Keywords: gene drive reviews

The Buzz About Genetically Modified Mosquitoes – a podcast

The Scientist Creative Services Team,  The Scientist,  podcast. 2020.
Mosquito-borne diseases afflict a large portion of the world. In this month’s episode, we consider genetic methods to eradicate diseases such as Zika fever, Dengue fever, and malaria. We spoke with Omar Akbari, professor of Cell and Developmental Biology at the University of ...
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Technology Factsheet: Gene Drives

J. Lunshof, C. Shachar, R. Edison, A. Jayanti,  Belfer Center for Science and International Affairs,  2020.
Gene drives can be defined as genetic elements that pass from parents to unusually high numbers of their offspring due to biased inheritance (sometimes referred to as the possession of “selfish” genetic elements).1,2 There are different ways of achieving this biased ...
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Targeting female reproduction in insects with biorational insecticides for pest management: a critical review with suggestions for future research

Smagghe, GZ, M.; Retnakaran, A.,  Current Opinion in Insect Science,  31:65-69. 2019.
Of the different approaches to pest control, use of juvenile hormone analogs (e.g. methoprene), molting hormone (20-hydroxyecdysone) analogs (e.g. tebufenozide) and chitin synthesis inhibitors (e.g. diflubenzuron) has dominated this field. Since they adversely interfere with the ...
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Gene drive research: Why it matters

The Royal Society,  Royal Society Statement,  2018.
Gene drives are systems that bias the inheritance of a particular DNA sequence. Many such systems occur naturally and scientists are now investigating the potential to develop new ones using synthetic biology techniques. Synthetic gene drives are being developed for a range of ...
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Advancing a new toolkit for conservation: From science to policy

Novak, BJM, T.; Phelan, R.,  CRISPR Journal,  1:11-15. 2018.
Climate change and non-native wildlife diseases are exacerbating persistent challenges to biodiversity such as habitat destruction, invasive species and over-harvesting. With these increasing threats there is a pressing need to expand the conservationists' toolbox. CRISPR-Cas9 ...
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Gene drive: Evolved and synthetic

Burt, AC, Andrea,  ACS Chemical Biology,  13:343-346. 2018.
Drive is a process of accelerated inheritance from one generation to the next that allows some genes to spread rapidly through populations even if they do not contribute to—or indeed even if they detract from—organismal survival and reproduction. Genetic elements that can ...
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The promise and peril of CRISPR gene drives

Zentner, GEW, Michael J. C.,  Bioessays,  39:1-9. 2017.
Gene drives are selfish genetic elements that use a variety of mechanisms to ensure they are transmitted to subsequent generations at greater than expected frequencies. Synthetic gene drives based on the clustered regularly interspersed palindromic repeats (CRISPR) genome editing ...
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Cheating evolution: engineering gene drives to manipulate the fate of wild populations

Champer, JB, A.; Akbari, O. S.,  Nature Reviews Genetics,  17:146-159. 2016.
Engineered gene drives - the process of stimulating the biased inheritance of specific genes - have the potential to enable the spread of desirable genes throughout wild populations or to suppress harmful species, and may be particularly useful for the control of vector-borne ...
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Sex chromosome drive

Helleu, QG, P. R.; Montchamp-Moreau, C.,  Cold Spring Harbor Perspectives in Biology,  7:a017616. 2015.
Sex chromosome drivers are selfish elements that subvert Mendel's first law of segregation and therefore are over represented among the products of meiosis. The sex-biased progeny produced then fuels an extended genetic conflict between the driver and the rest of the genome. Many ...
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The next generation of rodent eradications: Innovative technologies and tools to improve species specificity and increase their feasibility on islands

Campbell, KJB, J.; Eason, C. T.; Glen, A. S.; Godwin, J.; Gould, F.; Holmes, N. D.; Howald, G. R.; Madden, F. M.; Ponder, J. B.; Threadgill, D. W.; Wegmann, A. S.; Baxter, G. S.,  Biological Conservation,  185:47-58. 2015.
Rodents remain one of the most widespread and damaging invasive alien species on islands globally. The current toolbox for insular rodent eradications is reliant on the application of sufficient anticoagulant toxicant into every potential rodent territory across an island. ...
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Heritable strategies for controlling insect vectors of disease

Burt, A,  Philosophical Transactions of the Royal Society B-Biological Sciences,  369:20130432. 2014.
Mosquito-borne diseases are causing a substantial burden of mortality, morbidity and economic loss in many parts of the world, despite current control efforts, and new complementary approaches to controlling these diseases are needed. One promising class of new interventions ...
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Drive and sperm: The evolution and genetics of male meiotic drive

Presgraves, D,  Sperm Biology: an Evolutionary Perspective,  12:471-506. 2009.
Some selfish genetic elements in eukaryotic genomes have been harnessed to perform essential functions for their hosts, whereas others have gained transmission advantages at the expense of their hosts. Meiotic drive elements are particularly dramatic examples of the latter. ...
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Broadening the application of evolutionarily based genetic pest management

Gould, F,  Evolution,  62:500-510. 2008.
Insect- and tick-vectored diseases such as malaria, dengue fever, and Lyme disease cause human suffering, and current approaches for prevention are not adequate. Invasive plants and animals such as Scotch broom, zebra mussels, and gypsy moths continue to cause environmental ...
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Meiotic drive – Bickering genes shape evolution – Not all genes follow the rules of inheritance; now researchers are discovering how organisms adapt to the troublemakers

Pennisi, E,  Science,  301:1837-1839. 2003.
Reproduction is supposed to be an equal opportunity event. Consider humans: In developing sperm, the sex chromosomes sort 50:50 such that half the sperm carry the male-defining Y chromosome and the rest sport an X. Only the randomness of fertilization leads to families of nine ...
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Segregation distorters

Lyttle, TW,  Annual Review of Genetics,  25:511-557. 1991.
Segregation distorters are genetic elements that exhibit the phenomenon of meiotic drive; that is, the mechanics of the meiotic divisions cause one member of a pair of heterozygous alleles or heteromorphic chromosomes to be transmitted to progeny in excess of the expected ...
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The genetics and evolutionary biology of meiotic drive: Preface

Lyttle, TW,  American Naturalist,  137:281-282. 1991.
More than 30 years have passed since the concept and the term meiotic drive were introduced by Sandler and Novitski. Many years have also passed since the preceding conference, which embraced both segregation distortion in Drosophial and transmission-distortion in the mouse, and ...
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Genetics-driving genes and chromosomes

Charlesworth, B,  Nature,  332:394-395. 1988.
Thereare several genetic and chromosomal systems in which Mendel's first law - the equal probability of transmission of maternal and paternal alternative alleles or homologues - is violated. This phenomenon was named 'meiotic drive' in 1957 by Sandler and Novitski, who drew ...
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Methods for replacement of malaria vector populations

Curtis, CFG, P. M.,  American Journal of Tropical Medicine and Hygiene,  91:43-48. 1988.
The prospects are reviewed of replacement of malaria vector populations by harmless mosquito populations by means of: (i) ecologically competitive non-vector species; (ii) natural selection due to the harmfulness of being infected; (iii) selection for insecticide resistance ...
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Mechanisms of meiotic drive

Zimmering, SS, L.; Nicoletti, B.,  Annual Review of Genetics,  4:409-436. 1970.
Meiotic drive has been defined by Sandler & Novitski (157) as any alteration of the normal process of meiosis with the consequence that a heterozygote for two genetic alternatives produces an effective gametic pool with an excess of one type; such a pattern of behavior ...
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