Keywords: mutagenic chain-reaction

Gene drives do not always increase in frequency: from genetic models to risk assessment

de Jong, TJ,  Journal Fur Verbraucherschutz Und Lebensmittelsicherheit-Journal of Consumer Protection and Food Safety,  12:299-307. 2017.
Homing genes encode endonucleases that make a double stranded break in the DNA, destroying a target site on the homologous chromosome. When the cell repairs the break the homing allele is copied, converting a heterozygote into a homozygote. This results in gene drive (GD), an ...
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Cheating evolution: engineering gene drives to manipulate the fate of wild populations

Champer, JB, A.; Akbari, O. S.,  Nature Reviews Genetics,  17:146-159. 2016.
Engineered gene drives - the process of stimulating the biased inheritance of specific genes - have the potential to enable the spread of desirable genes throughout wild populations or to suppress harmful species, and may be particularly useful for the control of vector-borne ...
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