Keywords: remediation
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Engineering a self-eliminating transgene in the yellow fever mosquito, Aedes aegyptiK. Chae, C. Dawson, C. Valentin, B. Contreras, J. Zapletal, K. M. Myles and Z. N. Adelman, PNAS Nexus, 2022.
Promising genetics-based approaches are being developed to reduce or prevent the transmission of mosquito-vectored diseases. Less clear is how such transgenes can be removed from the environment, a concern that is particularly relevant for highly invasive gene drive transgenes. ... |
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UC San Diego Biology Lab Receives $1.4M Grant to Fight Malaria SpreadE. Dameron, UC San Diego News Center, 2022.
Scientists at the University of California San Diego are hard at work on new genetic technologies intended for use in curbing mosquito populations, fighting the spread of malaria and mitigating the hazards associated with the deployment of gene-editing systems in the wild. That ... |
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Making gene drive biodegradableJ. Zapletal, N. Najmitabrizi, M. Erraguntla, M. A. Lawley, K. M. Myles and Z. N. Adelman, Philosophical Transactions of the Royal Society B: Biological Sciences, 376:20190804. 2020.
Here, we consider the inclusion of self-elimination mechanisms into the design of homing-based gene drive transgenes. This approach not only caused the excision of the gene drive transgene, but also generates a transgene-free allele resistant to further action by the gene drive. ... |
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Gene Drive Control Worry Eased by Genetic Neutralizing ElementsStaff, Genetic Engineering and Biotechnology News, 2020.
Bier and his colleagues have developed two new active genetic systems that address such risks by halting or eliminating gene drives in the wild, offering two new solutions based on elements developed in the common fruit fly. T |
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Active Genetic Neutralizing Elements for Halting or Deleting Gene DrivesX.-R. S. Xu, E. A. Bulger, V. M. Gantz, C. Klanseck, S. R. Heimler, A. Auradkar, J. B. Bennett, L. A. Miller, S. Leahy, S. S. Juste, A. Buchman, O. S. Akbari, J. M. Marshall and E. Bier, Molecular Cell, 2020.
Here we describe two self-copying (or active) guide RNA-only genetic elements, called e-CHACRs and ERACRs. These elements use Cas9 produced in trans by a gene drive either to inactivate the cas9 transgene (e-CHACRs) or to delete and replace the gene drive (ERACRs). |
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Biologists create new genetic systems to neutralize gene drivesUniversity of California San Diego, ScienceDaily, 2020.
Now, scientists at the University of California San Diego and their colleagues have developed two new active genetic systems that address such risks by halting or eliminating gene drives in the wild. |
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Chemical controllable gene drive in DrosophilaD. Chae, J. Lee, N. Lee, K. Park, S. J. Moon and H. H. Kim, ACS Synthetic Biology, in press. 2020.
Here, we report a chemical-induced control of gene drive. We prepared a CRISPR-based gene drive system that can be removed by a site-specific recombinase, Rippase, the expression of which is induced by the chemical RU486 in fruit flies. Exposure of fruit flies to RU486 resulted ... |
