Keywords: paratransgenesis

A natural symbiotic bacterium drives mosquito refractoriness to Plasmodium infection via secretion of an antimalarial lipase

H. Gao, L. Bai, Y. M. Jiang, W. Huang, L. L. Wang, S. G. Li, G. D. Zhu, D. Q. Wang, Z. H. Huang, X. S. Li, J. Cao, L. B. Jiang, M. Jacobs-Lorena, S. Zhan and S. B. Wang,  Nature Microbiology,  25. 2021.
The stalling global progress in the fight against malaria prompts the urgent need to develop new intervention strategies. Whilst engineered symbiotic bacteria have been shown to confer mosquito resistance to parasite infection, a major challenge for field implementation is to ...
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Engineering a Culturable Serratia symbiotica Strain for Aphid Paratransgenesis

K. M. Elston, J. Perreau, G. P. Maeda, N. A. Moran and J. E. Barrick,  Applied Environmental Microbiology,  87. 2020.
Aphids are global agricultural pests and important models for bacterial symbiosis. To date, none of the native symbionts of aphids have been genetically manipulated, which limits our understanding of how they interact with their hosts. Serratia symbiotica CWBI-2.3(T) is a ...
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The Evolving Arsenal Against Mosquito-Born Diseases

J. Smith,  Labiotech.eu,  2020.
As the global climate continues to warm, disease-spreading mosquitoes such as Aedes aegypti are expected to establish themselves in the US and Europe.
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Prospects and Pitfalls: Next-Generation Tools to Control Mosquito-Transmitted Disease

E. P. Caragata, S. Dong, Y. Dong, M. L. Simões, C. V. Tikhe and G. Dimopoulos,  Annual Review of Microbiology,  74:455-475. 2020.
A diverse array of next-generation tools has been designed to eliminate mosquito populations or to replace them with mosquitoes that are less capable of transmitting key pathogens.
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Mosquito-Borne Diseases Emergence/Resurgence and How to Effectively Control It Biologically

H. Dahmana and O. Mediannikov,  Pathogens,  9:26. 2020.
Deadly pathogens and parasites are transmitted by vectors and the mosquito is considered the most threatening vector in public health, transmitting these pathogens to humans and animals. We are currently witnessing the emergence/resurgence in new regions/populations of the most ...
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Engineered symbionts activate honey bee immunity and limit pathogens

P. Leonard Sean, J. E. Powell, J. Perutka, P. Geng, C. Heckmann Luke, D. Horak Richard, W. Davies Bryan, D. Ellington Andrew, E. Barrick Jeffrey and A. Moran Nancy,  Science,  367:573-576. 2020.
Honey bees are essential pollinators threatened by colony losses linked to the spread of parasites and pathogens. Here, we report a new approach for manipulating bee gene expression and protecting bee health. We engineered a symbiotic bee gut bacterium, Snodgrassella alvi, to ...
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RSPM No. 27 Guidelines for Importation and Confined Field Release of Transgenic Arthropods in NAPPO Member Countries

NAPPPO,  NAPPO Regional Standards for Phytosanitary Measures,  2007.
This Standard is designed to provide guidance to NAPPO member countries on the importation and confined field release of transgenic arthropods that are known plant pests or have the potential to affect plant health. This includes transgenic arthropods used for biological control ...
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