Keywords: M factor
Nix alone is sufficient to convert female Aedes aegypti into fertile males and myo-sex is needed for male flightA. Aryan, M. A. E. Anderson, J. K. Biedler, Y. M. Qi, J. M. Overcash, A. N. Naumenko, M. V. Sharakhova, C. H. Mao, Z. N. Adelman and Z. J. Tu, Proceedings of the National Academy of Sciences of the United States of America, 117:17702-17709. 2020.
Here, we report the generation of multiple transgenic lines that express Nix under the control of its own promoter. Genetic and molecular analyses of these lines provided insights unattainable from previous transient experiments. We show that the Nix transgene alone, in the ...
Keywords: Aedes, aegypti, drosophila, gene drive synthetic, genetic biocontrol, infectious-diseases, M factor, mosquito, Mutagenesis, sex determination, SIT, sterile insect technique, y-chromosome
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National Institutes of Health