Keywords: meiosis

Mixed knobs in corn cobs

P. Lamelza and M. A. Lampson,  Genes and Development,  34:1110-1112. 2020.
In this issue of Genes & Development, Swentowsky and colleagues (pp. 1239-1251) show that two types of knobs, those composed of 180-bp and TR1 sequences, recruit their own novel and divergent kinesin-14 family members to form neocentromeres.
Keywords: , , , , , , , , , , , , , , , , , , , , , , ,

Distinct kinesin motors drive two types of maize neocentromeres

K. W. Swentowsky, J. I. Gent, E. G. Lowry, V. Schubert, X. Ran, K. F. Tseng, A. E. Harkess, W. H. Qiu and R. K. Dawe,  Genes and Development,  34:1239-1251. 2020.
Here we describe a second kinesin-14 gene, TR-1 kinesin (Trkin), that is required to mobilize neocentromeres made up of the minor tandem repeat TR-1.
Keywords: , , , , , , , , , , , , , , , , , , , , , , ,

Atypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic drivers

M. A. Bravo Núñez, I. M. Sabbarini, L. E. Eide, R. L. Unckless and S. E. Zanders,  eLife,  9:e57936. 2020.
Here, we demonstrate that in scenarios analogous to outcrossing, wtf drivers generate a fitness landscape in which atypical spores, such as aneuploids and diploids, are advantageous. In this context, wtf drivers can decrease the fitness costs of mutations that disrupt meiotic ...
Keywords: , , , , , , , , , , , , , , , , , , , , , , ,

Gene Drive – The Concept Explained

GeneConvene Global Collaborative,  GeneConvene Global Collaborative,  2020.
This short video is intended to serve as a short tutorial that explains the general idea of 'drive' or 'gene drive' in the context of genetics.  It provides the viewer with a basic understanding of the key genetic processes underlying the patterns of inheritance with which most ...
Keywords: , , , , , , , , , , , , , , , , , , , , , , ,

Meiotic drive shapes rates of karyotype evolution in mammals

Blackmon, H., J. Justison, I. Mayrose and E. E. Goldberg,  Evolution,  73:511-523. 2019.
Chromosome number is perhaps the most basic characteristic of a genome, yet generalizations that can explain the evolution of this trait across large clades have remained elusive. Using karyotype data from over 1000 mammals, we developed and applied a phylogenetic model of ...
Keywords: , , , , , , , , , , , , , , , , , , , , , , ,

Genetic villains: Killer meiotic drivers

Bravo Núñez, MAN, Nicole L.; Zanders, Sarah E.,  Trends in Genetics,  34:424-433. 2018.
Unbiased allele transmission into progeny is a fundamental genetic concept canonized as Mendel’s Law of Segregation. Not all alleles, however, abide by the law. Killer meiotic drivers are ultra-selfish DNA sequences that are transmitted into more than half (sometimes all) of ...
Keywords: , , , , , , , , , , , , , , , , , , , , , , ,

Veni, vidi, vici: the success of wtf meiotic drivers in fission yeast

López Hernández, JFZ, Sarah E.,  Yeast,  35:447-453. 2018.
Meiotic drivers are selfish DNA loci that can bias their own transmission into gametes. Owing to their transmission advantages, meiotic drivers can spread in populations even if the drivers or linked variants decrease organismal fitness. Meiotic drive was first formally described ...
Keywords: , , , , , , , , , , , , , , , , , , , , , , ,

How selfish DNA hijacks its way into egg cells

Science Magazine,  Science,  2017.
This video was produced by Science magazine and explains and illustrates how gonotaxis or the asymmetrical allocation of chromosomes to developing female gametes occurs in mice. This video reflects an understanding of this process based on the publication by Akera et al (2017).
Keywords: , , , , , , , , , , , , , , , , , , , , , , ,

Genetic conflicts: the usual suspects and beyond

McLaughlin, RNM, H. S.,  Journal of Experimental Biology,  220:6-17. 2017.
Selfishness is pervasive and manifests at all scales of biology, from societies, to individuals, to genetic elements within a genome. The relentless struggle to seek evolutionary advantages drives perpetual cycles of adaptation and counter-adaptation, commonly referred to as Red ...
Keywords: , , , , , , , , , , , , , , , , , , , , , , ,