Keywords: Herpes
|
Targeting Conserved Sequences Circumvents the Evolution of Resistance in a Viral Gene Drive against Human CytomegalovirusM. Walter, R. Perrone, E. Verdin and F. Goodrum, Journal of Virology, 95:e00802-21. 2021.
Gene drives are genetic systems designed to efficiently spread a modification through a population. They have been designed almost exclusively in eukaryotic species, especially in insects. We recently developed a CRISPR-based gene drive system in herpesviruses that relies on ... |
|
|
Targeting conserved sequences circumvents the evolution of resistance in a viral gene drive against human cytomegalovirusM. Walter, R. Perrone and E. Verdin, Journal of virology, 2021.
Here, we analyze in cell culture experiments the evolution of resistance in a viral gene drive against human cytomegalovirus. We report that, after an initial invasion of the wildtype population, a drive-resistant population is positively selected over time and outcompetes gene ... |
|
Targeting evolutionary conserved sequences circumvents the evolution of resistance in a viral gene drive against human cytomegalovirusM. Walter, R. Perrone and E. Verdin, bioRxiv, 2021.01.08.425902. 2021.
Here, we analyze in cell culture experiments the evolution of resistance in a gene drive against human cytomegalovirus. We report that after an initial invasion of the wildtype population, a drive-resistant population is positively selected over time and outcompetes gene drive ... |
|
Viral gene drive in herpesvirusesM. Walter and E. Verdin, Nature Communications, 11:4884. 2020.
Here, we report on a gene drive system that allows the spread of an engineered trait in populations of DNA viruses and, in particular, herpesviruses. |
