Keywords: gene drive history

Gene Drives: A scientific case for a complete and perpetual ban

Latham, J,  GeneWatch,  2017.
One of the central issues of our day is how to safely manage the outputs of industrial innovation. Novel products incorporating nanotechnology, biotechnology, rare metals, microwaves, novel chemicals, and more, enter the market on a daily basis. Yet none of these products come ...
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Sterile Insect Techniques, GE mosquitoes and gene drives

Hanson, J,  GeneWatch,  2017.
One of the great temptations in any field is to promote your solution to a problem as the only solution. The recent application of gene drives to sterilize mosquitoes that transmit malaria or viruses like dengue and zika is an example of this tendency to first develop a ...
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Gene drive and collective oversight

Esvelt, K,  GeneWatch,  2017.
As one of the scientists who first described how CRISPR could create gene drive systems capable of altering wild; populations, I am morally responsible for the consequences. I'm writing to you in the hope that the people most; critical of the very idea can help. Bluntly, gene ...
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Concept and history of genetic control

Scott, M. J. and Benedict, M. Q.,  Genetic Control of Malaria and Dengue,  2:31-54. 2016.
Genetic control of insects is an established method, mainly for insects that are important crop and veterinary pests such as medflies and screwworm. Efforts to use the same technologies against insects of medical importance, especially mosquitoes, have had limited success. The ...
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Marcus Rhoades on preferential segregation in maize

Birchler, JA,  Genetics,  203:1489-1490. 2016.
Rhoades was studying a variant form of chromosome 10 with a conspicuous abnormality; it carried extensive heterochromatin at the tip of the long arm. This variant had been found by Albert Longley in indigenous maize varieties from the southwestern United States and provided to ...
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Selfish genetic elements and the gene’s-eye view of evolution

Ågren, JA,  Current Zoology,  62:659-665. 2016.
During the last few decades, we have seen an explosion in the influx of details about the biology of selfish genetic elements. Ever since the early days of the field, the gene’s-eye view of Richard Dawkins, George Williams, and others, has been instrumental to make sense of new ...
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History of the Sterile Insect Technique

Klassen, W. and C. F. Curtis,  Sterile Insect Technique: Principles and Practice in Area-Wide Integrated Pest Managemen,  2005:3-36.. 2005.
During the 1930s and 1940s the idea of releasing insects of pest species to introduce sterility (sterile insect technique or SIT) into wild populations, and thus control them, was independently conceived in three extremely diverse intellectual environments. The key researchers ...
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Marcus Rhoades, preferential segregation and meiotic drive

Birchler, JAD, R. K.; Doebley, J. F.,  Genetics,  164:835-841. 2003.
LONG before microarray biologists coined and promoted the term “discovery science,” maize geneticists were avid practitioners of this mode of investigation. In fact, one might say that for a number of years, the field of maize genetics basically operated as discovery science. ...
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Sander,Larry – The father of meiotic drive

Lindsley, DL,  American Naturalist,  137:283-286. 1991.
The symposium at which the following papers were presented was deprived of what surely would have been a major intellectual contribution by the sudden death of its co-organizer, Larry Sandler, in February 1987. Larry was a leading contributor to the study of segregation ...
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Genetics-driving genes and chromosomes

Charlesworth, B,  Nature,  332:394-395. 1988.
Thereare several genetic and chromosomal systems in which Mendel's first law - the equal probability of transmission of maternal and paternal alternative alleles or homologues - is violated. This phenomenon was named 'meiotic drive' in 1957 by Sandler and Novitski, who drew ...
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Possible use of translocations to fix desirable genes in insect populations.

Curtis, CF,  Nature,  218:368-369. 1968.
Chromosome translocation heterozygotes (T/+) are usually semisterile, but translocation homozygotes (T/T) if viable are usually fully fertile. If such a viable translocation were produced in an insect pest, T/T insects could be reared in captivity and released into the wild, ...
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Applications of genetic technology to mosquito rearing

G. B. Craig,  Bulletin of the World Health Organization,  29:89-97. 1963.
Since the development of insecticide-resistance and the consequent partial failure of the chemical approach to the control of disease vectors, interest in the biological approach has re-awakened. An aspect of the latter approach that is of great current interest is " autocidal ...
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On the role of lethal mutants in the control of populations

R. C. Von Borstel and A. A. Buzzati-Traverso,  Radioisotopes and Radiation in Entomology: Proceedings of a Symposium, Bombay, 5-9 December, 1960,  1962:273-278. 1962.
On the role of lethal. mutants in the control of populations. Population control by release of irradiated males requires that the sperm must be damaged by radiation. The type of damage induced by radiation imposes a restriction on which species may be controlled because if the ...
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Inherited male-producing factor in Aedes aegypti

G. B. Craig, W. A. Hickey and R. C. Vandehey,  Science,  132:1887-1889. 1960.
An inherited factor causes a predominance of males in certain strains and in progeny of single pairs of Aedes aegypti L. This factor appears to be transmitted only by males and is not due to differential mortality, at least in postgametic stages. Mass release of male-producing ...
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Meiotic drive in natural-populations of Drosophila melanogaster 3: Populational implications of the Segregation-Distorter locus

Hiraizumi, YS, L.; Crow, J. E.,  Evolution,  14:433-444. 1960.
If, among the successful gametes frm heterozygotes, one allele is regularly included in more than half, it may increase in frequency even if it has a harmful effect. Unequal gamete production, when attributable to the mechanics of meiosis, has been called meiotic drive (Sandler ...
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Meiotic drive as an evolutionary force

Sandler, LN, E.,  American Naturalist,  91:105-110. 1957.
A heterozygote for alleles A and A' ordinarilly produces gametes carrying each of the alleles with a frequency of 50 per cent. The constancy of allele frequencies from one generation to the nest in natural populations of diploid species depends on this equality, which itself ...
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Screw-worm control through release of sterilized flies

A. H. Baumhover, A. J. Graham, B. A. Bitter, D. E. Hopkins, W. D. New, F. H. Dudley and R. C. Bushland,  Journal of Economic Entomology,  48:462-466. 1955.
Screw-worms, Callitroga hominivorax (Cqrl.), did not exist in the southeastern United States until about 20 years ago, and it is probable that, if the present infestation could be eradicated, the area might be kept free of infestation through inspection of livestock shipments ...
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Possibilities of Insect Control or Eradication Through the Use of Sexually Sterile Males

E. F. Knipling,  Journal of Economic Entomology,  48:459-462. 1955.
The purpose of this paper is to consider the possibility of controlling insects by releasing sexually sterile males among the existing natural population. The principles involved will be described and the potentialities as well as the limitations of the method as we know them at ...
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Eradication of screw-worms through release of sterilized males

R. C. Bushland, A. W. Lindquist and E. F. Knipling,  Science,  122:287-288. 1955.
Although the sterilizing effect of ionizing radiations has been known for years, it is only recently that entomologists have attempted to take advantage of the phenomenon for insect control. Knipling (1) has theorized on the effects of releasing sterilized males among a normal ...
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Preferential segregation in maize

M. M. Rhoades,  Genetics,  27:395-407. 1942.
An abnormal type of chromosome 10, found by Longley in maize from the s.-w. part of the U. S., is preferentially segregated during megasporogenesis. More than 70% of the ovules receive the abnormal chromosome instead of the 50% expected with random segregation. At pachytene the ...
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On the possibility of a new method for the control of insect pests.

A. S. Serebrovskii,  Zoologicheskiĭ zhurnal,  19:618-630 (in Russian). 1940.
ON THE POSSIBILITY OF A NEW METHOD FOR THE CONTROL OF INSECT PESTS. The new principle of insect control consists in disturbing the propagation of the pest population by means of translocations. It is well known that individuals heterozygous for some translocations usually form a ...
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A new sex-ratio abnormality in Drosophila obscura

S. Gershenson,  Genetics,  13:488. 1928.
1. The sex-ratio in the normal lines of Drosophila obscura is very near to the theoretical 1 : 1. 2. Out of 19 females caught in nature, two were heterozygous for a gene which causes strong deviations in the normal sex distribution. 3. The researches made have shown that this ...
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Sur la reproduction des souris anoures

N. Dobrovolskaia-Zavadskaia and N. Kobozieff,  Comptes rendus des séances de la Société de biologie et de ses filiales,  97:116-119. 1927.
Nous ne connaissons que deux lignees de Souris sans queue, celle de Lang (1913), et cell de Duboscq (1922). L’elevange de Lang (lignee des Souris brachyures et anoures du preparateur Alfred Nageli) a donne 199 Souris normales, pour 173 brachyures et 9 anoures. Croisses entre ...
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