Keywords: gene drive natural

Distinct spermiogenic phenotypes underlie sperm elimination in the Segregation Distorter meiotic drive system

M. Herbette, X. L. Wei, C. H. Chang, A. M. Larracuente, B. Loppin and R. Dubruille,  PLOS Genetics,  17:26. 2021.
Here we show that SD/SD+ males of different genotypes but with similarly strong degrees of distortion have distinct spermiogenic phenotypes. In some genotypes, SD+ spermatids fail to fully incorporate protamines after the removal of histones, and degenerate during the ...
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Patterns and Mechanisms of Sex Ratio Distortion in the Collaborative Cross Mouse Mapping Population

B. A. Haines, F. Barradale and B. L. Dumont,  bioRxiv,  2021.
In species with single-locus chromosome-based mechanisms of sex determination, the laws of segregation predict an equal ratio of females to males at birth. Here, we show that departures from this Mendelian expectation are commonplace in the 8-way recombinant inbred Collaborative ...
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Haldane’s duel: intragenomic conflict, selfish Y chromosomes and speciation

S. W. Roy,  Trends in Genetics,  2021.
Haldane?s rule, which states that the heterogametic sex (XY or ZW females) fares more poorly in interspecific hybrids, is generally attributed to absence of one of the two species' X/Z chromosomes. However, Haldane?s rule is also observed in mouse placentas despite paternal X ...
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Nondisjunction and unequal spindle organization accompany the drive of Aegilops speltoides B chromosomes

D. Wu, A. Ruban, J. Fuchs, J. Macas, P. Novák, M. Vaio, Y. Zhou and A. Houben,  New Phytologist,  223:1340-1352. 2021.
B chromosomes (Bs) are supernumerary chromosomes, which are often preferentially inherited. When transmission rates of chromosomes are higher than 0.5, not obeying the Mendelian law of equal segregation, the resulting transmission advantage is collectively referred to as ...
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Researchers report reference genome for maize B chromosome

Chinese Academy of Sciences,  Phys Org,  2021.
Three groups recently reported a reference sequence for the supernumerary B chromosome in maize in a study published online in PNAS. Dr. James Birchler's group from University of Missouri, Dr. Jan Barto's group from Institute of Experimental Botany of the Czech Academy of ...
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First evidence of deviation from Mendelian proportions in a conservation programme

C. E. Grueber, K. A. Farquharson, B. R. Wright, G. P. Wallis, C. J. Hogg and K. Belov,  Molecular Ecology,  13. 2021.
Classic Mendelian inheritance is the bedrock of population genetics and underpins pedigree-based management of animal populations. However, assumptions of Mendelian inheritance might not be upheld in conservation breeding programmes if early viability selection occurs, even when ...
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Mechanistically comparing reproductive manipulations caused by selfish chromosomes and bacterial symbionts

E. Dalla Benetta, O. S. Akbari and P. M. Ferree,  Heredity,  126:707-716. 2021.
Insects naturally harbor a broad range of selfish agents that can manipulate their reproduction and development, often leading to host sex ratio distortion. Such effects directly benefit the spread of the selfish agents. These agents include two broad groups: bacterial symbionts ...
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Selfish chromosomal drive shapes recent centromeric histone evolution in monkeyflowers

F. R. Finseth, T. C. Nelson and L. Fishman,  PLOS Genetics,  17:e1009418. 2021.
Centromeres must mediate faithful chromosomal transmission during cell division and sexual reproduction, but both the DNA and protein components of centromeres diverge rapidly across species. The selfish centromere model argues that this paradoxical diversity results from a ...
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An introgressed gene causes meiotic drive in Neurospora sitophila

J. Svedberg, A. A. Vogan, N. A. Rhoades, D. Sarmarajeewa, D. J. Jacobson, M. Lascoux, T. M. Hammond and H. Johannesson,  Proceedings of the National Academy of Sciences of the United States of America,  118:9. 2021.
Meiotic drive elements cause their own preferential transmission following meiosis. In fungi, this phenomenon takes the shape of spore killing, and in the filamentous ascomycete Neurospora sitophila, the Sk-1 spore killer element is found in many natural populations. In this ...
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Invasion and maintenance of meiotic drivers in populations of ascomycete fungi

I. Martinossi-Allibert, C. Veller, S. L. Ament-Velasquez, A. A. Vogan, C. Rueffler and H. Johannesson,  Evolution,  20. 2021.
Meiotic drivers (MDs) are selfish genetic elements that are able to become overrepresented among the products of meiosis. This transmission advantage makes it possible for them to spread in a population even when they impose fitness costs on their host organisms. Whether an MD ...
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Meiotic drive does not cause condition-dependent reduction of the sexual ornament in stalk-eyed flies

S. R. Finnegan, M. Mondani, K. Fowler and A. Pomiankowski,  Journal of Evolutionary Biology,  11. 2021.
Meiotic drive systems are associated with low-frequency chromosomal inversions. These are expected to accumulate deleterious mutations due to reduced recombination and low effective population size. We test this prediction using the 'sex-ratio' (SR) meiotic drive system of the ...
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Holocentric Chromosomes Probably Do Not Prevent Centromere Drive in Cyperaceae

M. Kratka, J. Smerda, K. Lojdova, P. Bures and F. Zedek,  Frontiers in Plant Science,  12:9. 2021.
In response to these selfish centromeres, the histone protein CenH3, which recruits kinetochore components, adaptively evolves to restore chromosomal parity and counter the detrimental effects of centromere drive. Holocentric chromosomes, whose kinetochores are assembled along ...
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Into the Wild: GMOs head for the forest

L. Sharratt,  Sentinel,  2021.
Genetic engineering is set to leave the farm for the forest. After over twenty years of growing genetically engineered (GE or genetically modified) crop plants in North America, researchers are now proposing to plant GE trees in the forests of eastern US and Canada. This is a ...
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Widespread haploid-biased gene expression enables sperm-level natural selection

K. Bhutani, K. Stansifer, S. Ticau, L. Bojic, A.-C. Villani, J. Slisz, C. M. Cremers, C. Roy, J. Donovan, B. Fiske and R. C. Friedman,  Science,  eabb1723. 2021.
Here, we show that a large class of mammalian genes are not completely shared across these bridges. We term these genes “genoinformative markers” (GIMs) and show that a subset can act as selfish genetic elements that spread alleles unevenly through murine, bovine, and human ...
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Ubiquitous Selfish Toxin-Antidote Elements in Caenorhabditis Species

E. Ben-David, P. Pliota, S. A. Widen, A. Koreshova, T. Lemus-Vergara, P. Verpukhovskiy, S. Mandali, C. Braendle, A. Burga and L. Kruglyak,  Current Biology,  2021.