
Keywords: other drive
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Gene drive and resilience through renewal with next generation Cleave and Rescue selfish genetic elementsOberhofer, G., T. Ivy and B. A. Hay, bioRxiv, 2019:2019.2012.2013.876169. 2019.![]() Gene drive-based strategies for modifying populations face the problem that genes encoding cargo and the drive mechanism are subject to separation, mutational inactivation, and loss of efficacy. Resilience, an ability to respond to these eventualities in ways that restore ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Killing two bugs with one stone: a perspective for targeting multiple pest species by incorporating reproductive interference into sterile insect techniqueHonma, AK, N.; Noriyuki, S., Pest Management Science, 75:571-577. 2019.![]() The sterile insect technique is an environmentally friendly method to control and even eradicate agricultural and veterinary insect pests without using chemical pesticides in excess. However, the continuous production and release of sterile insects is economically costly and ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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A genetic system for biasing the sex ratio in miceYosef, IEB, Liat; Globus, Rea; Shlomovitz, Inbar; Munitz, Ariel; Gerlic, Motti; Qimron, Udi, EMBO reports, 20:e48269. 2019.![]() Biasing the sex ratio of populations of different organisms, including plants, insects, crustacean, and fish, has been demonstrated by genetic and non-genetic approaches. However, biasing the sex ratio of mammalian populations has not been demonstrated genetically. Here, we ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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A large gene family in fission yeast encodes spore killers that subvert Mendel’s lawHu, WJ, Z. D.; Suo, F.; Zheng, J. X.; He, W. Z.; Du, L. L., eLife, 6:e28567. 2017.![]() Spore killers in fungi are selfish genetic elements that distort Mendelian segregation in their favor. It remains unclear how many species harbor them and how diverse their mechanisms are. Here, we discover two spore killers from a natural isolate of the fission yeast ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Intragenomic conflict produces sex ratio dynamics that favor maternal sex ratio distortersRood, ESF, S., Ecology and Evolution, 6:8085-8093. 2016.![]() Maternal sex ratio distorters (MSDs) are selfish elements that enhance their transmission by biasing their host's sex allocation in favor of females. While previous models have predicted that the female-biased populations resulting from sex ratio distortion can benefit from ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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A meiotic drive element in the maize pathogen Fusarium verticillioides is located within a 102 kb region of chromosome VPyle, JP, T.; Merrill, B.; Nsokoshi, C.; McCall, M.; Proctor, R. H.; Brown, D. W.; Hammond, T. M., G3-Genes Genomes Genetics, 6:2543-2552. 2016.![]() Fusarium verticillioides is an agriculturally important fungus because of its association with maize and its propensity to contaminate grain with toxic compounds. Some isolates of the fungus harbor a meiotic drive element known as Spore killer (Sk(K)) that causes nearly all ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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R2d2 drives selfish sweeps in the house mouseDidion, JPM, A. P.; Yadgary, L.; Bell, T. A.; McMullan, R. C.; de Solorzano, L. O.; Britton-Davidian, J.; Bult, C. J.; Campbell, K. J.; Castiglia, R.; Ching, Y. H.; Chunco, A. J.; Crowley, J. J.; Chesler, E. J.; Forster, D. W.; French, J. E.; Gabriel, S. I.; Gatti, D. M.; Garland, T.; Giagia-Athanasopoulou, E. B.; Gimenez, M. D.; Grize, S. A.; Gunduz, I.; Holmes, A.; Hauffe, H. C.; Herman, J. S.; Holt, J. M.; Hua, K. J.; Jolley, W. J.; Lindholm, A. K.; Lopez-Fuster, M. J.; Mitsainas, G.; Mathias, M. D.; McMillan, L.; Ramalhinho, M. D. M.; Rehermann, B.; Rosshart, S. P.; Searle, J. B.; Shiao, M. S.; Solano, E.; Svenson, K. L.; Thomas-Laemont, P.; Threadgill, D. W.; Ventura, J.; Weinstock, G. M.; Pomp, D.; Churchill, G. A.; de Villena, F. P. M., Molecular Biology and Evolution, 33:1381-1395. 2016.![]() A selective sweep is the result of strong positive selection driving newly occurring or standing genetic variants to fixation, and can dramatically alter the pattern and distribution of allelic diversity in a population. Population-level sequencing data have enabled discoveries ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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The next generation of rodent eradications: Innovative technologies and tools to improve species specificity and increase their feasibility on islandsCampbell, KJB, J.; Eason, C. T.; Glen, A. S.; Godwin, J.; Gould, F.; Holmes, N. D.; Howald, G. R.; Madden, F. M.; Ponder, J. B.; Threadgill, D. W.; Wegmann, A. S.; Baxter, G. S., Biological Conservation, 185:47-58. 2015.![]() Rodents remain one of the most widespread and damaging invasive alien species on islands globally. The current toolbox for insular rodent eradications is reliant on the application of sufficient anticoagulant toxicant into every potential rodent territory across an island. ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Confinement of gene drive systems to local populations: A comparative analysisMarshall, JMH, B. A., Journal of Theoretical Biology, 294:153-171. 2012.![]() Mosquito-borne diseases such as malaria and dengue fever pose a major health problem through much of the world. One approach to disease prevention involves the use of selfish genetic elements to drive disease-refractory genes into wild mosquito populations. Recently engineered ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulenceBustos, ON, S.; Ayers, G.; Casola, C.; Perez-Lamigueiro, M. A.; Chippindale, P. T.; Pritham, E. J.; de la Casa-Esperon, E., Gene, 447:11-Jan. 2009.![]() Genes of the Schlafen family, first discovered in mouse, are expressed in hematopoietic cells and are involved in immune processes. Previous results showed that they are candidate genes for two major phenomena: meiotic drive and embryonic lethality (DDK syndrome). However, these ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Inverted meiosis and meiotic drive in mealybugsBongiorni, SF, P.; Pippoletti, D.; Prantera, G., Chromosoma, 112:331-341. 2004.![]() In the males of lecanoid coccids, or mealybugs, an entire, paternally derived, haploid chromosome set becomes heterochromatic after the seventh embryonic mitotic cycle. In females, both haploid sets are euchromatic throughout the life cycle. In mealybugs, as in all homopteran ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Nonrandom segregation during meiosis: the unfairness of femalesde Villena, FPMS, C., Mammalian Genome, 12:331-339. 2001.![]() Most geneticists assume that chromosome segregation during meiosis is Mendelian (i.e., each allele at each locus is represented equally in the gametes). The great majority of reports that discuss non-Mendelian transmission have focused on systems of gametic selection, such as the ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Transmission ratio distortion due to the bl gene in table beetAustin, DG, I. L., Journal of the American Society for Horticultural Science, 126:340-343. 2001.![]() The bl gene conditions a blotchy phenotype (irregular sectors of red and white root color) in table beet (Beta vulgaris ssp, vulgaris). Segregation of the bl gene was found to be consistent with a single recessive gene, however, some evidence for a departure from a single gene ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Invasion of one insect species, Adalia bipunctata, by two different male-killing bacteriaHurst, GDDvdS, J. H. G.; Majerus, T. M. O.; Bertrand, D.; Zakharov, I. A.; Baungaard, J.; Volkl, W.; Stouthamer, R.; Majerus, M. E. N., Insect Molecular Biology, 8:133-139. 1999.![]() Male-killing bacteria, which are inherited through the female line and kill male progeny only, are known from five different orders of insect. Our knowledge of the incidence of these elements has stemmed from discovery of their phenotype in different species, Our estimate of the ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Transmission ratio distortion at the INS-IGF2 VNTREaves, IAB, S. T.; Forster, P.; Ferber, K. M.; Ehrmann, D.; Wilson, A. J.; Bhattacharyya, S.; Ziegler, A. G.; Brinkmann, B.; Todd, J. A., Nature Genetics, 22:324-325. 1999.![]() Transmission ratio distortion (TRD) is defined as a statistically significant departure from mendelian transmission. So far, evidence of this in humans has been limited or controversial1,2,3,4, and the few established examples involve chromosome rearrangements in lower ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Meiotic drive of chromosomal knobs reshaped the maize genomeBuckler, ESP-D, T. L.; Buckler, C. S. K.; Dawe, R. K.; Doebley, J. F.; Holtsford, T. P., Genetics, 153:415-426. 1999.![]() Meiotic drive is the subversion of meiosis so that particular genes are preferentially transmitted to the progeny. Meiotic drive generally causes the preferential segregation of small regions of the genome; however, in maize we propose that meiotic drive is responsible for the ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Sex ratio distortion in Acraea encedon (Lepidoptera : Nymphalidae) is caused by a male-killing bacteriumJiggins, FMH, G. D. D.; Majerus, M. E. N., Heredity, 81:87-91. 1998.![]() Females of the butterfly Acraea encedon produce either entirely female offspring or males and females in an almost 1:1 sex ratio. The sex ratio produced is maternally inherited and was previously attributed to sex chromosome meiotic drive. We report that all-female lineages are ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Selfish genes and meiotic driveHurst, LD, Nature, 391:223-223. 1998.![]() Work by Gerald Wilkinson and colleagues3 on stalk-eyed flies (Diopsidae), described on page 276, provides the strongest evidence to date about the nature of some of the genes females prefer. As their name suggests, stalk-eyed flies have their eyes perched on the end of ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Wolbachia as a possible means of driving genes into populationsCurtis, CFS, S. P., Parasitology, 116:S111-S115. 1998.![]() Cytoplasmic incompatibility consists of sterility in cross matings, the crossing type being maternally inherited. It can be explained by the action of Wolbachia symbionts which are transmitted through the egg cytoplasm and leave an imprint on the sperm which prevents it ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Segregation distortion of the CTG repeats at the myotonic dystrophy locusChakraborty, RS, D. N.; Deka, R.; Yu, L. M.; Shriver, M. D.; Ferrell, R. E., American Journal of Human Genetics, 59:109-118. 1996.![]() Myotonic dystrophy (DM), an autosomal dominant neuromuscular disease, is caused by a CTG-repeat expansion, with affected individuals having greater than or equal to 50 repeats of this trinucleotide, at the DMPK locus of human chromosome 19q13.3. Severely affected individuals die ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Meiotic drive an Myotonic Dystrophy – ReplyCarey, NJ, K.; Nokelainen, P.; Peltonen, L.; Savontaus, M. L.; Juvonen, V.; Anvret, M.; Grandell, U.; Chotai, K.; Robertson, E.; Middletonprice, H.; Malcolm, S., Nature Genetics, 10:133-133. 1995.![]() Myotonic dystrophy (DM) is a trinucleotide disorder and in sub-clinical individuals there is considerable variation in the length of the CTG repeat. Two groups have recently analysed the patterns of segregation of different sized alleles at this locus and both report an excess of ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Meiotic drive at the Myotonic Dystrophy locusCarey, NJ, K.; Nokelainen, P.; Peltonen, L.; Savontaus, M. L.; Juvonen, V.; Anvret, M.; Grandell, U.; Chotai, K.; Robertson, E.; Middletonprice, H.; Malcolm, S., Nature Genetics, 6:117-118. 1994.![]() Myotonic dystrophy (DM) is the most common form of adult muscular dystrophy (average incidence 1 in 8,000) 1 • It is an autosomal dominant trait with multisystemic involvement and marked clinical variability. Anticipation, in which symptom severity increases and age of onset ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Meiotic drive on aberrant Chromosome-1 in the mouse is determined by a linked distorterAgulnik, SIS, I. D.; Orlova, G. V.; Ruvinsky, A. O., Genetical Research, 61:91-96. 1993.![]() An aberrant chromosome 1 carrying an inverted fragment with two amplified DNA regions was isolated from wild populations of Mus musculus. Meiotic drive favouring the aberrant chromosome was demonstrated for heterozygous females. Its cause was preferential passage of aberrant ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Meiotic drive for the aberrant Chromosome-1 in mice is determined by a linked distorterAgulnik, SIS, I. D.; Orlova, G. V.; Ruvinsky, A. O., Genetika, 28:47-57. 1992.![]() AN aberrant chromosome 1 carrying an inverted fragment with two amplified DNA regions was isolated from natural populations of Mus musculus. A meiotic drive favouring the aberrant chromosome was previously demonstrated for heterozygous females. The cause for this was the ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Segregation distortersLyttle, TW, Annual Review of Genetics, 25:511-557. 1991.![]() Segregation distorters are genetic elements that exhibit the phenomenon of meiotic drive; that is, the mechanics of the meiotic divisions cause one member of a pair of heterozygous alleles or heteromorphic chromosomes to be transmitted to progeny in excess of the expected ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Meiotic drive in female mice heterozygous for the HSR inserts on Chromosome-1Agulnik, SIA, A. I.; Ruvinsky, A. O., Genetical Research, 55:97-100. 1990.![]() Chromosome 1 with one or two long insertions has been previously found in natural mouse populations. The inheritance of chromosome 1 with two insertions from the Yakutsk population is analysed in this paper. It was demonstrated that heterozygous females transmit this chromosome ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Meiotic drive of the aberrant Chromosome-1 in the house mouseAgulnik, SIA, A. I.; Ruvinsky, A. O., Genetika, 26:664-669. 1990.![]() Animals with aberrant chromosome 1 carrying one or two large insertions were earlier described in natural populations of Mus musculus. In the present work, inheritance of the aberrant chromosome 1 from the Yakutsk population was investigated. It was shown that 80-85% of the ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Genetics-driving genes and chromosomesCharlesworth, B, Nature, 332:394-395. 1988.![]() Thereare several genetic and chromosomal systems in which Mendel's first law - the equal probability of transmission of maternal and paternal alternative alleles or homologues - is violated. This phenomenon was named 'meiotic drive' in 1957 by Sandler and Novitski, who drew ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |
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Methods for replacement of malaria vector populationsCurtis, CFG, P. M., American Journal of Tropical Medicine and Hygiene, 91:43-48. 1988.![]() The prospects are reviewed of replacement of malaria vector populations by harmless mosquito populations by means of: (i) ecologically competitive non-vector species; (ii) natural selection due to the harmfulness of being infected; (iii) selection for insecticide resistance ... Keywords: gene drive evolution, gene drive natural, mammals, other drive |

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David O’Brochta
Foundation for the
National Institutes of Health
geneconvenevi@fnih.org
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