Keywords: epidemiology

MGDrivE 3: A decoupled vector-human framework for epidemiological simulation of mosquito genetic control tools and their surveillance

Mondal A, Sánchez C. HM, Marshall JM,  PLoS Computational Biology,  20. 2024.
Novel mosquito genetic control tools, such as CRISPR-based gene drives, hold great promise in reducing the global burden of vector-borne diseases. As these technologies advance through the research and development pipeline, there is a growing need for modeling frameworks ...
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Effectiveness evaluation of mosquito suppression strategies on dengue transmission under changing temperature and precipitation

Kaihui Liu, Shuanghui Fang, Qiong Li, et al.,  Acta Tropica,  2024.

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The mosquito knows no borders: Regional challenges for global confrontation in the dengue battle

Barçante JMdP, Cherem J,  PLoS Neglected Tropical Diseases,  18. 2024.
Dengue fever is a neglected disease with a global impact, and its incidence and geographical reach are rapidly expanding. Global warming marked by higher average temperatures, precipitation, and longer periods of drought could prompt a record number of dengue fever infections ...
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Population replacement gene drive characteristics for malaria elimination in a range of seasonal transmission settings: a modeling study

S. Leung, N. Windbichler, E. Wenger, C. Bever and P. Selvaraj,  bioRxiv,  2021.11.01.466856. 2021.
Genetically engineering mosquitoes is a promising new vector control strategy to reinvigorate the fight against malaria in Sub-Saharan Africa. Using an agent-based model of malaria transmission with vector genetics, we examine the impacts of releasing population-replacement gene ...
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MGDrivE 2: A simulation framework for gene drive systems incorporating seasonality and epidemiological dynamics

S. L. Wu, J. B. Bennett, C. H. Sánchez, A. J. Dolgert, T. M. León and J. M. Marshall,  PLoS Comput Biol,  17:e1009030. 2021.
We present MGDrivE 2 (Mosquito Gene Drive Explorer 2): a significant development from the MGDrivE 1 simulation framework that investigates the population dynamics of a variety of gene drive architectures and their spread through spatially-explicit mosquito populations. Key ...
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Ecological effects on underdominance threshold drives for vector control

D. Khamis, C. El Mouden, K. Kura and M. B. Bonsall,  Journal of Theoretical Biology,  456:1-15. 2018.
Here, ecological and epidemiological dynamics are coupled to a model of mosquito genetics to investigate theoretically the impact of different types of underdominance gene drive on disease prevalence. We model systems with two engineered alleles carried either on the same pair ...
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Modelling the spatial spread of a homing endonuclease gene in a mosquito population

North, AB, A.; Godfray, H. C. J.,  Journal of Applied Ecology,  50:1216-1225. 2013.
Homing endonuclease genes (HEGs) exist naturally in many single-celled organisms and can show extremely strong genetic drive allowing them to spread through populations into which they are introduced. They are being investigated as tools to manipulate the populations of important ...
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