Keywords: remediation

Making gene drive biodegradable

J. Zapletal, N. Najmitabrizi, M. Erraguntla, M. A. Lawley, K. M. Myles and Z. N. Adelman,  Philosophical Transactions of the Royal Society B: Biological Sciences,  376:20190804. 2020.
Here, we consider the inclusion of self-elimination mechanisms into the design of homing-based gene drive transgenes. This approach not only caused the excision of the gene drive transgene, but also generates a transgene-free allele resistant to further action by the gene drive. ...
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Gene Drive Control Worry Eased by Genetic Neutralizing Elements

Staff,  Genetic Engineering and Biotechnology News,  2020.
Bier and his colleagues have developed two new active genetic systems that address such risks by halting or eliminating gene drives in the wild, offering two new solutions based on elements developed in the common fruit fly. T
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Active Genetic Neutralizing Elements for Halting or Deleting Gene Drives

X.-R. S. Xu, E. A. Bulger, V. M. Gantz, C. Klanseck, S. R. Heimler, A. Auradkar, J. B. Bennett, L. A. Miller, S. Leahy, S. S. Juste, A. Buchman, O. S. Akbari, J. M. Marshall and E. Bier,  Molecular Cell,  2020.
Here we describe two self-copying (or active) guide RNA-only genetic elements, called e-CHACRs and ERACRs. These elements use Cas9 produced in trans by a gene drive either to inactivate the cas9 transgene (e-CHACRs) or to delete and replace the gene drive (ERACRs).
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Biologists create new genetic systems to neutralize gene drives

University of California San Diego,  ScienceDaily,  2020.
Now, scientists at the University of California San Diego and their colleagues have developed two new active genetic systems that address such risks by halting or eliminating gene drives in the wild.
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Chemical controllable gene drive in Drosophila

D. Chae, J. Lee, N. Lee, K. Park, S. J. Moon and H. H. Kim,  ACS Synthetic Biology,  in press. 2020.
Here, we report a chemical-induced control of gene drive. We prepared a CRISPR-based gene drive system that can be removed by a site-specific recombinase, Rippase, the expression of which is induced by the chemical RU486 in fruit flies. Exposure of fruit flies to RU486 resulted ...
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