CRISPR/Cas9 -mediated gene knockout of Anopheles gambiae FREP1 suppresses malaria parasite infectionDong, YS, Maria L.; Marois, Eric; Dimopoulos, George, PLOS Pathogens, 14:e1006898. 2018.
The causative agent of malaria, Plasmodium, has to complete a complex infection cycle in the Anopheles gambiae mosquito vector in order to reach the salivary gland from where it can be transmitted to a human host. The parasite’s development in the mosquito relies on numerous ...
Keywords: Anopheles, Cas9, CRISPR, FREP1, immunity, mosquito