Keywords: monitoring
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Simple, sensitive, and cost-effective detection of wAlbB Wolbachia in Aedes mosquitoes, using loop mediated isothermal amplification combined with the electrochemical biosensing methodP. Thayanukul, B. Lertanantawong, W. Sirawaraporn, S. Charasmongkolcharoen, T. Chaibun, R. Jittungdee and P. Kittayapong, PLOS Neglected Tropical Diseases, 16:e0009600. 2022.
Author summary Mosquito-borne diseases such as dengue, chikungunya, zika, and yellow fever are transmitted to humans mainly by the bites of Aedes aegypti mosquitoes. Controlling the vectors of these diseases relies mostly on the use of insecticides. However, the efficiency has ... |
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Monitoring Needs for Gene Drive Mosquito Projects: Lessons From Vector Control Field Trials and Invasive SpeciesG. Rašić, N. F. Lobo, E. H. Jeffrey Gutiérrez, C. H. Sánchez and J. M. Marshall, Frontiers in Genetics, 12:780327. 2022.
As gene drive mosquito projects advance from contained laboratory testing to semi-field testing and small-scale field trials, there is a need to assess monitoring requirements to: i) assist with the effective introduction of the gene drive system at field sites, and ii) detect ... |
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Decision and Analysis Tools for Complex ProblemsHector Quemada and David O'Brochta, GeneConvene Global Collaborative, 2021.
The challenges associated with the multiple phases of testing and possible deployment of gene drive-containing organisms appear to have similarities to those associated with various aspects of invasive species management. Preventing unwanted spread of the target species as well ... |
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Invasive Species Management: Informing Gene Drive ConsiderationsDavid O'Brochta and Hector Quemada, GeneConvene Global Collaborative, 2021.
The management, control and elimination of invasive species involves solving problems that have analogs to those anticipating the use of gene drive technologies to control and eliminate malaria in Africa. Avoiding unintended consequences from interventions designed to reduce or ... |
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Risk management recommendations for environmental releases of gene drive modified insectsY. Devos, J. D. Mumford, M. B. Bonsall, D. C. M. Glandorf and H. D. Quemada, Biotechnology Advances, 2021.
The ability to engineer gene drives (genetic elements that bias their own inheritance) has sparked enthusiasm and concerns. Engineered gene drives could potentially be used to address long-standing challenges in the control of insect disease vectors, agricultural pests and ... |
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INSIDER: alignment-free detection of foreign DNA sequencesA. P. Tay, B. Hosking, C. Hosking, D. C. Bauer and L. O. W. Wilson, Computational and Structural Biotechnology Journal, 19:3810-3816. 2021.
External DNA sequences can be inserted into an organism’s genome either through natural processes such as gene transfer, or through targeted genome engineering strategies. Being able to robustly identify such foreign DNA is a crucial capability for health and biosecurity ... |
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Further guidance required for assessment of gene drive technology, says EFSAN. Foote, Euractiv, 2020.
After being mandated by the European Commission, EFSA’s experts on genetically modified organisms (GMOs) published the scientific opinion related to engineered gene drives on Thursday (12 November), specifically focusing on gene drive modified disease-transmitting insects, ... |
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Adequacy and sufficiency evaluation of existing EFSA guidelines for the molecular characterisation, environmental risk assessment and post-market environmental monitoring of genetically modified insects containing engineered gene drivesE. Panel o. G. M. Organisms, H. Naegeli, J.-L. Bresson, T. Dalmay, I. C. Dewhurst, M. M. Epstein, P. Guerche, J. Hejatko, F. J. Moreno, E. Mullins, F. Nogué, N. Rostoks, J. J. Sánchez Serrano, G. Savoini, E. Veromann, F. Veronesi, M. B. Bonsall, J. Mumfor, EFSA Journal, 18:e06297. 2020.
As a proactive measure, the European Food Safety Authority (EFSA) has been requested by the European Commission to review whether its previously published guidelines for the risk assessment of genetically modified animals (EFSA, 2012 and 2013), including insects (GMIs), are ... |
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EFSA advises on risk assessment of engineered gene drivesEFSA, European Food and Safety Authority, 2020.
EFSA’s existing guidelines for the risk assessment of genetically modified animals are adequate for evaluating risks associated with gene drive modified insects. However, further guidance is needed for some areas, such as molecular characterisation, environmental risk ... |
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Identifying and detecting potentially adverse ecological outcomes associated with the release of gene-drive modified organismsHayes, KRH, G. R.; Dana, G. V.; Foster, S. D.; Ford, J. H.; Thresher, R.; Ickowicz, A.; Peel, D.; Tizard, M.; De Barro, P.; Strive, T.; Dambacher, J. M., Journal of Responsible Innovation, 5:S139-S158. 2018.
Synthetic gene drives could provide new solutions to a range of old problems such as controlling vector-borne diseases, agricultural pests and invasive species. In this paper, we outline methods to identify hazards and detect potentially adverse ecological outcomes at the ... |
