Keywords: gonotaxis

Centromere drive: model systems and experimental progress

D. Dudka and M. A. Lampson,  Chromosome Research,  2022.
Centromeres connect chromosomes and spindle microtubules to ensure faithful chromosome segregation. Paradoxically, despite this conserved function, centromeric DNA evolves rapidly and centromeric proteins show signatures of positive selection. The centromere drive hypothesis ...
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Tubulin post-translational modifications in meiosis

T. Akera,  Seminars in Cell & Developmental Biology,  2021.
Haploid gametes are produced from diploid parents through meiosis, a process inherent to all sexually reproducing eukaryotes. Faithful chromosome segregation in meiosis is essential for reproductive success, although it is less clear how the meiotic spindle achieves this compared ...
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Unravelling the mystery of female meiotic drive: where we are

F. E. Clark and T. Akera,  Open Biol,  11:210074. 2021.
Female meiotic drive is the phenomenon where a selfish genetic element alters chromosome segregation during female meiosis to segregate to the egg and transmit to the next generation more frequently than Mendelian expectation. While several examples of female meiotic drive have ...
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Meiotic drive

A. N. Srinivasa and S. E. Zanders,  Current Biology,  30:R627-R629. 2020.
What is meiotic drive? Diploid organisms, like you, have two copies of each autosomal chromosome, one from each parent. Sometimes organisms are heterozygous at a given region, meaning they carry different copies (or alleles) of the DNA sequence on the two homologous chromosomes. ...
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Strategies for Achieving Gene Drive – Gonotaxis

GeneConvene Global Collaborative,  GeneConvene Global Collaborative,  2020.
This video explains how there are three strategies for achieving gene drive and focuses on one, gonotaxis.  Gonotaxis is explained and illustrated.  While well-described in various plants and animals, gene drive researchers and technology developers have not recreated gonotaxis ...
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How selfish DNA hijacks its way into egg cells

Science Magazine,  Science,  2017.
This video was produced by Science magazine and explains and illustrates how gonotaxis or the asymmetrical allocation of chromosomes to developing female gametes occurs in mice. This video reflects an understanding of this process based on the publication by Akera et al (2017).
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Spindle asymmetry drives non-Mendelian chromosome segregation

T. Akera, L. Chmátal, E. Trimm, K. Yang, C. Aonbangkhen, D. M. Chenoweth, C. Janke, R. M. Schultz and M. A. Lampson,  Science,  358:668. 2017.
Genetic elements compete for transmission through meiosis, when haploid gametes are created from a diploid parent. Selfish elements can enhance their transmission through a process known as meiotic drive. In female meiosis, selfish elements drive by preferentially attaching to ...
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Polar bodies–more a lack of understanding than a lack of respect

S. Schmerler and G. M. Wessel,  Molecular Reproduction and Development,  78:3-8. 2010.
Polar bodies are as diverse as the organisms that produce them. Although in many animals these cells often die following meiotic maturation of the oocyte, in other organisms they are an essential and diverse part of embryonic development. Here we highlight some of this diversity ...
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