Keywords: engineered underdominance

Design and analysis of CRISPR-based underdominance toxin-antidote gene drives

J. Champer, S. E. Champer, I. K. Kim, A. G. Clark and P. W. Messer,  Evolutionary Applications,  18. 2020.
We model drives which target essential genes that are either haplosufficient or haplolethal, using nuclease promoters with expression restricted to the germline, promoters that additionally result in cleavage activity in the early embryo from maternal deposition, and promoters ...
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Split drive killer-rescue provides a novel threshold-dependent gene drive

M. P. Edgington, T. Harvey-Samuel and L. Alphey,  Scientific Reports,  10:13. 2020.
We show that although end-joining repair mechanisms may cause the system to break down, under certain conditions, it should persist over time scales relevant for genetic control programs. The potential of such a system to provide localised population suppression via sex ratio ...
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Genetic control of invasive fish: technological options and its role in integrated pest management

R. E. Thresher, K. Hayes, N. J. Bax, J. Teem, T. J. Benfey and F. Gould,  Biological Invasions,  16:1201-1216. 2013.
Genetic options for the control of invasive fishes were recently reviewed and synthesized at a 2010 international symposium, held in Minneapolis/St. Paul, MN, USA. The only option currently available "off-the-shelf'' is triploidy, which can be used to produce sterile males for a ...
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