Keywords: epidemiology
|
Population replacement gene drive characteristics for malaria elimination in a range of seasonal transmission settings: a modeling studyS. Leung, N. Windbichler, E. Wenger, C. Bever and P. Selvaraj, bioRxiv, 2021.11.01.466856. 2021.
Genetically engineering mosquitoes is a promising new vector control strategy to reinvigorate the fight against malaria in Sub-Saharan Africa. Using an agent-based model of malaria transmission with vector genetics, we examine the impacts of releasing population-replacement gene ... |
|
MGDrivE 2: A simulation framework for gene drive systems incorporating seasonality and epidemiological dynamicsS. L. Wu, J. B. Bennett, C. H. Sánchez, A. J. Dolgert, T. M. León and J. M. Marshall, PLoS Comput Biol, 17:e1009030. 2021.
We present MGDrivE 2 (Mosquito Gene Drive Explorer 2): a significant development from the MGDrivE 1 simulation framework that investigates the population dynamics of a variety of gene drive architectures and their spread through spatially-explicit mosquito populations. Key ... |
|
Ecological effects on underdominance threshold drives for vector controlD. Khamis, C. El Mouden, K. Kura and M. B. Bonsall, Journal of Theoretical Biology, 456:1-15. 2018.
Here, ecological and epidemiological dynamics are coupled to a model of mosquito genetics to investigate theoretically the impact of different types of underdominance gene drive on disease prevalence. We model systems with two engineered alleles carried either on the same pair ... |
|
Modelling the spatial spread of a homing endonuclease gene in a mosquito populationNorth, AB, A.; Godfray, H. C. J., Journal of Applied Ecology, 50:1216-1225. 2013.
Homing endonuclease genes (HEGs) exist naturally in many single-celled organisms and can show extremely strong genetic drive allowing them to spread through populations into which they are introduced. They are being investigated as tools to manipulate the populations of important ... |
