Genetic Variation and Potential for Resistance Development to the tTA Overexpression Lethal System in InsectsK. E. Knudsen, W. R. Reid, T. M. Barbour, L. M. Bowes, J. Duncan, E. Philpott, S. Potter and M. J. Scott, G3: Genes|Genomes|Genetics, Early Online:g3.400990.2020. 2020.
Release of insect pests carrying the dominant lethal tetracycline transactivator (tTA) overexpression system has been proposed as a means for population suppression. High levels of the tTA transcription factor are thought to be toxic due to either transcriptional squelching or ...
Keywords: autocidal control, drosophila, overexpression, Oxitec, resistance, SIT, sterile insect technique, tTA