Pest demography critically determines the viability of synthetic gene drives for population controlK. E. Wilkins, T. A. A. Prowse, P. Cassey, P. Q. Thomas and J. V. Ross, Mathematical Biosciences, 305:160-169. 2018.
Synthetic gene drives offer a novel solution for the control of invasive alien species. CRISPR-based gene drives can positively bias their own inheritance, and comprise a DNA sequence that is replicated by homologous recombination. Since gene drives can be positioned to silence ...
Keywords: CRISPR, Eradication, Evolution, extinction, Gene drive, gene drive synthetic, genetic biocontrol, house mice, invasive, manipulate, maternal nutrition, Mating system, models, Pest eradication, Population modelling, resistance, sex-ratio, species, Synthetic biology, Trojan-Y Chromosome, wild
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