Keywords: Mathematical model

MGDrivE: A modular simulation framework for the spread of gene drives through spatially-explicit mosquito populations

Sánchez C, HMW, Sean L.; Bennett, Jared B.; Marshall, John M.,  Methods in Ecology and Evolution,  10:1-24. 2019.
Malaria, dengue, Zika, and other mosquito-borne diseases continue to pose a major global health burden through much of the world, despite the widespread distribution of insecticide-based tools and antimalarial drugs. The advent of CRISPR/Cas9-based gene editing and its ...
Keywords: , , , , , , ,

Spatial structure undermines parasite suppression by gene drive cargo

Bull, JJR, Christopher H.; Gomulkiewicz, Richard; Krone, Stephen M.,  PeerJ,  7:e7921. 2019.
Gene drives may be used in two ways to curtail vectored diseases. Both involve engineering the drive to spread in the vector population. One approach uses the drive to directly depress vector numbers, possibly to extinction. The other approach leaves intact the vector population ...
Keywords: , , , , , , ,

Competition at the Mouse t Complex: Rare Alleles Are Inherently Favored

van Boven, MW, Franz J.,  Theoretical Population Biology,  60:343-358. 2001.
We investigate the competition between alleles at a segregation distorter locus. The focus is on the invasion prospects of rare mutant distorter alleles in a population in which a wildtype and a resident distorter allele are present. The parameters are chosen to reflect the ...
Keywords: , , , , , , ,