Keywords: haploinsufficient
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A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage populationJ. Champer, E. Yang, E. Lee, J. Liu, A. G. Clark and P. W. Messer, Proceedings of the National Academy of Sciences, 202004373. 2020.
Here, we present a CRISPR homing drive that was able to successfully spread to all individuals in a laboratory cage study in Drosophila melanogaster without any apparent evolution of resistance. |
