
Keywords: Evolutionary genetics
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Current CRISPR gene drive systems are likely to be highly invasive in wild populationsNoble, CA, Ben; Church, George M.; Esvelt, Kevin M.; Nowak, Martin A., eLife, 7:e33423. 2018.![]() Recent reports have suggested that self-propagating CRISPR-based gene drive systems are unlikely to efficiently invade wild populations due to drive-resistant alleles that prevent cutting. Here we develop mathematical models based on existing empirical data to explicitly test ... Keywords: CRISPR, Evolutionary dynamics, Evolutionary genetics, Gene drive, gene drive guidance, gene drive models, gene drive safety, gene drive synthetic |

Contact
David O’Brochta
Foundation for the
National Institutes of Health
geneconvenevi@fnih.org
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