Keywords: mice
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Meiotic drive of noncentromeric loci in mammalian meiosis II eggsD. M. Silva and T. Akera, Curr Opin Genet Dev, 81:102082. 2023.
The germline produces haploid gametes through a specialized cell division called meiosis. In general, homologous chromosomes from each parent segregate randomly to the daughter cells during meiosis, providing parental alleles with an equal chance of transmission. Meiotic drivers ... |
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Probing “Selfish” Centromeres Unveils an Evolutionary Arms RaceM. Lampson, The Scientist, 2023.
The so-called Robertsonian (Rb) fusions that led to these rapid karyotype changes are relatively common chromosomal rearrangements. But their accumulation in the populations of Madeira Island and in multiple other isolated mouse populations elsewhere is likely due to another ... |
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Gene drive-mediated population elimination for biodiversity conservation. When you come to a fork in the road, take itB. A. Hay and M. Guo, Proceedings of the National Academy of Sciences, 119:e2218020119. 2022.
How can the ability of t w2 to spread at super-Mendelian frequencies be utilized even if it is unable to directly drive the population to an unfit state? Gierus, Birand, and colleagues proposed placing Cas9 and a gRNA at a neutral position within the t haplotype. In this hybrid ... |
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New CRISPR tech makes it possible to wipe out invasive mice, 2022. |
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A natural gene drive could steer invasive rodents on islands to extinctionB. Brookshire, ScienceNews, 2022.
In the battle against the invasive house mouse on islands, scientists are using the rodent’s own genes against it. With the right tweaks, introducing a few hundred genetically altered mice could drive an island’s invasive mouse population to extinction in about 25 years, ... |
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Gene drive could be used to wipe out invasive mice on islandsM. Le Page, NewScientist, 2022.
For the first time, researchers have created a gene drive – a kind of genetic parasite – that could be used to eradicate mammalian pests such as mice by making them infertile. The technology could provide a humane alternative to the poison baits currently used to tackle ... |
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World first trial to eradicate mice through gene modificationI. Mannix, COSMOS, 2022.
Mouse populations could be eradicated in some areas through new gene modification technology to render female mice infertile. The technology – called t-CRISPR – was previously developed to target malaria-transmitting mosquitoes. This is the first proof of concept for its use ... |
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Gene drive technology to suppress invasive miceUniversity of Adelaide, Phys Org, 2022.
Researchers at the University of Adelaide have released their first findings on the potential effectiveness of revolutionary gene drive technology to control invasive mice. The team has developed a world-first proof of concept for the technology—called t-CRISPR—using ... |
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Leveraging a natural murine meiotic drive to suppress invasive populationsL. Gierus, A. Birand, M. D. Bunting, G. I. Godahewa, S. G. Piltz, K. P. Oh, A. J. Piaggio, D. W. Threadgill, J. Godwin, O. Edwards, P. Cassey, J. V. Ross, T. A. A. Prowse and P. Q. Thomas, Proceedings of the National Academy of Sciences, 119:e2213308119. 2022.
Invasive rodents are a major cause of environmental damage and biodiversity loss, particularly on islands. Unlike insects, genetic biocontrol strategies including population-suppressing gene drives with biased inheritance have not been developed in mice. Here, we demonstrate a ... |
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Generation of Gene Drive Mice for Invasive Pest Population SuppressionM. D. Bunting, C. Pfitzner, L. Gierus, M. White, S. Piltz and P. Q. Thomas, Applications of Genome Modulation and Editing, 2022.
Gene drives are genetic elements that are transmitted to greater than 50% of offspring and have potential for population modification or suppression. While gene drives are known to occur naturally, the recent emergence of CRISPR-Cas9 genome-editing technology has enabled ... |
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A meiotic driver alters sperm form and function in house mice: a possible example of spiteL. Winkler and A. K. Lindholm, Chromosome Research, 2022.
The ability to subvert independent assortment of chromosomes is found in many meiotic drivers, such as the t haplotype in house mice Mus musculus, in which the t-bearing chromosomal homolog is preferentially transmitted to offspring. This is explained by a poison-antidote system, ... |
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Bayesian network-based risk assessment of synthetic biology: Simulating CRISPR-Cas9 gene drive dynamics in invasive rodent managementE. A. Brown, S. R. Eikenbary and W. G. Landis, Risk Analysis, 2022.
Gene drive technology has been proposed to control invasive rodent populations as an alternative to rodenticides. However, this approach has not undergone risk assessment that meets criteria established by Gene Drives on the Horizon, a 2016 report by the National Academies of ... |
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Selfish migrants: How a meiotic driver is selected to increase dispersalJ. N. Runge, H. Kokko and A. K. Lindholm, J Evol Biol, 2022.
Meiotic drivers are selfish genetic elements that manipulate meiosis to increase their transmission to the next generation to the detriment of the rest of the genome. One example is the t haplotype in house mice, which is a naturally occurring meiotic driver with deleterious ... |
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Could we delete diseases passed down through our DNA?E. Rayne, SYFY, 2022.
What has now been proven possible was once the stuff of science fiction dreams. CRISPR has shown it can successfully edit out detrimental genetic conditions before they are inherited — which could mean the beginning of the end for hereditary diseases. It could also help ... |
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Scientists expand CRISPR-Cas9 genetic inheritance control in mammalsM. Aguilera, Phys Org, 2022.
Led by graduate student Alexander Weitzel, Grunwald, Cooper and their colleagues have now succeeded in developing CRISPR-Cas9 inheritance control in male mice by shifting the gene editing window to more closely match the timing of meiosis in both sexes. Their results were ... |
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Scientists Used CRISPR Gene Editing to Choose the Sex of Mouse PupsS. Fan, Singuarity Hub, 2021.
“Do you want a boy or a girl?” can be an awkward question.But in certain circles, it’s a question that’s asked every day. Take agriculture. In a perfect world, most cows would only birth females. Chicks would grow up to be all hens. “Sexing” a farm animal when ... |
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Gene editing used to create all-male or all-female litters of miceJ. Goodyer, Science Focus, 2021.
As males are unable to produce milk or lay eggs, the ability to breed cows and hens that produce all-female litters is likely to be high on most poultry and dairy farmers’ wish lists. Now, scientists at the Francis Crick Institute and the University of Kent have come a step ... |
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Gene editing used to create all-male or all-female mice littersA. Reis, European Scientist, 2021.
Researchers from the Francis Crick Institute and the University of Kent used gene-editing technologies to create male-only and female-only mice litters, according to a study published in Nature Communications (1). The authors also suggested ways in which this method could be used ... |
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Gene-editing used to create single sex mice littersThe Francis Crick Institute, Phys Org, 2021.
Scientists at the Francis Crick Institute, in collaboration with University of Kent, have used gene editing technology to create female-only and male-only mice litters with 100% efficiency. This proof of principle study, published in Nature Communications today, demonstrates how ... |
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Single-sex mice litters were created with 100% efficiency using gene editing.R. Silman, Brinkwire, 2021.
The Francis Crick Institute, in partnership with the University of Kent, has employed gene editing technology to construct 100% efficient female-only and male-only mouse litters. This proof-of-concept study, which was published today (Friday, December 3rd, 2021) in Nature ... |
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Lab animals: Gene-editing technology is used to create female-only and male-only mice litterstodayuknews, Today UK News, 2021.
Single-sex litters of mice — comprising only either female or male pups — have been produced by means of so-called CRISPR-Cas9 gene editing technology. The technique, developed by experts at the Francis Crick Institute and the University of Kent, works by inactivating embryos ... |
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Gene editing produces all-male or all-female litters of miceE. Pennisi, Science, 2021.
In some farmers’ ideal world, cows would birth only females, sows would bear no boars, and chicks would all grow up to be hens. Such sex ratios would stop them from killing millions of male animals, which don’t produce eggs or milk. Now, scientists are a step closer to this ... |
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Transmission distortion and genetic incompatibilities between alleles in a multigenerational mouse advanced intercross lineD. Arends, S. Kärst, S. Heise, P. Korkuc, D. Hesse and G. A. Brockmann, Genetics, 2021.
While direct additive and dominance effects on complex traits have been mapped repeatedly, additional genetic factors contributing to the heterogeneity of complex traits have been scarcely investigated. To assess genetic background effects, we investigated transmission ratio ... |
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$1M in funding for project to cull mouse plaguesK. Brown, University of Adelaide NEWSROOM, 2021.
South Australian researchers are set to use genetic tools to help find innovative solutions to the devastating mouse plagues that have caused massive economic damage to Australian farmers.The University of Adelaide has been awarded $1 million in funding from the South Australian ... |
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Patterns and mechanisms of sex ratio distortion in the Collaborative Cross mouse mapping populationB. A. Haines, F. Barradale and B. L. Dumont, Genetics, 219:iyab136. 2021.
In species with single-locus, chromosome-based mechanisms of sex determination, the laws of segregation predict an equal ratio of females to males at birth. Here, we show that departures from this Mendelian expectation are commonplace in the 8-way recombinant inbred Collaborative ... |
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Invasive Species Management: Informing Gene Drive ConsiderationsDavid O'Brochta and Hector Quemada, GeneConvene Global Collaborative, 2021.
The management, control and elimination of invasive species involves solving problems that have analogs to those anticipating the use of gene drive technologies to control and eliminate malaria in Africa. Avoiding unintended consequences from interventions designed to reduce or ... |
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Mice Plague Eastern Australia in Record NumbersB. Nogrady, The Scientist, 2021.
Just before Christmas last year, Julie Leven and her husband Des took their camper up to visit their son in northern New South Wales, Australia. Driving back at night to their home in Gilgandra, around 430 kilometers northwest of Sydney, they saw masses of white spots moving ... |
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Patterns and Mechanisms of Sex Ratio Distortion in the Collaborative Cross Mouse Mapping PopulationB. A. Haines, F. Barradale and B. L. Dumont, bioRxiv, 2021.
In species with single-locus chromosome-based mechanisms of sex determination, the laws of segregation predict an equal ratio of females to males at birth. Here, we show that departures from this Mendelian expectation are commonplace in the 8-way recombinant inbred Collaborative ... |
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Victory: NSW Government Invests in Humane Mice Control!PETA Australia, PETA Australia, 2021.
Just two weeks after calling us “brainless” for suggesting that the state government invest in more ethical, eco-friendly methods of mice control – Minister for Agriculture Adam Marshall announced a $1.8 million package to “fast-track the delivery of next generation ... |
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New biocontrol research to help prevent mice plaguesAnonymous, The National Tribune, 2021.
Scientists at the University of Adelaide are partnering with the CSIRO and the Centre for Invasive Species Solutions on breakthrough genetic biocontrol research to help control mice populations and prevent future mice plagues. The three-year research program will identify fast ... |
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Gene drive could be a game changer for future mouse control.Anonymous, Centre for Invasive Species Solutions, 2021.
We are proud to announce we will be coordinating a brand new, three-year program of genetic biocontrol research, which will identify fast acting gene drives designed to spread an inherited characteristic through a population at higher-than-normal rates. Using targeted gene ... |
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“Gene Drive” Technology To Control Mouse Invasions | Liverpool City ChampionT. Carrington, Liverpool IL, 2021.
As western New South Wales faces a devastating mouse plague, the government is investing in groundbreaking genetic biocontrol research that could transform pest management in Australia. Agriculture Minister Adam Marshall said the NSW government will provide $ 1.8 million for the ... |
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Scientists want to alter rodent genes to prevent mice plaguesP. Hannon, The Sydney Morning Herald, 2021.
Mice plagues, such as the one ravaging parts of inland NSW, could become a thing of the past if scientists succeed in modifying the genes of the rodents so that populations crash before they can take off. Paul Thomas, a researcher at the University of Adelaide, is part of an ... |
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Meiotic Cas9 expression mediates genotype conversion in the male and female mouse germline.A. J. Weitzel, H. A. Grunwald, R. Levina, V. M. Gantz, S. M. Hedrick, E. Bier and K. L. Cooper, 2021.03.16.435716, 2021.
We previously showed that such a system of genotype conversion from heterozygous to homozygous after a sequence targeted CRISPR/Cas9 double strand DNA break is feasible in the female mouse germline. In the male germline, however, all double strand breaks were instead repaired by ... |
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Polyandry blocks gene drive in a wild house mouse populationA. Manser, B. Konig and A. K. Lindholm, Nature Communications, 11:8. 2020.
Here, we study the impact of polyandry on a well-known gene drive, called t haplotype, in an intensively monitored population of wild house mice. First, we show that house mice are highly polyandrous: 47% of 682 litters were sired by more than one male. Second, we find that ... |
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Progress Toward Zygotic and Germline Gene Drives in MiceC. Pfitzner, M. A. White, S. G. Piltz, M. Scherer, F. Adikusuma, J. N. Hughes and P. Q. Thomas, The CRISPR Journal, 3:388-397. 2020.
Here, we investigated the efficiency of CRISPR-Cas9-based gene drives in Mus musculus by constructing "split drive" systems where gRNA expression occurs on a separate chromosome to Cas9, which is under the control of either a zygotic (CAG) or germline (Vasa) promoter. |
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Viewpoint: Is there a scientific basis to ban gene drive technology that can rid us of virus-carrying rodents and mosquitoes?K. Vavitas, Genetic Literacy Project, 2020.
Gene drives may be invaluable tools to control the spread of parasites, invasive species, and disease carriers. But the technology has faced strong opposition from activist groups and some mainstream scientists based on environmental and food safety. Are these concerns valid? |
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Towards Responsive Eco-technology: The Development of a Male Sex-biased MouseW. Kamau, Massachusetts Institute of Technology, 2020.
CRISPR-Cas systems have catalyzed the emergence of several synthetic population management strategies, like gene drives, for controlling pests and disease vectors. As these technologies garner greater visibility in both general and regulatory audiences, questions have arisen ... |
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Development of zygotic and germline gene drives in miceC. Pfitzner, J. N. Hughes, M. A. White, M. Scherer, S. G. Piltz and P. Q. Thomas, bioRxiv, 2020.
Here we investigated the efficiency of CRISPR/Cas9-based gene drives in Mus musculus by constructing "split drive" systems with Cas9 under the control of zygotic (CAG) or germline (Vasa) promoters. |
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Scenario analysis on the use of rodenticides and sex-biasing gene drives for the removal of invasive house mice on islandsM. E. Serr, R. X. Valdez, K. S. Barnhill-Dilling, J. Godwin, T. Kuiken and M. Booker, Biological Invasions, 2020.
Since the 1960s conservation efforts have focused on recovering island biodiversity by eradicating invasive rodents. These eradication campaigns have led to considerable conservation gains, particularly for nesting seabirds. However, eradications are complex and lengthy endeavors ... |
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A selfish genetic element linked to increased lifespan impacts metabolism in female house miceP. C. Lopes and A. K. Lindholm, Journal of Experimental Biology, 22:4. 2020.
Gene drive systems can lead to the evolution of traits that further enhance the transmission of the driving element. In gene drive, one allele is transmitted to offspring at a higher frequency than the homologous allele. This has a range of consequences, which generally include a ... |
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A selfish genetic element linked to increased lifespan impacts metabolism in female house miceLopes, P. C. and A. K. Lindholm, The Journal of Experimental Biology, 2019:212704. 2019.
Gene drive systems can lead to the evolution of traits that further enhance the transmission of the driving element. In gene drive, one allele is transmitted to offspring at a higher frequency than the homologous allele. This has a range of consequences, which generally include a ... |
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Genetically engineering wild mice to combat Lyme disease: An ecological perspectiveSnow, A. A., BioScience, 69:746-756. 2019.
Genetic engineering of wild populations has been proposed for reducing human diseases by altering pathogens’ hosts. For example, CRISPR- based genome editing may be used to create white-footed mice (Peromyscus leucopus) that are resistant to the Lyme disease ... |
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Effects of a male meiotic driver on male and female transcriptomes in the house mouseA. Lindholm, A. Sutter, S. Kunzel, D. Tautz and H. Rehrauer, Proceedings of the Royal Society B-Biological Sciences, 286:1-8. 2019.
Not all genetic loci follow Mendel's rules, and the evolutionary consequences of this are not yet fully known. Genomic conflict involving multiple loci is a likely outcome, as restoration of Mendelian inheritance patterns will be selected for, and sexual conflict may also arise ... |
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Gene Drive and Thinking AnimalsIsland Conservation, , 2019.
Royden Saah, Island Conservation's GBIRd program manager, recently spoke at the Thinking Animals Summit alongside Leilani Münter, a former professional race car driver and environmental activist. The Genetic Biocontrol of Invasive Rodents partnership (GBIRd) is designed for ... |
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Self-destructing mosquitoes and sterilized rodents: the promise of gene drivesM. Scudellari, Nature, 571:160-162. 2019.
Altering the genomes of entire animal populations could help to defeat disease and control pests, but researchers worry about the consequences of unleashing this new technology. |
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Genetic pest management technologies to control invasive rodentsD. Kanavy and D. Threadgill, Island invasives: scaling up to meet the challenge, 2019.
Many strategies exist to manage invasive pests on islands, ranging from poison to trapping, with varying degrees of success. Genetic technologies are increasingly being applied to insect pests, but so far, not to vertebrates. We are implementing a genetic strategy to eradicate ... |
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Trialling gene drives to control invasive species: what, where and how?T. Harvey-Samuel, K. J. Campbell, M. Edgington and L. Alphey, Island invasives: scaling up to meet the challenge, 2019.
The control of invasive species would be enhanced through the addition of novel, more effective and sustainable pest management methods. One control option yet to be trialled in the field is to deploy transgene-based ‘Gene Drives’: technologies which force the inheritance of ... |
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Towards a genetic approach to invasive rodent eradications: assessing reproductive competitiveness between wild and laboratory miceM. Serr, N. Heard and J. Godwin, Island invasives: scaling up to meet the challenge, 2019.
House mice are significant invasive pests, particularly on islands without native mammalian predators. As part of a multi-institutional project aimed at suppressing invasive mouse populations on islands, we aim to create heavily male-biased sex ratios with the goal of causing the ... |
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A potential new tool for the toolbox: assessing gene drives for eradicating invasive rodent populationsK. J. Campbell, J. R. Saah, P. R. Brown, J. Godwin, F. Gould, G. R. Howald, A. Piaggio, P. Thomas, D. M. Tompkins, D. Threadgill, J. Delborne, D. Kanavy, T. Kuiken, H. Packard, M. Serr and A. Shiels, Island invasives: scaling up to meet the challenge, 2019.
Invasive rodents have significant negative impacts on island biodiversity. All but the smallest of rodent eradications currently rely on island-wide rodenticide applications. Although signifi cant advances have been made in mitigating unintended impacts, rodent eradication on ... |
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Gene drive technology makes mouse offspring inherit specific traits from parentsCooper, KLG, Hannah A., The Conversation, 2019.
As mouse geneticists, we spend a lot of time waiting for mice to make more mice. Their small size, ease of care and willingness to mate have made mice the “mammal of choice” for scientists for more than a century. Indeed, these wriggly fur balls that strike fear in the hearts ... |
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Gene drive tested in mice – Expert ReactionScience Media Centre, Science Media Centre, 2019.
Using CRISPR genome editing, the researchers developed a process to make a gene more likely to be inherited than by chance alone. Their attempts with male mice were unsuccessful, but when it was used in females they increased the inheritance of the desired gene from 50 per cent ... |
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Gene editing research highlights challenges in using CRISPR for pest controlDreaver, C, Radio New Zealand, 2019.
US researchers have had some success in using the gene editing technique CRISPR to test out a gene drive in mice, to modify their genes - highlighting the challenges researchers face if it were to be used in pest eradication. |
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Gene drive, a powerful way to speed genetic inheritance, shown for first time in mammals, UCSD researchers sayFikes, BJ, San Diego Union Tribune, 2019.
Gene drive -- the ability to shortcut genetic inheritance by propelling a gene throughout a population -- has been demonstrated in principle for the first time in mammals.; ; UC San Diego scientists reported this feat in mice in a study released Wednesday in the journal Nature. ... |
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Gene Drives Work in Mice (if They’re Female)Rennie, JC, Jordana, Quanta Magazine, 2019.
Conservationists and bioethicists often regard the packages of engineered DNA called “gene drives” with a mixture of wonder, excitement and dread. Gene drives violate the normal rules of inheritance by making sure they get passed down to all of their host organism’s ... |
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La reacción genética en cadena llega a los mamíferosMediavilla, D, El Pais, 2019.
Un experimento muestra que la edición de los genes puede introducir cambios en especies completas que permitan incluso su extinción en un área geográfica |
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Researchers first to use CRISPR/Cas9 to control genetic inheritance in miceUniversity of California, Phys Org, 2019.
Biologists at the University of California San Diego have developed the world's first CRISPR/Cas9-based approach to control genetic inheritance in a mammal. |
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Scientists rewrite mice DNA so genes can be spread through speciesSample, I, The Guardian, 2019.
Controversial procedure has huge potential to combat diseases such as malaria |
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US scientists overturn genetic inheritance rules in lab miceCookson, C, Financial Times, 2019.
New gene drive technology that could revolutionise biology research has been demonstrated for the first time in mammals, after US scientists overturned the normal rules of genetic inheritance in laboratory mice.; ; Scientists at the University of California San Diego employed the ... |
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On the road to a gene drive in mammalsConklin, BR, Nature, 566:43-45. 2019.
A method for making a version of a gene more likely to be inherited than normal, generating what is called a gene drive, might be used to control insect populations. It has now been reported to work in mammals, too. |
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A Y-chromosome shredding gene drive for controlling pest vertebrate populationsProwse, TAAA, F.; Cassey, P.; Thomas, P.; Ross, J. V., eLife, 8:19. 2019.
Self-replicating gene drives that modify sex ratios or infer a fitness cost could be used to control populations of invasive alien species. The targeted deletion of Y sex chromosomes using CRISPR technology offers a new approach for sex bias that could be incorporated within ... |
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Super-Mendelian inheritance mediated by CRISPR-Cas9 in the female mouse germlineGrunwald, HAG, V. M.; Poplawski, G.; Xu, X. R. S.; Bier, E.; Cooper, K. L., Nature, 566:105-109. 2019.
A gene drive biases the transmission of one of the two copies of a gene such that it is inherited more frequently than by random segregation. Highly efficient gene drive systems have recently been developed in insects, which leverage the sequence-targeted DNA cleavage activity of ... |
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A genetic system for biasing the sex ratio in miceYosef, IEB, Liat; Globus, Rea; Shlomovitz, Inbar; Munitz, Ariel; Gerlic, Motti; Qimron, Udi, EMBO reports, 20:e48269. 2019.
Biasing the sex ratio of populations of different organisms, including plants, insects, crustacean, and fish, has been demonstrated by genetic and non-genetic approaches. However, biasing the sex ratio of mammalian populations has not been demonstrated genetically. Here, we ... |
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Locally Fixed Alleles: A method to localize gene drive to island populationsSudweeks, JH, Brandon; Blondel, Dimitri V.; Campbell, Karl J.; Dhole, Sumit; Eisemann, John D.; Edwards, Owain; Godwin, John; Howald, Gregg R.; Oh, Kevin P.; Piaggio, Antoinette J.; Prowse, Thomas A. A.; Ross, Joshua V.; Saah, J. Royden; Shiels, Aaron B.; Thomas, Paul Q.; Threadgill, David W.; Vella, Michael R.; Gould, Fred; Lloyd, Alun L., Scientific Reports, 9:15821. 2019.
Invasive species pose a major threat to biodiversity on islands. While successes have been achieved using traditional removal methods, such as toxicants aimed at rodents, these approaches have limitations and various off-target effects on island ecosystems. Gene drive ... |
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Controlling invasive rodents via synthetic gene drive and the role of polyandryManser, AC, S. J.; Sutter, A.; Blondel, D. V.; Serr, M.; Godwin, J.; Price, T. A. R., Proceedings of the Royal Society B-Biological Sciences, 286:9. 2019.
House mice are a major ecosystem pest, particularly threatening island ecosystems as a non-native invasive species. Rapid advances in synthetic biology offer new avenues to control pest species for biodiversity conservation. Recently, a synthetic sperm-killing gene drive ... |
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Genetic manipulation of sex ratio in mammals: the Reaper comes for MickeySmanski, MJZ, David, EMBO reports, 20:e48577. 2019.
In most animals, sexual reproduction results in a 1:1 ratio of females to males. For several sectors of agriculture, for example, milk or egg production, only a single sex is needed. Biasing the sex ratio so that only offspring of the desired sex are produced has the potential to ... |
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Sustainability as a framework for considering gene drive mice for invasive rodent eradicationBarnhill-Dilling, SKS, M.; Blondel, D. V.; Godwin, J., Sustainability, 11:1334. 2019.
Gene drives represent a dynamic and controversial set of technologies with applications that range from mosquito control to the conservation of biological diversity on islands. Currently, gene drives are being developed in mice that may one day serve as an important tool for ... |
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CRISPR Gene Drive (Complete guide 2019)Every Cell A Universe, , 2018.
Crispr gene drive - malaria cure and a new way to look at conservation. |
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Gene DriveCollins, CH, Scientific American, 2018.
Research into a genetic engineering technology that can permanently change the traits of a population or even an entire species is progressing rapidly. The approach uses gene drives—genetic elements that pass from parents to unusually high numbers of their offspring, thereby ... |
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Gene DriveCollins, CH, Scientific American, 2018.
Research into a genetic engineering technology that can permanently change the traits of a population or even an entire species is progressing rapidly. The approach uses gene drives—genetic elements that pass from parents to unusually high numbers of their offspring, thereby ... |
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Developing gene drive technologies to eradicate invasive rodents from islandsC. M. Leitschuh, D. Kanavy, G. A. Backus, R. X. Valdez, M. Serr, E. A. Pitts, D. Threadgill and J. Godwin, Journal of Responsible Innovation, 5:S121-S138. 2018.
Gene drive methods of rodent eradication offer an alternative to killing that has the potential to be more species-specific, more humane, and more biologically safe for use around humans. Implementing this technology would involve releasing laboratory-developed engineered mice ... |
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Carrying a selfish genetic element predicts increased migration propensity in free-living wild house miceRunge, J-NL, Anna K., Proceedings of the Royal Society B: Biological Sciences, 285:20181333. 2018.
Life is built on cooperation between genes, which makes it vulnerable to parasitism. Selfish genetic elements that exploit this cooperation can achieve large fitness gains by increasing their transmission relative to the rest of the genome. This leads to counter-adaptations that ... |
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Rats join mosquitoes as targets for ‘gene drive’ pest control.Hirschler, B, Reuters, 2017.
Rodents have joined mosquitoes in the cross-hairs of scientists working on a next-generation genetic technology known as “gene drive” to control pests.; Researchers in Scotland said on Tuesday they had developed two different ways to disrupt female fertility in rats and mice, ... |
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Open, Local, and ObligatedYale University, , 2017.
Kevin Esvelt, PhD, assistant professor at the MIT Media Lab and leader of the Sculpting Evolution Group talks about the need for new scientific structures based on transparency and open. This lecture was given at the 2017 Editing Nature Summit. |
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Could genetic engineering save the Galapagos?S. S. Hall, Scientific American, 2017.
Campbell has been working on eradications in the Galápagos since 1997, including a 2006 campaign to remove all the feral goats and donkeys from Floreana. A decade later he’s a project manager with Island Conservation, and the most ambitious project on its agenda is once again ... |
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How Genetically Modified Mice Could One Day Save Island BirdsBorel, B, Audubon, 2017.
The silent black-and-white footage opens on a seemingly tranquil setting: a burrow where an Atlantic Petrel tends to its chick. Then mice begin scurrying in and out of frame. The dark blurs jostle the adult, darting up to the exposed chick and tearing off bloody bites. They’re ... |
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Re-Coding for ConservationHawkes, A, Bay Nature Magazine, 2016.
very year, as summer turns to fall, the mouse population on the South Farallon Islands explodes to plague-like densities, numbering 490 mice per acre, among the highest found on any island in the world. The scientists who live and work there describe the assault of the invasive ... |
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No evidence for female discrimination against male house mice carrying a selfish genetic elementSutter, AL, A. K., Current Zoology, 62:675-685. 2016.
Meiotic drivers distort transmission to the next generation in their favor, with detrimental effects on the fitness of their homologues and the rest of the genome. Male carriers of meiotic drivers commonly inflict costs on their mates through genetic incompatibility, reduced ... |
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Meiotic drive changes sperm precedence patterns in house mice: potential for male alternative mating tactics?Sutter, AL, A. K., BMC Evolutionary Biology, 16:15. 2016.
Background: With female multiple mating (polyandry), male-male competition extends to after copulation (sperm competition). Males respond to this selective pressure through physiological, morphological and behavioural adaptations. Sperm competitiveness is commonly decreased in ... |
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The Trojan Female Technique for pest control: a candidate mitochondrial mutation confers low male fertility across diverse nuclear backgrounds in Drosophila melanogasterD. K. Dowling, D. M. Tompkins and N. J. Gemmell, Evolutionary Applications, 8:8710880. 2015.
The Trojan Female Technique (TFT) was recently proposed as a prospective approach to biological pest control. However, applicability of the TFT relies on mitochondrial mutations whose male-sterilizing effects are general across nuclear genomic contexts. We test this assumption, ... |
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Detrimental effects of an autosomal selfish genetic element on sperm competitiveness in house miceSutter, AL, A. K., Proceedings of the Royal Society B-Biological Sciences, 282:1-8. 2015.
Female multiple mating (polyandry) is widespread across many animal taxa and indirect genetic benefits are a major evolutionary force favouring polyandry. An incentive for polyandry arises when multiple mating leads to sperm competition that disadvantages sperm from genetically ... |
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Meiotic drive in mice carrying t-complex in their genomeSafronova, LDC, V. L., Russian Journal of Genetics, 49:885-897. 2013.
The deviation of alleles and chromosomes from Mendelian inheritance is characteristic of the meiotic drive. This review describes the mechanism in question using the best-studied example of transmitted ratio distortion in the heterozygous male mice carrying t-haplotypes. The ... |
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Maternal transmission ratio distortion at the mouse Om locus results from meiotic drive at the second meiotic divisionWu, GMH, L. P.; Han, Z. M.; Gao, S. R.; Latham, K. E.; de Villena, F. P. M.; Sapienza, C., Genetics, 170:327-334. 2005.
We have observed maternal transmission ratio distortion (TRD) in favor of DDK alleles at the Ovum mutant (Om) locus on mouse chromosome I I among the offspring of (C57BL/6 X DDK) F, females and C57BL/6 males. Although significant lethality occurs in this backcross (similar to ... |
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Physical mapping of male fertility and meiotic drive quantitative trait loci in the mouse t complex using chromosome deficienciesPlanchart, AY, Y.; Schimenti, J. C., Genetics, 155:803-812. 2000.
The t complex spans 20 cM of the proximal region of mouse chromosome 17. A variant form, the t haplotype (t), exists at significant frequencies in wild mouse populations and is characterized by the presence of inversions that suppress recombination with Mild-type (+) chromosomes. ... |
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Segregation distortion in unstructured and structured populations: Competition between ‘sterile’ t haplotypesVanBoven, MW, F. J., Netherlands Journal of Zoology, 46:216-226. 1996.
By means of two simple models we investigate the competition between sex-specific segregation distorters in unstructured and structured populations. The models are motivated by the t complex of the house mouse. Some variants at this gene complex, the t haplotypes, distort ... |
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Competition between segregation distorters: Coexistence of ”superior” and ”inferior” haplotypes at the t complexvanBoven, MW, F. J.; Heg, D.; Huisman, J., Evolution, 50:2488-2498. 1996.
By means of population genetical models, we investigate the competition between sex-specific segregation distorters. Although the models are quite general, they are motivated by a specific example, the t complex of the house mouse. Some variants at this gene complex, the t ... |
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Meiotic drive in female mice: An essayRuvinsky, A, Mammalian Genome, 6:315-320. 1995.
Since the rediscovery of Mendel's laws, geneticists have accumulated various examples in which equal meiotic segregation in heterozygotes is violated. However, only a few natural meiotic drive systems have been characterized in detail and the majority of these are sex chromosome ... |
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Meiotic drive of t haplotypes: chromosome segregation in mice with tertiary trisomyAgulnik, AIA, Sergei I.; Ruvinsky, Anatoly O., Genetics Research, 57:51. 1991.
The properties of the / haplotypes, specific mutant states of the proximal region of chromosomes17 in the house mouse, are of continuing interest. One such property is increased transmission ofthe / haplotype by heterozygous // + males to offspring. Using ... |
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Studies of the genetic variability in populations of wild house mice .2. Analysis of eight additional alleles at locus – TL. C. Dunn, Genetics, 42:299-311. 1957.1 Eight additional lethal alleles at locus T are described, each derived from a wild heterozygote in one of six different wild populations. 2. The frequency of heterozygotes appears to be high in most wild populations, possibly as high as 50 percent. 3. In two of the ... |
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Sur la reproduction des souris anouresN. Dobrovolskaia-Zavadskaia and N. Kobozieff, Comptes rendus des séances de la Société de biologie et de ses filiales, 97:116-119. 1927.
Nous ne connaissons que deux lignees de Souris sans queue, celle de Lang (1913), et cell de Duboscq (1922). L’elevange de Lang (lignee des Souris brachyures et anoures du preparateur Alfred Nageli) a donne 199 Souris normales, pour 173 brachyures et 9 anoures. Croisses entre ... |
