mutagenic chain-reaction - GeneConvene Virtual Institute

Keywords: mutagenic chain-reaction

Gene drives do not always increase in frequency: from genetic models to risk assessment

de Jong, TJ, Journal Fur Verbraucherschutz Und Lebensmittelsicherheit-Journal of Consumer Protection and Food Safety, 12:299-307. 2017.

Homing genes encode endonucleases that make a double stranded break in the DNA, destroying a target site on the homologous chromosome. When the cell repairs the break the homing allele is copied, converting a heterozygote into a homozygote. This results in gene drive (GD), an ...
Keywords: Aedes aegypti, CRISPR-Cas system, drive, dual-use concerns, gene drive reviews, gene drive synthetic, genetically-modified mosquitos, Genetics & Heredity, homing endonuclease genes, human malaria, insects, life-shortening wolbachia, meiotic, mosquito, mutagenic chain-reaction, sex-ratio

Cheating evolution: engineering gene drives to manipulate the fate of wild populations

Champer, JB, A.; Akbari, O. S., Nature Reviews Genetics, 17:146-159. 2016.

Engineered gene drives - the process of stimulating the biased inheritance of specific genes - have the potential to enable the spread of desirable genes throughout wild populations or to suppress harmful species, and may be particularly useful for the control of vector-borne ...
Keywords: Aedes aegypti, CRISPR-Cas system, drive, dual-use concerns, gene drive reviews, gene drive synthetic, genetically-modified mosquitos, Genetics & Heredity, homing endonuclease genes, human malaria, insects, life-shortening wolbachia, meiotic, mosquito, mutagenic chain-reaction, sex-ratio