. Non-English-speaking publics should have equal ... |
|
Gene Drive Webinars -ENSSER, CSS, VDW and SCEuropean Network of Scientists for Social and Environmental Responsibility, , 2020.
This series of 5 Webinars by some of the authors of the interdisciplinary Gene Drive Report (2019) and were organised by four organisations of independent scientists: the European Network of Scientists for Social and Environmental Responsibility (ENSSER), Critical Scientists ... |
|
Jonathan Latham on Gene Drives and the Gates FoundationJames Corbett, The Corbett Report, 2020.
Jonathan Latham of Independent Science News joins us to discuss his 2017 article, “Gates Foundation Hired PR Firm to Manipulate UN Over Gene Drives.” We talk about gene drives, the dangers inherent in this technology, how the UN is involved, and why the Gates Foundation and ... |
|
|
Motivations and expectations driving community participation in entomological research projects: Target Malaria as a case study in Bana, Western Burkina FasoN. Barry, P. Toé, L. Pare Toe, J. Lezaun, M. Drabo, R. K. Dabiré and A. Diabate, Malaria Journal, 19:199. 2020.
Most field entomology research projects require active participation by local community members. Since 2012, Target Malaria, a not-for-profit research consortium, has been working with residents in the village of Bana, in Western Burkina Faso, in various studies involving ... |
|
|
Position Paper on Integrated Vector Management: Strengthening AU Members’ Regulatory Capacities for Responsible Research Towards Elimination of Malaria in AfricaAfrican Union Development Agency - NEPAD, AUDA-NEPAD, 2020.
Africa continues to bear a heavy brunt of the malaria which is a disease transmitted by the female Anopheles mosquito. Thousands of lives, mostly of young children, are lost every year; which undermines efforts deployed at various levels for increased life expectancy and improved ... |
|
Public Opinion Towards Gene Drive as a Pest Control Approach for Biodiversity Conservation and the Association of Underlying WorldviewsE. A. MacDonald, J. Balanovic, E. D. Edwards, W. Abrahamse, B. Frame, A. Greenaway, R. Kannemeyer, N. Kirk, F. Medvecky, T. L. Milfont, J. C. Russell and D. M. Tompkins, Environmental Communication-a Journal of Nature and Culture, 15:1-16. 2020.
Synthetic gene drive approaches are nascent technologies with potential applicability for pest control for conservation purposes. Responsible science mandates that society be engaged in a dialogue over new technology, particularly where there exist global ramifications as with ... |
|
|
Public Opinion Towards Gene Drive as a Pest Control Approach for Biodiversity Conservation and the Association of Underlying WorldviewsE. A. MacDonald, J. Balanovic, E. D. Edwards, W. Abrahamse, B. Frame, A. Greenaway, R. Kannemeyer, N. Kirk, F. Medvecky, T. L. Milfont, J. C. Russell and D. M. Tompkins, Environmental Communication, 14:904-918. 2020.
Synthetic gene drive approaches are nascent technologies with potential applicability for pest control for conservation purposes. Responsible science mandates that society be engaged in a dialogue over new technology, particularly where there exist global ramifications as with ... |
|
A typology of community and stakeholder engagement based on documented examples in the field of novel vector controlC. E. Schairer, R. Taitingfong, O. S. Akbari and C. S. Bloss, PLoS Neglected Tropical Diseases, 13:e0007863. 2019.
Background Despite broad consensus on the importance of community and stakeholder engagement (CSE) for guiding the development, regulation, field testing, and deployment of emerging vector control technologies (such as genetically engineered insects), the types of activities ... |
|
Peri-Urban Community Attitudes towards Codling Moth Trapping and Suppression Using the Sterile Insect Technique in New ZealandG. Paterson, G. L. W. Perry, J. T. S. Walker and D. M. Suckling, Insects, 10. 2019.
New, more socially-acceptable technologies are being developed to suppress horticultural pests, because suppression is technically difficult with current technologies, especially in urban areas. One technique involves the release of sterile insects to prevent offspring in the ... |
|
Autonomy of Nations and Indigenous Peoples and the Environmental Release of Genetically Engineered Animals with Gene DrivesZ. Meghani, Global Policy, 10:554-568. 2019.
This article contends that the environmental release of genetically engineered (GE) animals with heritable traits that are patented will present a challenge to the efforts of nations and indigenous peoples to engage in self-determination. The environmental release of such animals ... |
|
Gene Drives in Africa: Civil Society Speaks OutAfrican Centre for Biodiversity, African Centre for Biodiversity, 2019.
On Monday 1st July 2019, Target Malaria announced the release of genetically modified (GM) sterile male mosquitoes in Bana, a village in Burkina Faso – the first GM insect to be released in Africa. This is Phase I – by Phase III, Target Malaria aims to release gene drive ... |
|
RISCOS BIOTECNOLÓGICOS AMBIENTAIS E PARTICIPAÇÃO SOCIAL: POR UMA GESTÃO DEMOCRÁTICA DA BIOTECNOLOGIA GENE DRIVE NA ATUAÇÃO DA CTNBIOL. C. Rodrigues, Revista Jurídica (FURB), 22. 2019.
This research aims to study the way in which the environmental risks of Gene Drive biotechnology challenge forms of effective social participation, inserted in the management of biotechnological risks, whose responsibility lies with the organs ... |
|
The ethical implications of population suppression and the irreversibility of gene drivesJ. Kim, International Journal of Life Sciences Research, 2018.
This paper aims to examine the current situation by presenting important ethical arguments that include Chardin’s principle of irreversibility and Weiss’ beliefs on intergenerational equity, ideals upheld by the United Nations |
|
|
Gene drives and the management of agricultural pestsR. F. Medina, Journal of Responsible Innovation, 5:S255-S262. 2018.
Like all pest control strategies, gene drives are not hazard-free. Ecological risk assessment of gene drives designed to control agricultural pests should be conducted before their deployment. The present commentary provides some thoughts on some of the issues one should consider ... |
|
|
SummaryCommittee on Gene Drive Research in Non-Human Organisms: Recommendations for Responsible, Journal of Responsible Innovation, 5:S243-S254. 2018.
Scientists have studied gene drives for more than 50 years. The development of a powerful genome editing tool in 2012, CRISPR/Cas9,1 led to recent breakthroughs in gene drive research that built on that half century’s worth of knowledge, and stimulated new discussion of the ... |
|
|
Anomaly handling and the politics of gene drivesS. W. Evans and M. J. Palmer, Journal of Responsible Innovation, 5:S223-S242. 2018.
Decisions about the development and use of gene drives are framing broader debates about the need for fundamental changes to biotechnology regulatory systems. We summarize this debate and describe how gene drives are being constructed as potential anomalies within the regulatory ... |
|
|
Identifying and detecting potentially adverse ecological outcomes associated with the release of gene-drive modified organismsK. R. Hayes, G. R. Hosack, G. V. Dana, S. D. Foster, J. H. Ford, R. Thresher, A. Ickowicz, D. Peel, M. Tizard, P. De Barro, T. Strive and J. M. Dambacher, Journal of Responsible Innovation, 5:S139-S158. 2018.
In this paper, we outline methods to identify hazards and detect potentially adverse ecological outcomes at the individual (genotype, phenotype), population, community and ecosystem level, when progressing Gene Drive Modified Organisms through a phased test and release pathway. ... |
|
|
Harnessing gene driveJ. Min, A. L. Smidler, D. Najjar and K. M. Esvelt, Journal of Responsible Innovation, 5. 2018.
Determining whether, when, and how to develop gene drive interventions responsibly will be a defining challenge of our time. Here we describe capabilities, safeguards, applications, and opportunities relevant to gene drive technologies. |
|
|
A roadmap for gene drives: using institutional analysis and development to frame research needs and governance in a systems contextJ. Kuzma, F. Gould, Z. Brown, J. Collins, J. Delborne, E. Frow, K. Esvelt, D. Guston, C. Leitschuh, K. Oye and S. Stauffer, Journal of Responsible Innovation, 5:S13-S39. 2018.
This paper reports on a workshop held in February 2016 to explore the complex intersection of political, economic, ethical, and ecological risk issues associated with gene drives. Workshop participants were encouraged to use systems thinking and mapping to describe the ... |
|
|
Mapping research and governance needs for gene drivesJ. Delborne, J. Kuzma, F. Gould, E. Frow, C. Leitschuh and J. Sudweeks, Journal of Responsible Innovation, 5:S4-S12. 2018.
This special issue represents both deep and broad thinking about gene drives. The papers were first drafted nearly two years ago, and since then have been reviewed and revised to flesh out key arguments and take account of ongoing developments in the field. This field has moved ... |
|
|
Gene drives and the expanding horizon of governanceE. Fisher, Journal of Responsible Innovation, 5:S1-S3. 2018.
Like other areas of emerging science and technology that trigger prolonged public debate over their transformative prospects, gene drives simultaneously generate prospects for new knowledge, hoped-for benefits, and formidable concerns. Their ability to bias inheritance of and in ... |
|
|
Informed consent in field trials of gene-drive mosquitoesP. A. Kolopack and J. V. Lavery, Gates Open Research, 2017.
We argue that informed consent from individual research participants in gene drive trials may be required: (1) when blood and other forms of clinical data are collected from them, as will likely be the case in some studies involving epidemiological endpoints, such as the ... |
|
|
The potential for the use of gene drives for pest control in New Zealand: a perspectiveP. K. Dearden, N. J. Gemmell, O. R. Mercier, P. J. Lester, M. J. Scott, R. D. Newcomb, T. R. Buckley, J. M. E. Jacobs, S. G. Goldson and D. R. Penman, Journal of the Royal Society of New Zealand, 48:225-244. 2017.
Here we describe the current state of gene drive technologies and present a series of examples to examine the potential benefits and problems arising from gene drive approaches for pest control in New Zealand. |
|
Using CRISPR-based gene drive for agriculture pest controlV. Courtier-Orgogozo, B. Morizot and C. Boëte, EMBO Reports, 18:1481. 2017.
The authors respond to comments to their publication 10.15252/embr.201744205 |
|
Perceptions and recommendations by scientists for a potential release of genetically modified mosquitoes in NigeriaP. N. Okorie, J. M. Marshall, O. M. Akpa and O. G. Ademowo, Malaria Journal, 13:154. 2014.
The use of genetically modified mosquitoes (GMMs) for the control of malaria and other mosquito-borne diseases has been proposed in malaria-endemic countries, such as Nigeria, which has the largest burden in Africa. Scientists are major stakeholders whose opinions and perceptions ... |
