Keywords: meiotic drive

Natural and Engineered Sex Ratio Distortion in Insects

A. Compton and Z. Tu,  Frontiers in Ecology and Evolution,  10. 2022.
Insects have evolved highly diverse genetic sex-determination mechanisms and a relatively balanced male to female sex ratio is generally expected. However, selection may shift the optimal sex ratio while meiotic drive and endosymbiont manipulation can result in sex ratio ...
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Meiotic behavior, transmission and active genes of B chromosomes in the cichlid Astatotilapia latifasciata: new clues about nature, evolution and maintenance of accessory elements

A. L. Cardoso, N. B. Venturelli, I. da Cruz, F. M. de Sá Patroni, D. de Moraes, R. A. de Oliveira, R. Benavente and C. Martins,  Molecular Genetics and Genomics,  2022.
Supernumerary B chromosomes (Bs) are dispensable genetic elements widespread in eukaryotes and are poorly understood mainly in relation to mechanisms of maintenance and transmission. The cichlid Astatotilapia latifasciata can harbor Bs in a range of 0 (named B -) and 1-2 (named ...
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Selective targeting of biting females to control mosquito-borne infectious diseases

B. B. Kojin, A. Compton, Z. N. Adelman and Z. Tu,  Trends in Parasitology,  2022.
Mosquitoes are vectors for a number of infectious diseases. Only females feed on blood to provision for their embryos and, in doing so, transmit pathogens to the associated vertebrate hosts. Therefore, sex is an important phenotype in the context of genetic control programs, both ...
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Iterative evolution of supergene-based social polymorphism in ants

T. Kay, Q. Helleu and L. Keller,  Philos Trans R Soc Lond B Biol Sci,  377:20210196. 2022.
Species commonly exhibit alternative morphs, with individual fate being determined during development by either genetic factors, environmental cues or a combination thereof. Ants offer an interesting case study because many species are polymorphic in their social structure. Some ...
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Supergene potential of a selfish centromere

F. Finseth, K. Brown, A. Demaree and L. Fishman,  Philos Trans R Soc Lond B Biol Sci,  377:20210208. 2022.
Selfishly evolving centromeres bias their transmission by exploiting the asymmetry of female meiosis and preferentially segregating to the egg. Such female meiotic drive systems have the potential to be supergenes, with multiple linked loci contributing to drive costs or ...
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Mendel’s First Law: partisan interests and the parliament of genes

C. Veller,  Heredity,  2022.
Mendel’s First Law requires explanation because of the possibility of ‘meiotic drivers’, genes that distort fair segregation for selfish gain. The suppression of drive, and the restoration of fair segregation, is often attributed to genes at loci unlinked to the drive ...
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Non-Mendelian segregation and transmission drive of B chromosomes

J. P. M. Camacho,  Chromosome Research,  2022.
Selfish genetic elements (SGE) get a transmission advantage (drive) thanks to their non-Mendelian inheritance. Here I identify eight steps during the reproductive cycle that can be subverted by SGEs to thrive in natural populations. Even though only three steps occur during ...
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A meiotic driver alters sperm form and function in house mice: a possible example of spite

L. Winkler and A. K. Lindholm,  Chromosome Research,  2022.
The ability to subvert independent assortment of chromosomes is found in many meiotic drivers, such as the t haplotype in house mice Mus musculus, in which the t-bearing chromosomal homolog is preferentially transmitted to offspring. This is explained by a poison-antidote system, ...
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The Cif proteins from Wolbachia prophage WO modify sperm genome integrity to establish cytoplasmic incompatibility

R. Kaur, B. A. Leigh, I. T. Ritchie and S. R. Bordenstein,  PLOS Biology,  20:e3001584. 2022.
In Drosophila melanogaster, germline expression of the Wolbachia proteins CifA and CifB causes cytoplasmic incompatibility, but how this impairs male reproduction remains unclear. This study shows how Cif proteins encoded by the endosymbiont prophage invade the fly’s gametic ...
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The fate of a suppressed X-linked meiotic driver: experimental evolution in Drosophila simulans

H. Bastide, D. Ogereau, C. Montchamp-Moreau and P. R. Gérard,  Chromosome Research,  2022.
Sex-ratio (SR) meiotic drivers are X-linked selfish genetic elements that promote their own transmission by preventing the production of Y-bearing sperm, which usually lowers male fertility. The spread of SR drivers in populations is expected to trigger the evolution of unlinked ...
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Epistatic selection on a selfish Segregation Distorter supergene: drive, recombination, and genetic load

B. Navarro-Dominguez, C.-H. Chang, C. L. Brand, C. A. Muirhead, D. C. Presgraves and A. M. Larracuente,  eLife,  11:e78981. 2022.
In this work, we investigate the evolution and genomic consequences of an autosomal, multilocus, male meiotic drive system, Segregation Distorter (SD) in the fruit fly, Drosophila melanogaster. In African populations, the predominant SD chromosome variant, SD-Mal, is ...
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The evolutionary significance of meiotic drive

J. B. Searle and F. P.-M. de Villena,  Heredity,  2022.
In this essay, we will focus on‘true meiotic drive’ where the distorted transmission does arise within meiosis itself (Zanders and Unckless2019),specifically in females. Here, the non-transmission of one of the products of meiotic division is inherent in the gametogenic ...
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Meiotic drive in chronic lymphocytic leukemia compared with other malignant blood disorders

V. Jonsson, H. Awan, N. D. Jones, T. B. Johannesen, K. Thogersen, B. A. Steig, G. Andorsdottir and G. E. Tjonnfjord,  Scientific Reports,  12:6138. 2022.
The heredity of the malignant blood disorders, leukemias, lymphomas and myeloma, has so far been largely unknown. The present study comprises genealogical investigations of one hundred and twelve Scandinavian families with unrelated parents and two or more cases of malignant ...
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Explainer: The Gene Drive Technology

P. Shah,  CRISPR Medicine News,  2022.
Gene drives are genetic elements that can quickly spread through populations and have nearly a 100% chance of passing the genes they carry to the next generation. Synthetic gene drive is a technology of genetic engineering through which certain desired traits can be introduced to ...
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Evolution of eukaryotic centromeres by drive and suppression of selfish genetic elements

T. Kumon and M. A. Lampson,  Seminars in Cell and Developmental Biology,  2022.
Despite the universal requirement for faithful chromosome segregation, eukaryotic centromeres are rapidly evolving. It is hypothesized that rapid centromere evolution represents an evolutionary arms race between selfish genetic elements that drive, or propagate at the expense of ...
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Genetic Drive Systems in Nature

David O'Brochta and Hector Quemada,  GeneConvene Global Collaborative,  2022.
Intra genomic genetic conflicts are ubiquitous in nature and have shaped and continue to shape the evolution of plants, animals, and microbes. These conflicts can result in preferential transmission - drive - of genes, various genetic elements, and even whole chromosomes. ...
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Selfish migrants: How a meiotic driver is selected to increase dispersal

J. N. Runge, H. Kokko and A. K. Lindholm,  J Evol Biol,  2022.
Meiotic drivers are selfish genetic elements that manipulate meiosis to increase their transmission to the next generation to the detriment of the rest of the genome. One example is the t haplotype in house mice, which is a naturally occurring meiotic driver with deleterious ...
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A-to-I mRNA editing controls spore death induced by a fungal meiotic drive gene in homologous and heterologous expression systems

J. M. Lohmar, N. A. Rhoades, T. N. Patel, R. H. Proctor, T. M. Hammond and D. W. Brown,  Genetics,  2022.
Spore killers are meiotic drive elements that can block development of sexual spores in fungi. In the maize ear rot and mycotoxin-producing fungus Fusarium verticillioides, a spore killer called SkK has been mapped to a 102-kb interval of chromosome V. Here, we show that a gene ...
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Hoisted with his own petard: how sex-ratio meiotic drive in Drosophila affnis creates resistance alleles that limit its spread

W.-J. Ma, K. B. Patch, E. M. Knoles, M. M. Shoaib and R. L. Unckless,  bioRxiv,  2022.02.14.480432. 2022.
Meiotic drivers are selfish genetic elements that tinker with gameto-genesis to bias their own transmission into the next generation of off-spring. Such tinkering can have significant consequences on gameto-genesis and end up hampering the spread of the driver. In Drosophila ...
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The spore killers, fungal meiotic driver elements

A. A. Vogan, I. Martinossi-Allibert, S. L. Ament-Velásquez, J. Svedberg and H. Johannesson,  Mycologia,  2022.
During meiosis, both alleles of any given gene should have equal chances of being inherited by the progeny. There are a number of reasons why, however, this is not the case, with one of the most intriguing instances presenting itself as the phenomenon of meiotic drive. Genes that ...
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chinmo-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche

C. Y. Tseng, M. Burel, M. Cammer, S. Harsh, M. S. Flaherty, S. Baumgartner and E. A. Bach,  Developmental Cell,  2021.
Niches maintain a finite pool of stem cells via restricted space and short-range signals. Stem cells compete for limited niche resources, but the mechanisms regulating competition are poorly understood. Using the Drosophila testis model, we show that germline stem cells (GSCs) ...
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Diverse mating phenotypes impact the spread of wtf meiotic drivers in Schizosaccharomyces pombe

J. F. L. Hernandez, R. M. Helston, J. J. Lange, R. B. Billmyre, S. H. Schaffner, M. T. Eickbush, S. McCroskey and S. E. Zanders,  Elife,  10:30. 2021.