A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage populationJ. Champer, E. Yang, E. Lee, J. Liu, A. G. Clark and P. W. Messer, Proceedings of the National Academy of Sciences, 202004373. 2020.
Here, we present a CRISPR homing drive that was able to successfully spread to all individuals in a laboratory cage study in Drosophila melanogaster without any apparent evolution of resistance.
Keywords: cleave and rescue, gene drive synthetic, haploinsufficient, population modification, resistance, synthetic homing drive