Keywords: Humans
|
Guerrilla eugenics: gene drives in heritable human genome editingA. D. Cutter, J Med Ethics, 2023.
CRISPR-Cas9 genome editing can and has altered human genomes, bringing bioethical debates about this capability to the forefront of philosophical and policy considerations. Here, I consider the underexplored implications of CRISPR-Cas9 gene drives for heritable human genome ... |
|
Meiotic drive in chronic lymphocytic leukemia compared with other malignant blood disordersV. Jonsson, H. Awan, N. D. Jones, T. B. Johannesen, K. Thogersen, B. A. Steig, G. Andorsdottir and G. E. Tjonnfjord, Scientific Reports, 12:6138. 2022.
The heredity of the malignant blood disorders, leukemias, lymphomas and myeloma, has so far been largely unknown. The present study comprises genealogical investigations of one hundred and twelve Scandinavian families with unrelated parents and two or more cases of malignant ... |
|
Ethics of Genome EditingEuropean Group on Ethics, European Group on Ethics in Science and New Technologies, 2021.
This Opinion addresses the profound ethical questions raised and revived by them. It analyses various domains of application, from human health to animal experimentation, from livestock breeding to crop variety and to gene drives. With its wide view across areas, it identifies ... |
|
Beyond Mendelian genetics: Anticipatory biomedical ethics and policy implications for the use of CRISPR together with gene drive in humans.M. W. Nestor and R. L. Wilson, Journal of Bioethical Inquiry, 2020:1-12. 2020.
Clustered regularly interspaced short palindromic repeats (CRISPR) genome editing has already reinvented the direction of genetic and stem cell research. For more complex diseases it allows scientists to simultaneously create multiple genetic changes to a single cell. ... |
|
Polar bodies–more a lack of understanding than a lack of respectS. Schmerler and G. M. Wessel, Molecular Reproduction and Development, 78:3-8. 2010.
Polar bodies are as diverse as the organisms that produce them. Although in many animals these cells often die following meiotic maturation of the oocyte, in other organisms they are an essential and diverse part of embryonic development. Here we highlight some of this diversity ... |
|
Exploring the public understanding of basic genetic conceptsLanie, ADJ, Toby Epstein; Sheldon, Jane P.; Kardia, Sharon L. R.; Anderson, Elizabeth S.; Feldbaum, Merle; Petty, Elizabeth M., Journal of Genetic Counseling, 13:305-320. 2004.
It is predicted that the rapid acquisition of new genetic knowledge and related applications during the next decade will have significant implications for virtually all members of society. Currently, most people get exposed to information about genes and genetics only through ... |
