Keywords: paratransgenesis

Sexual transmission of Anopheles gambiae densovirus (AgDNV) leads to disseminated infection in mated females

K. L. Werling, R. M. Johnson, H. C. Metz and J. L. Rasgon,  Parasites and Vectors,  15:219. 2022.
Anopheles gambiae densovirus (AgDNV) is an insect-specific, single-stranded DNA virus that infects An. gambiae sensu stricto (s.s.), the major mosquito species responsible for transmitting malaria parasites throughout sub-Saharan Africa. AgDNV is a benign virus that is very ...
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New weapons to fight malaria transmission: A historical view

W. Huang, S.-J. Cha and M. Jacobs-Lorena,  Entomological Research,  2022.
The stagnation of our fight against malaria in recent years, mainly due to the development of mosquito insecticide resistance, argues for the urgent development of new weapons. The dramatic evolution of molecular tools in the last few decades led to a better understanding of ...
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Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors

N. A. Ratcliffe, J. P. Furtado Pacheco, P. Dyson, H. C. Castro, M. S. Gonzalez, P. Azambuja and C. B. Mello,  Parasites and Vectors,  15:112. 2022.
This article presents an overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. It first briefly summarises some of the disease-causing pathogens vectored by insects and emphasises the need for innovative control methods to counter the ...
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A natural symbiotic bacterium drives mosquito refractoriness to Plasmodium infection via secretion of an antimalarial lipase

H. Gao, L. Bai, Y. M. Jiang, W. Huang, L. L. Wang, S. G. Li, G. D. Zhu, D. Q. Wang, Z. H. Huang, X. S. Li, J. Cao, L. B. Jiang, M. Jacobs-Lorena, S. Zhan and S. B. Wang,  Nature Microbiology,  25. 2021.
The stalling global progress in the fight against malaria prompts the urgent need to develop new intervention strategies. Whilst engineered symbiotic bacteria have been shown to confer mosquito resistance to parasite infection, a major challenge for field implementation is to ...
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Engineering a Culturable Serratia symbiotica Strain for Aphid Paratransgenesis

K. M. Elston, J. Perreau, G. P. Maeda, N. A. Moran and J. E. Barrick,  Applied Environmental Microbiology,  87. 2020.
Aphids are global agricultural pests and important models for bacterial symbiosis. To date, none of the native symbionts of aphids have been genetically manipulated, which limits our understanding of how they interact with their hosts. Serratia symbiotica CWBI-2.3(T) is a ...
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The Evolving Arsenal Against Mosquito-Born Diseases

J. Smith,  Labiotech.eu,  2020.
As the global climate continues to warm, disease-spreading mosquitoes such as Aedes aegypti are expected to establish themselves in the US and Europe.
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Prospects and Pitfalls: Next-Generation Tools to Control Mosquito-Transmitted Disease

E. P. Caragata, S. Dong, Y. Dong, M. L. Simões, C. V. Tikhe and G. Dimopoulos,  Annual Review of Microbiology,  74:455-475. 2020.
A diverse array of next-generation tools has been designed to eliminate mosquito populations or to replace them with mosquitoes that are less capable of transmitting key pathogens.
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Mosquito-Borne Diseases Emergence/Resurgence and How to Effectively Control It Biologically

H. Dahmana and O. Mediannikov,  Pathogens,  9:26. 2020.
Deadly pathogens and parasites are transmitted by vectors and the mosquito is considered the most threatening vector in public health, transmitting these pathogens to humans and animals. We are currently witnessing the emergence/resurgence in new regions/populations of the most ...
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Engineered symbionts activate honey bee immunity and limit pathogens

P. Leonard Sean, J. E. Powell, J. Perutka, P. Geng, C. Heckmann Luke, D. Horak Richard, W. Davies Bryan, D. Ellington Andrew, E. Barrick Jeffrey and A. Moran Nancy,  Science,  367:573-576. 2020.
Honey bees are essential pollinators threatened by colony losses linked to the spread of parasites and pathogens. Here, we report a new approach for manipulating bee gene expression and protecting bee health. We engineered a symbiotic bee gut bacterium, Snodgrassella alvi, to ...
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RSPM No. 27 Guidelines for Importation and Confined Field Release of Transgenic Arthropods in NAPPO Member Countries

NAPPPO,  NAPPO Regional Standards for Phytosanitary Measures,  2007.
This Standard is designed to provide guidance to NAPPO member countries on the importation and confined field release of transgenic arthropods that are known plant pests or have the potential to affect plant health. This includes transgenic arthropods used for biological control ...
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