Keywords: meiotic drive

Deregulation of Y-linked protamine-like genes in sex chromosome-biased spermatid demise

J. I. Park, G. W. Bell and Y. M. Yamashita,  bioRxiv,  2022.
Meiotic drive is a phenomenon wherein a genetic element achieves a higher rate of transmission than dictated by Mendelian segregation (1-3). One proposed mechanism for meiotic drivers to achieve biased transmission is by sabotaging essential processes of gametogenesis (e.g. ...
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Meiotic transmission patterns of additional genomic elements in Brachionus asplanchnoidis, a rotifer with intraspecific genome size variation

J. Blommaert and C.-P. Stelzer,  Scientific Reports,  12:20900. 2022.
Intraspecific genome size (GS) variation in Eukaryotes is often mediated by additional, nonessential genomic elements. Physically, such additional elements may be represented by supernumerary (B-)chromosomes or by large heterozygous insertions into the regular chromosome set. ...
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Meiotic drive adaptive testes enlargement during early development in the stalk-eyed fly

S. L. Bradshaw, L. Meade, J. Tarlton-Weatherall and A. Pomiankowski,  Biology Letters,  18:20220352. 2022.
The sex ratio (SR) X-linked meiotic drive system in stalk-eyed flies destroys Y-bearing sperm. Unlike other SR systems, drive males do not suffer fertility loss. They have greatly enlarged testes which compensate for gamete killing. We predicted that enlarged testes arise from ...
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Discovery of 119-Million-Year-Old “Selfish” Genes Casts Doubt on Established Evolution Beliefs

Stowers Institute for Medical Research,  SciTechDaily,  2022.
Meiotic drivers, a kind of selfish gene, are indeed selfish. They are found in virtually all species’ genomes, including humans, and unjustly transfer their genetic material to more than half of their offspring, resulting in infertility and impaired organism health. Their ...
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Discovery of 119-Million year old Selfish Genes Casts Doubt on Established Evolution Beliefs

Stowers Institute for Medical Research,  Stowers Institute for Medical Research,  2022.
Meiotic drivers, a kind of selfish gene, are indeed selfish. They are found in virtually all species’ genomes, including humans, and unjustly transfer their genetic material to more than half of their offspring, resulting in infertility and impaired organism health. Their ...
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Driving lessons: a brief (personal) history of centromere drive

H. S. Malik,  Genetics,  2022.
Meiosis is an important specialized cell division in many eukaryotic species, including fungi, plants, and animals. Meiosis results in the production of haploid gametes starting from a diploid cell via 1 round of replication and 2 rounds of cell division. In an influential ...
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Centromere drive: chromatin conflict in meiosis

P. Talbert and S. Henikoff,  Current Opinion in Genetics and Development,  77:102005. 2022.
Centromeres are essential loci in eukaryotes that are necessary for the faithful segregation of chromosomes in mitosis and meiosis. Centromeres organize the kinetochore, the protein machine that attaches sister chromatids or homologous chromosomes to spindle microtubules and ...
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Centromere drive: chromatin conflict in meiosis

P. Talbert and S. Henikoff,  Current Opinion in Genetics and Development,  77:102005. 2022.
Centromeres are essential loci in eukaryotes that are necessary for the faithful segregation of chromosomes in mitosis and meiosis. Centromeres organize the kinetochore, the protein machine that attaches sister chromatids or homologous chromosomes to spindle microtubules and ...
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119-Million-Year-Old “Selfish” Genes Uncovered in Yeast

Stowers Institute for Medical Research,  Technology Networks,  2022.
Meiotic drivers, a type of selfish gene, are indeed selfish. Present in the genomes of nearly all species, including humans, they unfairly transfer their genetic material to more than half of their offspring, sometimes leading to infertility, and decreased organism health. ...
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The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years

M. De Carvalho, G. S. Jia, A. Nidamangala Srinivasa, R. B. Billmyre, Y. H. Xu, J. J. Lange, I. M. Sabbarini, L. L. Du and S. E. Zanders,  eLife,  11. 2022.
Meiotic drivers are selfish elements that bias their own transmission into more than half of the viable progeny produced by a driver+/driver- heterozygote. Meiotic drivers are thought to exist for relatively short evolutionary timespans because a driver gene or gene family is ...
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Meiotic defects in human oocytes: Potential causes and clinical implications

T. Wu, H. Gu, Y. Luo, L. Wang and Q. Sang,  BioEssays,  2022.
Meiotic defects cause abnormal chromosome segregation leading to aneuploidy in mammalian oocytes. Chromosome segregation is particularly error-prone in human oocytes, but the mechanisms behind such errors remain unclear. To explain the frequent chromosome segregation errors, ...
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Mitotic exchange in female germline stem cells is the major source of Sex Ratio chromosome recombination in Drosophila pseudoobscura

S. Koury,  G3 Genes|Genomes|Genetics,  2022.
Sex Ratio chromosomes in Drosophila pseudoobscura are selfish X chromosome variants associated with three non-overlapping inversions. In the male germline, Sex Ratio chromosomes distort segregation of X and Y chromosomes (99:1), thereby skewing progeny sex ratio. In the female ...
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Meiotic drive is associated with sexual incompatibility in Neurospora

A. Vogan, J. Svedberg, M. Grudzinska-Sterno and H. Johannesson,  Evolution,  2022.
Evolution of Bateson-Dobzhansky-Muller (BDM) incompatibilities is thought to represent a key step in the formation of separate species. They are incompatible alleles that have evolved in separate populations and are exposed in hybrid offspring as hybrid sterility or lethality. In ...
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Meiotic drive does not impede success in sperm competition in the stalk-eyed fly, Teleopsis dalmanni

S. Bates, L. Meade and A. Pomiankowski,  bioRxiv,  2022.
Meiotic drive genes are selfish genetic elements that distort Mendelian patterns of inheritance to bias transmission in their favour. We use the stalk-eyed fly, Teleopsis dalmanni, to investigate the fitness effects associated with a meiotic drive gene called Sex Ratio (SR), ...
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Enforcement of Postzygotic Species Boundaries in the Fungal Kingdom

J. Y. Chou, P. C. Hsu and J. Y. Leu,  Microbiology and Molecular Biology Reviews,  2022.
Understanding the molecular basis of speciation is a primary goal in evolutionary biology. The formation of the postzygotic reproductive isolation that causes hybrid dysfunction, thereby reducing gene flow between diverging populations, is crucial for speciation. Using various ...
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On the Mechanistic Basis of Killer Meiotic Drive in Fungi

S. J. Saupe and H. Johannesson,  Annual Review of Microbiology,  76:305-323. 2022.
Spore killers are specific genetic elements in fungi that kill sexual spores that do not contain them. A range of studies in the last few years have provided the long-awaited first insights into the molecular mechanistic aspects of spore killing in different fungal models, ...
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Hoisted with his own petard: How sex-ratio meiotic drive in Drosophila affinis creates resistance alleles that limit its spread

W. J. Ma, E. M. Knoles, K. B. Patch, M. M. Shoaib and R. L. Unckless,  J Evol Biol,  2022.
Meiotic drivers are selfish genetic elements that tinker with gametogenesis to bias their own transmission into the next generation of offspring. Such tinkering can have significant consequences on gametogenesis and end up hampering the spread of the driver. In Drosophila ...
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Non-Mendelian transmission of accessory chromosomes in fungi

J. Komluski, E. H. Stukenbrock and M. Habig,  Chromosome Research,  2022.
Non-Mendelian transmission has been reported for various genetic elements, ranging from small transposons to entire chromosomes. One prime example of such a transmission pattern are B chromosomes in plants and animals. Accessory chromosomes in fungi are similar to B chromosomes ...
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“Selfish Genetic Elements” – Supergene Wreaks Havoc in a Genome

University of Rochester,  SciTechDaily,  2022.
“Selfish genetic elements” litter the human genome. They do not seem to benefit their hosts but instead seek only to propagate themselves. These selfish genetic elements can wreak havoc. For example, they can distort sex ratios, impair fertility, cause harmful mutations, and ...
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What can we learn from selfish loci that break Mendel’s law?

S. E. Zanders,  PLOS Biology,  20:e3001700. 2022.
Mendel’s law of segregation provides a critical foundation for genetic inquiry It is not, however, without exceptions Historically, 2 such exceptions (sex chromosome linkage and chromosome missegregation in meiosis) were used by Drosophila geneticists to help demonstrate ...
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Adaptive meiotic drive in selfing populations with heterozygote advantage

E. Brud,  Theoretical Population Biology,  146:61-70. 2022.
The egalitarian allotment of gametes to each allele at a locus (Mendel's law of segregation) is a near-universal phenomenon characterizing inheritance in sexual populations. As exceptions to Mendel's law are known to occur, one can investigate why non-Mendelian segregation is not ...
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Meiotic drive in house mice: mechanisms, consequences, and insights for human biology

U. P. Arora and B. L. Dumont,  Chromosome Research,  2022.