Keywords: gene drive ecology

A 2017 horizon scan of emerging issues for global conservation and biological diversity

Sutherland, WJB, P.; Broad, S.; Clout, M.; Connor, B.; Cote, I. M.; Dicks, L. V.; Doran, H.; Entwistle, A. C.; Fleishman, E.; Fox, M.; Gaston, K. J.; Gibbons, D. W.; Jiang, Z.; Keim, B.; Lickorish, F. A.; Markillie, P.; Monk, K. A.; Pearce-Higgins, J. W.; Peck, L. S.; Pretty, J.; Spalding, M. D.; Tonneijck, F. H.; Wintle, B. C.; Ockendon, N.,  Trends in Ecology & Evolution,  32:31-40. 2019.
We present the results of our eighth annual horizon scan of emerging issues likely to affect global biological diversity, the environment, and conservation efforts in the future. The potential effects of these novel issues might not yet be fully recognized or understood by the ...
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A male-biased primary sex ratio and larval mortality in Eucheira socialis (Lepidoptera : Pieridae)

Underwood, DLAS, A. M.,  Evolutionary Ecology Research,  1:703-717. 1999.
We investigated the sex ratio and sex-biased mortality in the Mexican pierid butterfly, Eucheira socialis westwoodi. We studied two populations between 1990 and 1997 along Mexico Highway 40, which runs from Mazatlan, Sinaloa to Durango, Durango, Populations occurring between km ...
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A natural gene drive system influences bovine tuberculosis susceptibility in African buffalo: Possible implications for disease management

P. van Hooft, W. M. Getz, B. J. Greyling and A. D. S. Bastos,  PLoS One,  14:e0221168. 2019.
Bovine tuberculosis (BTB) is endemic to the African buffalo (Syncerus caffer) of Hluhluwe-iMfolozi Park (HiP) and Kruger National Park, South Africa. In HiP, the disease has been actively managed since 1999 through a test-and-cull procedure targeting BTB-positive buffalo. Prior ...
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A novel meiotic drive locus almost completely distorts segregation in Mimulus (monkeyflower) hybrids

Fishman, LW, J. H.,  Genetics,  169:347-353. 2005.
We report the discovery, mapping, and characterization of a meiotic drive locus (D) exhibiting nearly 100% nonrandom transmission in hybrids between two species of yellow monkeyflowers, outcrossing Mimulus guttatus and selfing M. nasutus. Only 1% of F-2 hybrids were M. nasutus ...
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Adaptation for horizontal transfer in a homing endonuclease

Koufopanou, VG, M. R.; Burt, A.,  Molecular Biology and Evolution,  19:239-246. 2002.
Selfish genes of no function other than self-propagation are susceptible to degeneration if they become fixed in a population. and regular transfer to new species may be the only means for their long-term persistence. To test this idea we surveyed 24 species of yeast for VDE, a ...
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Alternative strategies for mosquito-borne arbovirus control

Achee, NLG, J. P.; Vatandoost, H.; Seixas, G.; Pinto, J.; Ching-Ng, L.; Martins, A. J.; Juntarajumnong, W.; Corbel, V.; Gouagna, C.; David, J. P.; Logan, J. G.; Orsborne, J.; Marois, E.; Devine, G. J.; Vontas, J.,  PLOS Neglected Tropical Diseases,  13:e0006822. 2019.
Mosquito-borne virusessuch as Zika, chikungunya, dengue fever, and yellow fever, among othersare of global importance. Although vaccine development for prevention of mosquito-borne arbovirus infections has been a focus, mitigation strategies continue to rely on vector control. ...
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An assessment of the immune costs associated with meiotic drive elements in Drosophila

Lea, J. K. and R. L. Unckless,  Proceedings of the Royal Society B: Biological Sciences,  286:20191534. 2019.
Most organisms are constantly adapting to pathogens and parasites that exploit their host for their own benefit. Less studied, but perhaps more ubiquitous, are intragenomic parasites or selfish genetic elements. These include transposable elements, selfish B chromosomes and ...
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Analysis of irradiated Drosophila populations for meiotic drive

Novitski, EH, G. D.,  Nature,  190:989-990. 1961.
The existence of chromosomes or alleles that are represented in the gametes of a heterozygote with a frequency greater than the expected 50 percent is now well established for a variety of species. The immediate population result of introducing such a chromosome or allele must ...
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Analysis of segregation distortion and its relationship to hybrid barriers in rice

Reflinur, K, B.; Jang, S. M.; Chu, S. H.; Bordiya, Y.; Akter, M. B.; Lee, J.; Chin, J. H.; Koh, H. J.,  Rice,  7:3. 2014.
Segregation distortion (SD) is a frequently observed occurrence in mapping populations generated from crosses involving divergent genotypes. In the present study, ten genetic linkage maps constructed from reciprocal F-2 and BC1F1 mapping populations derived from the parents ...
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Ancient gene drives: an evolutionary paradox

Price, T. A. R., R. Verspoor and N. Wedell,  Proceedings of the Royal Society B: Biological Sciences,  286:20192267. 2019.
Selfish genetic elements such as selfish chromosomes increase their transmission rate relative to the rest of the genome and can generate substantial cost to the organisms that carry them. Such segregation distorters are predicted to either reach fixation (potentially causing ...
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Cage trials using an endogenous meiotic drive gene in the mosquito Aedes aegypti to promote population replacement

Cha, SJM, A.; Chadee, D. D.; Severson, D. W.,  American Journal of Tropical Medicine and Hygiene,  74:62-68. 2006.
Control of arthropod-borne diseases based on population replacement with genetically modified noncompetent vectors has been proposed as a promising alternative to conventional control strategies. Due to likely fitness costs associated with vectors manipulated to carry ...
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Carrying a selfish genetic element predicts increased migration propensity in free-living wild house mice

Runge, J-NL, Anna K.,  Proceedings of the Royal Society B: Biological Sciences,  285:20181333. 2018.
Life is built on cooperation between genes, which makes it vulnerable to parasitism. Selfish genetic elements that exploit this cooperation can achieve large fitness gains by increasing their transmission relative to the rest of the genome. This leads to counter-adaptations that ...
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Centromere-associated female meiotic drive entails male fitness costs in Monkeyflowers

Fishman, LS, A.,  Science,  322:1559-1562. 2008.
Female meiotic drive, in which paired chromosomes compete for access to the egg, is a potentially powerful but rarely documented evolutionary force. In interspecific monkeyflower ( Mimulus) hybrids, a driving M. guttatus allele ( D) exhibits a 98: 2 transmission advantage via ...
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Centromere-associated meiotic drive and female fitness variation in Mimulus

Fishman, LK, J. K.,  Evolution,  69:1208-1218. 2015.
Female meiotic drive, in which chromosomal variants preferentially segregate to the egg pole during asymmetric female meiosis, is a theoretically pervasive but still mysterious form of selfish evolution. Like other selfish genetic elements, driving chromosomes may be maintained ...
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Comparative analysis of regions with distorted segregation in three diploid populations of potato

Manrique-Carpintero, NCC, J. J.; Veilleux, R. E.; Buell, C. R.; Douches, D. S.,  G3-Genes Genomes Genetics,  6:2617-2628. 2016.
Genes associated with gametic and zygotic selection could underlie segregation distortion, observed as alterations of expected Mendelian genotypic frequencies in mapping populations. We studied highly dense genetic maps based on single nucleotide polymorphisms to elucidate the ...
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Complex genetic nature of sex-independent transmission ratio distortion in Asian rice species: the involvement of unlinked modifiers and sex-specific mechanisms

Koide, YS, Y.; Ikenaga, M.; Sawamura, N.; Matsubara, K.; Onishi, K.; Kanazawa, A.; Sano, Y.,  Heredity,  108:242-247. 2012.
Transmission ratio distortion (TRD), in which one allele is transmitted more frequently than the opposite allele, is presumed to act as a driving force in the emergence of a reproductive barrier. TRD acting in a sex-specific manner has been frequently observed in interspecific ...
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Detrimental effects of an autosomal selfish genetic element on sperm competitiveness in house mice

Sutter, AL, A. K.,  Proceedings of the Royal Society B-Biological Sciences,  282:1-8. 2015.
Female multiple mating (polyandry) is widespread across many animal taxa and indirect genetic benefits are a major evolutionary force favouring polyandry. An incentive for polyandry arises when multiple mating leads to sperm competition that disadvantages sperm from genetically ...
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Does Stellate cause meiotic drive in Drosophila melanogaster?

Belloni, MT, P.; Bozzetti, M. P.; Palumbo, G.; Robbins, L. G.,  Genetics,  161:1551-1559. 2002.
Drosophila melanogaster males deficient for the crystal (cry) locus of the Y chromosome that carry between 15 and 60 copies of the X-linked Stellate (Ste) gene are semisterile, have elevated levels of nondisjunction, produce distorted sperm genotype ratios (meiotic drive), and ...
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Dolly the sheep scientists hope DNA editing can wipe out grey squirrels

McLaughlin, M.,  The Scotsman,  2020.
They have been poisoned, shot at, and stumbled into traps laid by those who regard them as a ruinous blight on the country’s woodland and wildlife. But now, the grey squirrel is facing arguably its biggest threat yet, with plans to harness the cutting edge of genetic science ...
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Editing nature: Local roots of global governance

Kofler, NC, James P.; Kuzma, Jennifer; Marris, Emma; Esvelt, Kevin; Nelson, Michael Paul; Newhouse, Andrew; Rothschild, Lynn J.; Vigliotti, Vivian S.; Semenov, Misha; Jacobsen, Rowan; Dahlman, James E.; Prince, Shannon; Caccone, Adalgisa; Brown, Timothy; Schmitz, Oswald J.,  Science,  362:527. 2018.
The end of malaria. Restored island habitats. Resiliency for species threatened by climate change. Many envisioned environmental applications of newly developed gene-editing techniques such as CRISPR might provide profound benefits for ecosystems and society. But depending on the ...
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Editing nature: Local roots of global governance

Kofler, N.C., James P.; Kuzma, Jennifer; Marris, Emma; Esvelt, Kevin; Nelson, Michael Paul; Newhouse, Andrew; Rothschild, Lynn J.; Vigliotti, Vivian S.; Semenov, Misha; Jacobsen, Rowan; Dahlman, James E.; Prince, Shannon; Caccone, Adalgisa; Brown, Timothy,  Science,  2018.

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Engineered integrative and conjugative elements for efficient and inducible DNA transfer to undomesticated bacteria

Brophy, JANT, Alexander J.; Adams, Bryn L.; Renberg, Rebecca L.; Stratis-Cullum, Dimitra N.; Grossman, Alan D.; Voigt, Christopher A.,  Nature Microbiology,  3:1043-1053. 2018.
Engineering microorganisms to promote human or plant health will require manipulation of robust bacteria that are capable of surviving in harsh, competitive environments. Genetic engineering of undomesticated bacteria can be limited by an inability to transfer DNA into the cell. ...
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Evaluating active genetic options for the control of Sea Lampreys (Petromyzon marinus) in the Laurentian Great Lakes

Thresher, REJ, Michael; Drake, D. Andrew,  Canadian Journal of Fisheries and Aquatic Sciences,  76:1186-1202. 2018.
For more than two decades the Great Lakes Fishery Commission has sought tactics to complement, and potentially replace, the use of barriers and lampricides to control Sea Lamprey in the Great Lakes, but thus far without success. This paper examines the potential of modern genetic ...
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Evaluating the Probability of CRISPR-based Gene Drive Contaminating Another Species

Courtier-Orgogozo, VD, Antoine; Gouyon, Pierre-Henri; Boëte, Christophe,  bioRxiv,  776609:27. 2019.
The probability D that a given CRISPR-based gene drive element contaminates another, non-target species can be estimated by the following Drive Risk Assessment Quantitative Estimate (DRAQUE) Equation: D = (hyb+transf).express.cut.flank.immune.nonextinct withhyb = probability of ...
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Evaluating the Probability of CRISPR-based Gene Drive Contaminating Another Species

V. Courtier-Orgogozo, A. Danchin, P.-H. Gouyon and C. Boëte,  Evolutionary Applications,  Early Online. 2020.
he probability D that a given CRISPR-based gene drive element contaminates another, non-target species can be estimated by the following Drive Risk Assessment Quantitative Estimate (DRAQUE) Equation: D = (hyb + transf).express.cut.flank.immune.nonextinct with ...
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Evolution of driving X chromosomes and resistance factors in experimental populations of Drosophila simulans

Capillon, CA, A.,  Evolution,  53:506-517. 1999.
Sex-ratio drive is a particular case of meiotic drive, described in several Drosophila species, that causes males bearing driving X chromosome to produce a large excess of females in their progeny. In Drosophila simulans, driving X chromosomes and resistance factors located on ...
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Evolution of Resistance Against CRISPR/Cas9 Gene Drive

Unckless, RLC, A. G.; Messer, P. W.,  Genetics,  205:827-841. 2017.
CRISPR/Cas9 gene drive (CGD) promises to be a highly adaptable approach for spreading genetically engineered alleles throughout a species, even if those alleles impair reproductive success. CGD has been shown to be effective in laboratory crosses of insects, yet it remains ...
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Experimental manipulation of selfish genetic elements links genes to microbial community function

S. D. Quistad, G. Doulcier and P. B. Rainey,  Philosophical Transactions of the Royal Society B-Biological Sciences,  375:12. 2020.
Microbial communities underpin the Earth's biological and geochemical processes, but their complexity hampers understanding. Motivated by the challenge of diversity and the need to forge ways of capturing dynamical behaviour connecting genes to function, biologically independent ...
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Experimental population-genetics of meiotic drive systems .1: Pseudo-Y chromosomal drive as a means of eliminating cage populations of Drosophila melanogaster

Lyttle, TW,  Genetics,  86:413-445. 1977.
The experimental population genetics of Y-chromosome drive in Drosophila; melanogasier is approximated by studying the behavior of T(Y;S),SD lines.; These exhibit “pseudo-Y” drive through the effective coupling of the Y chromosome; to the second chromosome meiotic drive ...
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Expression of meiotic drive elements Spore Killer-2 and Spore Killer-3 in asci of Neurospora tetrasperma

Raju, NBP, D. D.,  Genetics,  129:25-37. 1991.
It was shown previously that when a chromosomal Spore killer factor is heterozygous in Neurospora species with eight-spored asci, the four sensitive ascospores in each ascus die and the four survivors are all killers. Sk-2K and Sk-3K are nonrecombining haplotypes that segregate ...
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Female house mice avoid fertilization by t haplotype incompatible males in a mate choice experiment

Manser, AK, B.; Lindholm, A. K.,  Journal of Evolutionary Biology,  28:54-64. 2015.
The t haplotype in house mice is a well-known selfish genetic element with detrimental, nonadditive fitness consequences to its carriers: recessive lethal mutations cause t/t homozygotes to perish in utero. Given the severe genetic incompatibility imposed by the t haplotype, we ...
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Field trial of competitive displacement of Aedes-polynesiensis by Aedes-albopictus on a Pacific atoll

L. Rosen, L. E. Rozeboom, W. C. Reeves, J. Saugrain and D. J. Gubler,  American Journal of Tropical Medicine and Hygiene,  25:906-913. 1976.
Prior laboratory studies and field observations suggested that it might be possible to reduce the size of the population of, or eliminate, Aedes polynesiensis by the introduction of Aedes albopictus. The former mosquito is the principal vector of nonperiodic filariasis caused by ...
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First they cloned Dolly the sheep. Now they’re targeting grey squirrels

Leake, J.,  The Times,  2020.
For 150 years they have wreaked havoc on Britain’s woods and wildlife, but the destructive reign of the grey squirrel could soon be over — ended by DNA editing to ensure that all future females are born infertile. Researchers at the Roslin Institute, the genetics laboratory ...
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Fitness consequences of a non-recombining sex-ratio drive chromosome can explain its prevalence in the wild

Dyer, K. A. and D. W. Hall,  Proceedings of the Royal Society B: Biological Sciences,  286:20192529. 2019.
Understanding the pleiotropic consequences of gene drive systems on host fitness is essential to predict their spread through a host population. Here, we study sex-ratio (SR) X-chromosome drive in the fly Drosophila recens, where SR causes the death of Y-bearing sperm in male ...
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Fitness effects of X chromosome drive in the stalk-eyed fly, Cyrtodiopsis dalmanni

Wilkinson, GSJ, P. M.; Kelleher, E. S.; Muscedere, M. L.; Lorsong, A.,  Journal of Evolutionary Biology,  19:1851-1860. 2006.
Sex-ratio (SR) males produce predominantly female progeny because most Y chromosome sperm are rendered nonfunctional. The resulting transmission advantage of X-SR chromosomes should eventually cause population extinction unless segregation distortion is masked by suppressors or ...
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Forcing the Farm

etc group,  etc group,  2018.
This report is being issued as an alert to governments, civil society organisations and grassroots movements. It points to how gene drives, while promoted as a tool for medicine and conservation, will find their real use in food and farming by agribusiness. It calls for a pause ...
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Gene Drive and Thinking Animals

Island Conservation,  ,  2019.
Royden Saah, Island Conservation's GBIRd program manager, recently spoke at the Thinking Animals Summit alongside Leilani Münter, a former professional race car driver and environmental activist. The Genetic Biocontrol of Invasive Rodents partnership (GBIRd) is designed for ...
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Gene drive: progress and prospects

Wedell, N., T. A. R. Price and A. K. Lindholm,  Proceedings of the Royal Society B: Biological Sciences,  286:20192709. 2019.
Gene drive is a naturally occurring phenomenon in which selfish genetic elements manipulate gametogenesis and reproduction to increase their own transmission to the next generation. Currently, there is great excitement about the potential of harnessing such systems to control ...
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Gene-drive-mediated extinction is thwarted by population structure and evolution of sib mating

J. J. Bull, C. H. Remien and S. M. Krone,  Evolution Medicine and Public Health,  2019:66-81. 2019.
Genetic engineering combined with CRISPR technology has developed to the point that gene drives can, in theory, be engineered to cause extinction in countless species. Success of extinction programs now rests on the possibility of resistance evolution, which is largely unknown. ...
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General principles of single-construct chromosomal gene drive

Marshall, JMH, B. A.,  Evolution,  66:2150-2166. 2012.
Gene drive systems are genetic elements capable of spreading into a population even if they confer a fitness cost to their host. We consider a class of drive systems consisting of a chromosomally located, linked cluster of genes, the presence of which renders specific classes of ...
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Genetically engineered mosquitoes out of control

GM Watch,  GM Watch,  2019.
According to a new scientific publication, genetically engineered mosquitoes produced by the biotech company Oxitec (Intrexon) have escaped human control after trials in Brazil. They are now spreading in the environment. The yellow fever mosquitoes (Aedes aegypti) are genetically ...
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Genetically engineering wild mice to combat Lyme disease: An ecological perspective

Snow, A. A.,  BioScience,  69:746-756. 2019.
Genetic engineering of wild populations has been proposed for reducing human diseases by altering pathogens’ hosts. For example, CRISPR- based genome editing may be used to create white-footed mice (Peromyscus leucopus) that are resistant to the Lyme disease ...
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Genetics-driving genes and chromosomes

Charlesworth, B,  Nature,  332:394-395. 1988.
Thereare several genetic and chromosomal systems in which Mendel's first law - the equal probability of transmission of maternal and paternal alternative alleles or homologues - is violated. This phenomenon was named 'meiotic drive' in 1957 by Sandler and Novitski, who drew ...
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Homing endonuclease genes: the rise and fall and rise again of a selfish element

Burt, AK, V.,  Current Opinion in Genetics & Development,  14:609-615. 2004.
Homing endonuclease genes (HEGs) are selfish genetic elements that spread by first cleaving chromosomes that do not contain them and then getting copied across to the broken chromosome as a byproduct of the repair process. The success of this strategy will depend on the ...
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Identifying and detecting potentially adverse ecological outcomes associated with the release of gene-drive modified organisms

Hayes, KRH, G. R.; Dana, G. V.; Foster, S. D.; Ford, J. H.; Thresher, R.; Ickowicz, A.; Peel, D.; Tizard, M.; De Barro, P.; Strive, T.; Dambacher, J. M.,  Journal of Responsible Innovation,  5:S139-S158. 2018.
Synthetic gene drives could provide new solutions to a range of old problems such as controlling vector-borne diseases, agricultural pests and invasive species. In this paper, we outline methods to identify hazards and detect potentially adverse ecological outcomes at the ...
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Identifying knowledge gaps for gene drive research to control invasive animal species: The next CRISPR step

Moro, DB, Margaret; Kennedy, Malcolm; Campbell, Susan; Tizard, Mark,  Global Ecology and Conservation,  13:e00363. 2018.
Invasive animals have been linked to the extinctions of native wildlife, and to significant agricultural financial losses or impacts. Current approaches to control invasive species require ongoing resources and management over large geographic scales, and often result in the ...
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Impact of mosquito gene drive on malaria elimination in a computational model with explicit spatial and temporal dynamics

Eckhoff, PAW, E. A.; Godfray, H. C. J.; Burt, A.,  Proceedings of the National Academy of Sciences of the United States of America,  114:e255-e264. 2017.
The renewed effort to eliminate malaria and permanently remove its tremendous burden highlights questions of what combination of tools would be sufficient in various settings and what new tools need to be developed. Gene drive mosquitoes constitute a promising set of tools, with ...
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Interpopulation spread of a parasitic B chromosome is unlikely through males in the grasshopper Eyprepocnemis plorans

M. I. Manrique-Poyato, J. Cabrero, M. D. López-León, F. Perfectti, R. Gómez and J. P. M. Camacho,  Heredity,  124:197-206. 2019.
The near-neutral model of B chromosome evolution predicts that population invasion is quite fast. To test this prediction, in 1994, we introduced males of the grasshopper Eyprepocnemis plorans from a B-carrying population into a B-lacking population and monitored the evolution of ...
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Invasion and migration of spatially self-limiting gene drives: A comparative analysis

Dhole, S.; Vella, M. R; Lloyd, A. L.; Gould, F.,  Evolutionary Applications,  11:794-808. 2018.
Recent advances in research on gene drives have produced genetic constructs that could theoretically spread a desired gene (payload) into all populations of a species, with a single release in one place. This attribute has advantages, but also comes with risks and ethical ...
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Invasive insects: Management methods explored

McLaughlin, G. M. and P. K. Dearden,  Journal of Insect Science,  19:1-9. 2019.
Invasive insect species can act as a plague across the globe, capable of vast expansion and rapid, proliferate reproduction. The spread of pathogens of serious diseases such as malaria and Zika virus and damages to agricultural crops number some of the afflictions invasive ...
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Large-cage assessment of a transgenic sex-ratio distortion strain on populations of an African malaria vector

Facchinelli, LN, A.; Collins, C.; Menichelli, M.; Persampieri, T.; Bucci, A.; Spaccapelo, R.; Crisanti, A.; Benedict, M.,  Parasites & Vectors,  12:70. 2019.
Novel transgenic mosquito control methods require progressively more realistic evaluation. The goal of this study was to determine the effect of a transgene that causes a male-bias sex ratio on Anopheles gambiae target populations in large insectary cages. Life history ...
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Large-scale selective sweep among Segregation Distorter chromosomes in African populations Drosophila melanogaster

Presgraves, DCG, P. R.; Cherukuri, A.; Lyttle, T. W.,  PLOS Genetics,  5:e1000463. 2009.
Segregation Distorter (SD) is a selfish, coadapted gene complex on chromosome 2 of Drosophila melanogaster that strongly distorts Mendelian transmission; heterozygous SD/SD(+) males sire almost exclusively SD-bearing progeny. Fifty years of genetic, molecular, and theory work ...
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Local dynamics of a fast-evolving sex-ratio system in Drosophila simulans

Bastide, HG, P. R.; Ogereau, D.; Cazemajor, M.; Montchamp-Moreau, C.,  Molecular Ecology,  22:5352-5367. 2013.
By distorting Mendelian transmission to their own advantage, X-linked meiotic drive elements can rapidly spread in natural populations, generating a sex-ratio bias. One expected consequence is the triggering of a co-evolutionary arms race between the sex chromosome that carries ...
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Local selection underlies the geographic distribution of sex-ratio drive in Drosophila neotestacea

Dyer, KA,  Evolution,  66:973-984. 2012.
Selfish genetic elements promote their own transmission to the next generation, often at a cost to the host individual. A sex-ratio (SR) driving X chromosome prevents the maturation of Y-bearing sperm, and as a result is transmitted to 100% of the offspring, all of which are ...
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Making a murderer: The evolutionary framing of hybrid gamete-killers

Sweigart, ALB, Yaniv; Fishman, Lila,  Trends in Genetics,  35:245-252. 2019.
Recent molecular investigations of hybrid incompatibilities have revealed fascinating patterns of genetic interactions that have been interpreted as the remnants of a history of selfish evolution. Instead of framing hybrid incompatibilities in light of genetic conflict, we ...
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Male competition and the evolution of mating and ire-history traits in experimental populations of Aedes aegypti

Qureshi, AA, A.; Hollis, B.; Ponlawat, A.; Cator, L. J.,  Proceedings of the Royal Society B-Biological Sciences,  286:20190591. 2019.
Aedes aegypti is an important disease vector and a major target of reproductive control efforts. We manipulated the opportunity for sexual selection in populations of Ae. aegypti by controlling the number of males competing for a single female. Populations exposed to higher ...
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Male eye span in stalk-eyed flies indicates genetic quality by meiotic drive suppression

Wilkinson, GSP, D. C.; Crymes, L.,  Nature,  391:276-279. 1998.
In some species, females choose mates possessing ornaments that predict offspring survival(1-5). However, sexual selection by female preference for male genetic quality(6-8) remains controversial because conventional genetic mechanisms maintain insufficient variation in male ...
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Meiotic drive alters sperm competitive ability in stalk-eyed flies

Wilkinson, GSF, C. L.,  Proceedings of the Royal Society B-Biological Sciences,  268:2559-2564. 2001.