Keywords: introgression

Split drive killer-rescue provides a novel threshold-dependent gene drive M. P. Edgington, T. Harvey-Samuel and L. Alphey,  Scientific Reports,  10:13. 2020. We show that although end-joining repair mechanisms may cause the system to break down, under certain conditions, it should persist over time scales relevant for genetic control programs. The potential of such a system to provide localised population suppression via sex ratio ... Keywords: Aedes aegypti, CRISPR-Cas9, engineered underdominance, gene drive synthetic, introgression, modelling, mosquito, populations, resistance

Keywords: introgression

Split drive killer-rescue provides a novel threshold-dependent gene drive M. P. Edgington, T. Harvey-Samuel and L. Alphey,  Scientific Reports,  10:13. 2020. We show that although end-joining repair mechanisms may cause the system to break down, under certain conditions, it should persist over time scales relevant for genetic control programs. The potential of such a system to provide localised population suppression via sex ratio ... Keywords: Aedes aegypti, CRISPR-Cas9, engineered underdominance, gene drive synthetic, introgression, modelling, mosquito, populations, resistance