Keywords: gene drive regulation

Regulation of GM Organisms for Invasive Species Control

H. J. Mitchell and D. Bartsch,  Frontiers in Bioengineering and Biotechnology,  7:1-11. 2020.
Invasive species can cause significant harm to the environment, agriculture, and human health, but there are often very limited tools available to control their populations. Gene drives (GD) have been proposed as a new tool which could be used to control or eliminate such ...
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Beyond Mendelian genetics: Anticipatory biomedical ethics and policy implications for the use of CRISPR together with gene drive in humans.

M. W. Nestor and R. L. Wilson,  Journal of Bioethical Inquiry,  2020:1-12. 2020.
Clustered regularly interspaced short palindromic repeats (CRISPR) genome editing has already reinvented the direction of genetic and stem cell research. For more complex diseases it allows scientists to simultaneously create multiple genetic changes to a single cell. ...
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Technology Factsheet: Gene Drives

J. Lunshof, C. Shachar, R. Edison, A. Jayanti,  Belfer Center for Science and International Affairs,  2020.
Gene drives can be defined as genetic elements that pass from parents to unusually high numbers of their offspring due to biased inheritance (sometimes referred to as the possession of “selfish” genetic elements).1,2 There are different ways of achieving this biased ...
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What risk assessments of genetically modified organisms can learn from institutional analyses of public health risks

Rajan, S. R. and D. K. Letourneau,  Journal of Biomedicine and Biotechnology,  2012:8. 2019.
The risks of genetically modified organisms (GMOs) are evaluated traditionally by combining hazard identification and exposure estimates to provide decision support for regulatory agencies. We question the utility of the classical risk paradigm and discuss its evolution in GMO ...
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Gene Drive Technologies: Powerful and destructive

SWISSAID,  ,  2019.
Gene drive organisms can put our environment, food and health in danger: this is made clear by the video from SWISSAID, the Alliance for GMO-free Switzerland and the ETC Group.
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Gene Drives: Experience with gene drive systems that may inform an environmental risk assessment

Rüdelsheim, PKJS, G.,  COGEM,  2019.
Gene drives are genetic mechanisms that allow for a trait to be propagated throughout a population; beyond Mendelian inheritance. Active in sexually-reproducing species, they are powerful tools to “drive”; a gene, i.e. increase its frequency, independent of external selection ...
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Gene drive gone wild: exploring deliberative possibilities by developing One Health ethics

Capps, B,  Law, Innovation and Technology,  11:231-256. 2019.
Gene editing may be used to engineer organisms that are better or worse adapted to survival. Coupled with gene drives ? molecular genetic strategies that perpetuate specific phenotypes in a target species ? it would now be possible to edit wild animal populations that impact on ...
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The EU regulatory framework on genetically modified organisms (GMOs)

Bruetschy, C,  Transgenic Research,  28:169-174. 2019.
The European Union (EU) legislation on genetically modified organisms (GMOs) aims to ensure a high level of protection for human, animal and environmental health and a well-functioning EU internal market. The framework regulates the release of GMOs into the environment and their ...
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A Question of Consent: Exterminator Mosquitoes in Burkina Faso

ETC group,  ,  2019.
Target Malaria’s planned release of GMO mosquitos is step toward release of gene drive mosquitoes, a high-risk technology aimed at the elimination of entire species. Hundreds of organizations have demanded a moratorium on the use of this technology outside of ...
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Unintended consequences of 21st century technology for agricultural pest management

Young, SL,  EMBO reports,  18:1478-1478. 2017.
Comment on Agricultural pest control with CRISPR-based gene drive: time for public debate by Courtier-Orgogozo et al.
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CRISPR-based gene drive in agriculture will face technical and governance challenges

Gutzmann, NE, Johanna E.; Barnes, Jessica Cavin; Baltzegar, Jennifer; Jones, Michael S.; Sudweeks, Jayce,  EMBO reports,  18:1479-1480. 2017.
Comment on "Agricultural pest control with CRISPR-based gene drive: time for public debate" by Courtier-Orgogozo et al.
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Engineering the wild: Gene drives and intergenerational equity

J. Kuzma and L. Rawls,  Jurimetrics,  56:279-296. 2016.
New genetic engineering methods are allowing scientists to insert genes into organisms that have the potential to spread themselves throughout natural populations upon the release of individuals carrying those genes. Gene drive technology is being researched and developed for ...
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Deployment of innovative genetic vector control strategies: progress on regulatory and biosafety aspects, capacity building and development of best-practice guidance

Beech, CV, S.S.; Quinlan, M.M.; Capurro, Margareth L.; Alphey, L.; Bayard, V.; Bouare, M.; McLeod, M.C.; Kittayapong, P.; Lavery, J.; Lim, L.H.; Marrelli, M.T.; Nagaraju, J.; Ombongi, K.; Othman, R.Y.; Pillai, V.; Ramsey, J.; Reuben, R.; Rose, R.I.; Tyagi, B.K.; Mumford, J.,  AsPac J. Mol. Biol. Biotechnol.,  17:75-85. 2009.
In the ongoing fight against vectors of human diseases, disease endemic countries (DECs) may soon benefit from innovative control strategies involving modified insect vectors. For instance, three promising methods (viz. RIDL® [Release of Insects with a Dominant Lethal], ...
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