Population-level multiplexing: A promising strategy to manage the evolution of resistance against gene drives targeting a neutral locusM. P. Edgington, T. Harvey-Samuel and L. Alphey, Evolutionary Applications, 10. 2020.
CRISPR-based gene drives bias inheritance in their favour by inducing double-stranded breaks (DSBs) at wild-type homologous loci and using the drive transgene as a repair template-converting drive heterozygotes into homozygotes. Recent studies have shown that alternate ...
Keywords: Cas 9, CRISPR, drive resistance, gene drive models, gene drive synthetic, Genetic engineering, multiplexing, Population genetics