Keywords: insecticide resistance
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Could Crispr Flip the Switch on Insects’ Resistance to Pesticides?E. Mullin, WIRED, 2022.
WHILE THE COVID-19 pandemic raged across the world in 2020, another disease was quietly infecting more than 220 million people on the continent of Africa: malaria. That year, the disease led to more than 600,000 deaths, most of them children. Caused by the parasite Plasmodium, ... |
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Genetic strategy reverses insecticide resistanceM. Aguilera, Phys Org, 2022.
University of California San Diego biologists have now developed a method that reverses insecticide resistance using CRISPR/Cas9 technology. As described in Nature Communications, researchers Bhagyashree Kaduskar, Raja Kushwah and Professor Ethan Bier with the Tata Institute for ... |
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Reversing insecticide resistance with allelic-drive in Drosophila melanogasterB. Kaduskar, R. B. S. Kushwah, A. Auradkar, A. Guichard, M. Li, J. B. Bennett, A. H. F. Julio, J. M. Marshall, C. Montell and E. Bier, Nature Communications, 13:291. 2022.
A recurring target-site mutation identified in various pests and disease vectors alters the voltage gated sodium channel (vgsc) gene (often referred to as knockdown resistance or kdr) to confer resistance to commonly used insecticides, pyrethroids and DDT. The ubiquity of kdr ... |
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Improving mosquito control strategies with population genomicsT. L. Schmidt, N. M. Endersby-Harshman and A. A. Hoffmann, Trends in Parasitology, 37:907-921. 2021.
Mosquito control strategies increasingly apply knowledge from population genomics research. This review highlights recent applications to three research domains: mosquito invasions, insecticide resistance evolution, and rear and release programs. Current research trends follow ... |
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Mosquito-Borne Diseases Emergence/Resurgence and How to Effectively Control It BiologicallyH. Dahmana and O. Mediannikov, Pathogens, 9:26. 2020.
Deadly pathogens and parasites are transmitted by vectors and the mosquito is considered the most threatening vector in public health, transmitting these pathogens to humans and animals. We are currently witnessing the emergence/resurgence in new regions/populations of the most ... |
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MGDrivE: A modular simulation framework for the spread of gene drives through spatially-explicit mosquito populationsSánchez C, HMW, Sean L.; Bennett, Jared B.; Marshall, John M., Methods in Ecology and Evolution, 10:1-24. 2019.
Malaria, dengue, Zika, and other mosquito-borne diseases continue to pose a major global health burden through much of the world, despite the widespread distribution of insecticide-based tools and antimalarial drugs. The advent of CRISPR/Cas9-based gene editing and its ... |
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Global report on insecticide resistance in malaria vectors: 2010-2016.WHO, World Health Organization, 2018.
Insecticide-based vector control is a cornerstone in the fight against malaria. Selection of vector-control interventions should take into account the resistance status of local mosquito vectors along with other factors associated with intervention deployment and use such as ... |
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Current vector control challenges in the fight against malariaG. Benelli and J. C. Beier, Acta Tropica, 174:91-96. 2017.
The majority of National Malaria Control Programs in Africa still rely on indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs). These methods reduce malaria incidence but generally have little impact on malaria prevalence. In addition to outdoor transmission, ... |
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The Impact of Pyrethroid Resistance on the Efficacy of Insecticide-Treated Bed Nets against African Anopheline Mosquitoes: Systematic Review and Meta-Analysis.C. Strode, S. Donegan, P. Garner, A. A. Enayati and J. Hemingway, PLOS Medicine, 11:e1001619. 2014.
This meta-analysis found that ITNs are more effective than UTNs regardless of resistance. There appears to be a relationship between resistance and the RD for mosquito mortality in laboratory and field studies. However, the substantive heterogeneity in the studies' results and ... |
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Modelling the spatial spread of a homing endonuclease gene in a mosquito populationNorth, AB, A.; Godfray, H. C. J., Journal of Applied Ecology, 50:1216-1225. 2013.
Homing endonuclease genes (HEGs) exist naturally in many single-celled organisms and can show extremely strong genetic drive allowing them to spread through populations into which they are introduced. They are being investigated as tools to manipulate the populations of important ... |
