Keywords: meiotic drive

Distinct spermiogenic phenotypes underlie sperm elimination in the Segregation Distorter meiotic drive system

M. Herbette, X. L. Wei, C. H. Chang, A. M. Larracuente, B. Loppin and R. Dubruille,  PLOS Genetics,  17:26. 2021.
Here we show that SD/SD+ males of different genotypes but with similarly strong degrees of distortion have distinct spermiogenic phenotypes. In some genotypes, SD+ spermatids fail to fully incorporate protamines after the removal of histones, and degenerate during the ...
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First evidence of deviation from Mendelian proportions in a conservation programme

C. E. Grueber, K. A. Farquharson, B. R. Wright, G. P. Wallis, C. J. Hogg and K. Belov,  Molecular Ecology,  13. 2021.
Classic Mendelian inheritance is the bedrock of population genetics and underpins pedigree-based management of animal populations. However, assumptions of Mendelian inheritance might not be upheld in conservation breeding programmes if early viability selection occurs, even when ...
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Experiments confirm a dispersive phenotype associated with a natural gene drive system

J.-N. Runge and A. K. Lindholm,  Royal Society Open Science,  8:202050. 2021.
Meiotic drivers are genetic entities that increase their own probability of being transmitted to offspring, usually to the detriment of the rest of the organism, thus ‘selfishly’ increasing their fitness. In many meiotic drive systems, driver-carrying males are less ...
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An introgressed gene causes meiotic drive in Neurospora sitophila

J. Svedberg, A. A. Vogan, N. A. Rhoades, D. Sarmarajeewa, D. J. Jacobson, M. Lascoux, T. M. Hammond and H. Johannesson,  Proceedings of the National Academy of Sciences of the United States of America,  118:9. 2021.
Meiotic drive elements cause their own preferential transmission following meiosis. In fungi, this phenomenon takes the shape of spore killing, and in the filamentous ascomycete Neurospora sitophila, the Sk-1 spore killer element is found in many natural populations. In this ...
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Invasion and maintenance of meiotic drivers in populations of ascomycete fungi

I. Martinossi-Allibert, C. Veller, S. L. Ament-Velasquez, A. A. Vogan, C. Rueffler and H. Johannesson,  Evolution,  20. 2021.
Meiotic drivers (MDs) are selfish genetic elements that are able to become overrepresented among the products of meiosis. This transmission advantage makes it possible for them to spread in a population even when they impose fitness costs on their host organisms. Whether an MD ...
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Meiotic drive does not cause condition-dependent reduction of the sexual ornament in stalk-eyed flies

S. R. Finnegan, M. Mondani, K. Fowler and A. Pomiankowski,  Journal of Evolutionary Biology,  11. 2021.
Meiotic drive systems are associated with low-frequency chromosomal inversions. These are expected to accumulate deleterious mutations due to reduced recombination and low effective population size. We test this prediction using the 'sex-ratio' (SR) meiotic drive system of the ...
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Holocentric Chromosomes Probably Do Not Prevent Centromere Drive in Cyperaceae

M. Kratka, J. Smerda, K. Lojdova, P. Bures and F. Zedek,  Frontiers in Plant Science,  12:9. 2021.
In response to these selfish centromeres, the histone protein CenH3, which recruits kinetochore components, adaptively evolves to restore chromosomal parity and counter the detrimental effects of centromere drive. Holocentric chromosomes, whose kinetochores are assembled along ...
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Widespread haploid-biased gene expression enables sperm-level natural selection

K. Bhutani, K. Stansifer, S. Ticau, L. Bojic, A.-C. Villani, J. Slisz, C. M. Cremers, C. Roy, J. Donovan, B. Fiske and R. C. Friedman,  Science,  eabb1723. 2021.
Here, we show that a large class of mammalian genes are not completely shared across these bridges. We term these genes “genoinformative markers” (GIMs) and show that a subset can act as selfish genetic elements that spread alleles unevenly through murine, bovine, and human ...
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Whole-genome resequencing reveals loci with allelic transmission ratio distortion in F1 chicken population

P. Ren, F. Deng, S. Chen, J. Ran, J. Li, L. Yin, Y. Wang, H. Yin, Q. Zhu and Y. Liu,  Molecular Genetics and Genomics,  2021.
In this study, whole-genome resequencing technology was applied to reveal TRD loci in chicken by constructing a full-sib F1 hybrid population. Through the whole-genome resequencing data of two parents (30 ×) and 38 offspring (5 ×), we detected a total of 2850 TRD SNPs ...
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A test for meiotic drive in hybrids between Australian and Timor zebra finches

U. Knief, W. Forstmeier, Y. Pei, J. Wolf and B. Kempenaers,  Ecology and Evolution,  2020.
We did not find evidence for meiotic driver loci on specific chromosomes. However, we observed a weak overall transmission bias toward Timor alleles at centromeres in females (transmission probability of Australian alleles of 47%, nominal p = 6 ? 10?5). While this is in line ...
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Cellular mechanisms regulating synthetic sex ratio distortion in the Anopheles gambiae germline

R. E. Haghighat-Khah, A. Sharma, M. R. Wunderlich, G. Morselli, L. A. Marston, C. Bamikole, A. Hall, N. Kranjc, C. Taxiarchi, I. Sharakhov and R. Galizi,  Pathogens and Global Health,  114:370-378. 2020.
Meiotic cleavage of rDNA repeats, located in the sex chromosomes of A. gambiae SD males, affects the competitiveness of mature sperm to fertilize the female oocyte.
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Selfish genetic elements and male fertility

R. L. Verspoor, T. A. R. Price and N. Wedell,  Philosophical Transactions of the Royal Society B-Biological Sciences,  375:7. 2020.
Selfish genetic elements (SGEs) are diverse and near ubiquitous in Eukaryotes and can be potent drivers of evolution. Here, we discuss SGEs that specifically act on sperm to gain a transmission advantage to the next generation. The diverse SGEs that affect sperm often impose ...
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Engineering the Composition and Fate of Wild Populations with Gene Drive

B. A. Hay, G. Oberhofer and M. Guo,  Annual Review of Entomology,  2020.
We describe technologies under consideration, progress that has been made, and remaining technological hurdles, particularly with respect to evolutionary stability and our ability to control the spread and ultimate fate of genes introduced into populations.
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Resistance to natural and synthetic gene drive systems

T. A. R. Price, N. Windbichler, R. L. Unckless, A. Sutter, J.-N. Runge, P. A. Ross, A. Pomiankowski, N. L. Nuckolls, C. Montchamp-Moreau, N. Mideo, O. Y. Martin, A. Manser, M. Legros, A. M. Larracuente, L. Holman, J. Godwin, N. Gemmell, C. Courret, A. Buc,  Journal of Evolutionary Biology,  2020.
This review summarizes our current knowledge of drive resistance in both natural and synthetic gene drives. We explore how insights from naturally occurring and synthetic drive systems can be integrated to improve the design of gene drives, better predict the outcome of releases ...
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Maternal Transmission Ratio Distortion in Two Iberian Pig Varieties

M. Vazquez-Gomez, M. M. de Hijas-Villalba, L. Varona, N. Ibanez-Escriche, J. P. Rosas, S. Negro, J. L. Noguera and J. Casellas,  Genes,  11:16. 2020.
Although TRD can be a confounding factor in genetic mapping studies, this phenomenon remains mostly unknown in pigs, particularly in traditional breeds (i.e., the Iberian pig). We aimed to describe the maternal TRD prevalence and its genomic distribution in two Iberian varieties. ...
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Survival of the fit-ish

Stowers Institute for Medical Research,  Science Daily,  2020.
In a paper published online August 13, 2020, in eLife, members of the Zanders lab explain how it could be possible that meiotic drivers persist in the population, even as they kill off many would-be hosts. It turns out that S. pombe can employ variants of other genes to help ...
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Atypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic drivers

M. A. Bravo Núñez, I. M. Sabbarini, L. E. Eide, R. L. Unckless and S. E. Zanders,  eLife,  9:e57936. 2020.
Here, we demonstrate that in scenarios analogous to outcrossing, wtf drivers generate a fitness landscape in which atypical spores, such as aneuploids and diploids, are advantageous. In this context, wtf drivers can decrease the fitness costs of mutations that disrupt meiotic ...
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Maternal effect killing by a supergene controlling ant social organization

A. Avril, J. Purcell, S. Béniguel and M. Chapuisat,  Proceedings of the National Academy of Sciences,  2020.
Supergenes are clusters of linked loci producing complex alternative phenotypes. In a series of experiments, we demonstrate that a supergene controlling ant social organization distorts Mendel’s laws to enhance its transmission to adult offspring. One supergene haplotype is ...
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Invasion and maintenance of spore killers in populations of ascomycete fungi

I. Martinossi-Allibert, C. Veller, S. L. Ament-Velásquez, A. A. Vogan, C. Rueffler and H. Johannesson,  bioRxiv,  2020.04.06.026989. 2020.
We show how ploidy level, rate of selfing, and efficiency of spore killing affect the invasion probability of a driving allele and the conditions for its stable coexistence with the non-driving allele. Our model can be adapted to different fungal life-cycles, and is applied here ...
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Can natural gene drives be part of future fungal pathogen control strategies in plants?

D. M. Gardiner, A. Rusu, L. Barrett, G. C. Hunter and K. Kazan,  New Phtologist,  2020.
Globally, fungal pathogens cause enormous crop losses and current control practices are not always effective, economical or environmentally sustainable. Tools enabling genetic management of wild pathogen populations could potentially solve many problems associated with plant ...
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Analysis of a Strong Suppressor of Segregation Distorter inDrosophila melanogaster

R. G. Temin,  Genetics,  215:1085-1105. 2020.
These studies highlight the polygenic nature of distortion and its dependence on a constellation of positive and negative modifiers, provide insight into the stability of Mendelian transmission in natural populations even when a drive system arises, and pave the way for molecular ...
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Meiotic drive

A. N. Srinivasa and S. E. Zanders,  Current Biology,  30:R627-R629. 2020.
What is meiotic drive? Diploid organisms, like you, have two copies of each autosomal chromosome, one from each parent. Sometimes organisms are heterozygous at a given region, meaning they carry different copies (or alleles) of the DNA sequence on the two homologous chromosomes. ...
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A Protamine Knockdown Mimics the Function of Sd in Drosophila melanogaster

L. F. Gingell and J. R. McLean,  G3-Genes Genomes Genetics,  10:2111-2115. 2020.
Segregation Distorter (SD) is an autosomal meiotic drive system found worldwide in natural populations of Drosophila melanogaster. This gene complex induces the preferential and nearly exclusive transmission of the SD chromosome in SD/SD+ males. This selfish propagation occurs ...
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The Y Chromosome as a Battleground for Intragenomic Conflict

D. Bachtrog,  Trends in Genetics,  2020.