
Keywords: RIDL
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Self-limiting fall armyworm: a new approach in development for sustainable crop protection and resistance managementC. E. Reavey, A. S. Walker, S. P. Joyce, L. Broom, A. Willse, K. Ercit, M. Poletto, Z. H. Barnes, T. Marubbi, B. J. Troczka, D. Treanor, K. Beadle, B. Granville, V. de Mello, J. Teal, E. Sulston, A. Ashton, L. Akilan, N. Naish, O. Stevens, N. Humphreys-Jo, BMC Biotechnology, 22:5. 2022.![]() Here, we describe the first germline transformation of the fall armyworm and the development of a genetically engineered male-selecting self-limiting strain, OX5382G, which exhibits complete female mortality in the absence of an additive in the larval diet. Laboratory experiments ... Keywords: gene drive synthetic, genetic biocontrol, genetically modified, GMO, IIT, mosquito, Oxitec, policy, regulation, RIDL, risk, sterile insect technique, wolbachia |
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Monitoring Needs for Gene Drive Mosquito Projects: Lessons From Vector Control Field Trials and Invasive SpeciesG. Rašić, N. F. Lobo, E. H. Jeffrey Gutiérrez, C. H. Sánchez and J. M. Marshall, Frontiers in Genetics, 12:780327. 2022.![]() As gene drive mosquito projects advance from contained laboratory testing to semi-field testing and small-scale field trials, there is a need to assess monitoring requirements to: i) assist with the effective introduction of the gene drive system at field sites, and ii) detect ... Keywords: gene drive synthetic, genetic biocontrol, genetically modified, GMO, IIT, mosquito, Oxitec, policy, regulation, RIDL, risk, sterile insect technique, wolbachia |
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Oxitec Advances Process to Bring Friendly™ Mosquito Technology to California to Help Government Agencies Protect Public HealthOxitec, Oxitec, 2021.![]() Following successful launch of its Friendly™ Aedes aegypti pilot program in the Florida Keys, Oxitec, the leading developer of biological solutions to control pests that transmit disease, destroy crops and harm livestock, has requested approval from the U.S. Environmental ... Keywords: gene drive synthetic, genetic biocontrol, genetically modified, GMO, IIT, mosquito, Oxitec, policy, regulation, RIDL, risk, sterile insect technique, wolbachia |
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Engineered expression of the invertebrate-specific scorpion toxin AaHIT reduces adult longevity and female fecundity in the diamondback moth Plutella xylostellaT. Harvey-Samuel, X. Xu, E. Lovett, T. Dafa'alla, A. Walker, V. C. Norman, R. Carter, J. Teal, L. Akilan, P. T. Leftwich, C. M. Reitmayer, H. A. Siddiqui and L. Alphey, Pest Management Science, 2021.![]() To increase the flexibility of future genetic pest management systems in the diamondback moth, we aimed to assess the use of a non-cell-autonomous, invertebrate-specific, neurotoxic effector ? the scorpion toxin AaHIT. This AaHIT effector was designed to be secreted by ... Keywords: gene drive synthetic, genetic biocontrol, genetically modified, GMO, IIT, mosquito, Oxitec, policy, regulation, RIDL, risk, sterile insect technique, wolbachia |
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EPA Approves Genetically Modified Mosquito Trial For Florida KeysNancy Klingener, WLRN, 2020.![]() A plan to test genetically modified mosquitoes in the Florida Keys has received approval from the federal government. Keywords: gene drive synthetic, genetic biocontrol, genetically modified, GMO, IIT, mosquito, Oxitec, policy, regulation, RIDL, risk, sterile insect technique, wolbachia |
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EPA Grants First Permit to Test Genetically Modified MosquitoesAdam Allington, Bloomberg Law, 2020.![]() British biotech company Oxitec Ltd was granted an experimental use permit to release a genetically engineered type of the mosquito species Aedes aegypti, which is a known vector of Zika virus and viruses that cause yellow fever and dengue fever, the Environmental Protection ... Keywords: gene drive synthetic, genetic biocontrol, genetically modified, GMO, IIT, mosquito, Oxitec, policy, regulation, RIDL, risk, sterile insect technique, wolbachia |
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EPA Approves Experimental Use Permit to Test Innovative Biopesticide Tool to Better Protect Public HealthEPA, EPA, 2020.![]() Today, after extensive evaluation of the best available science and public input, the U.S. Environmental Protection Agency (EPA) has granted an experimental use permit (EUP) to Oxitec Ltd. to field test the use of genetically engineered Aedes aegypti mosquitoes as a way to reduce ... Keywords: gene drive synthetic, genetic biocontrol, genetically modified, GMO, IIT, mosquito, Oxitec, policy, regulation, RIDL, risk, sterile insect technique, wolbachia |
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Genetic Control of MosquitoesAlphey, L., Annual Review of Entomology, 59:205-224. 2019.![]() Genetics can potentially provide new, species-specific, environmentally friendly methods for mosquito control. Genetic control strategies aim either to suppress target populations or to introduce a harm-reducing novel trait. Different approaches differ considerably in their ... Keywords: gene drive synthetic, genetic biocontrol, genetically modified, GMO, IIT, mosquito, Oxitec, policy, regulation, RIDL, risk, sterile insect technique, wolbachia |
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A secret weapon against Zika and other mosquito-borne diseasesNina Federoff, TEDxMidAtlantic, 2017.![]() Where did Zika come from, and what can we do about it? Molecular biologist Nina Fedoroff takes us around the world to understand Zika's origins and how it spread, proposing a controversial way to stop the virus -- and other deadly diseases -- by preventing infected mosquitoes ... Keywords: gene drive synthetic, genetic biocontrol, genetically modified, GMO, IIT, mosquito, Oxitec, policy, regulation, RIDL, risk, sterile insect technique, wolbachia |
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SCIENTIFIC OPINION: In response to the referral of 12 October 2015 concerning use of genetically modified mosquitoes for vector controlHigh Council for Biotechnology, High Council for Biotechnology (France), 2017.![]() The Scientific Committee’s opinion describes emerging vector control techniques using GM mosquitoes, the current state of research into and development of these techniques and the outcomes of initial experiments worldwide. To date, only one technique has been developed to an ... Keywords: gene drive synthetic, genetic biocontrol, genetically modified, GMO, IIT, mosquito, Oxitec, policy, regulation, RIDL, risk, sterile insect technique, wolbachia |
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Concept and history of genetic controlScott, M. J. and Benedict, M. Q., Genetic Control of Malaria and Dengue, 2:31-54. 2016.![]() Genetic control of insects is an established method, mainly for insects that are important crop and veterinary pests such as medflies and screwworm. Efforts to use the same technologies against insects of medical importance, especially mosquitoes, have had limited success. The ... Keywords: gene drive synthetic, genetic biocontrol, genetically modified, GMO, IIT, mosquito, Oxitec, policy, regulation, RIDL, risk, sterile insect technique, wolbachia |
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Genetic Control of Mosquitoes.Alphey, L., Annual Review of Entomology, 59:205-224. 2014.![]() Genetics can potentially provide new, species-specific, environmentally friendly methods for mosquito control. Genetic control strategies aim either to suppress target populations or to introduce a harm-reducing novel trait. Different approaches differ considerably in their ... Keywords: gene drive synthetic, genetic biocontrol, genetically modified, GMO, IIT, mosquito, Oxitec, policy, regulation, RIDL, risk, sterile insect technique, wolbachia |
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Field performance of engineered male mosquitoesA. F. Harris, D. Nimmo, A. R. McKemey, N. Kelly, S. Scaife, C. A. Donnelly, C. Beech, W. D. Petrie and L. Alphey, Nature Biotechnology, 29:1034-1037. 2011.![]() Mass-release of sterile male mosquitoes is a promising option for controlling dengue and malaria, but it has never been shown that lab-raised transgenic males can compete effectively with their wild counterparts outside laboratory conditions. Promising results from a restricted ... Keywords: gene drive synthetic, genetic biocontrol, genetically modified, GMO, IIT, mosquito, Oxitec, policy, regulation, RIDL, risk, sterile insect technique, wolbachia |
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Field performance of engineered male mosquitoesA. F. Harris, D. Nimmo, A. R. McKemey, N. Kelly, S. Scaife, C. A. Donnelly, C. Beech, W. D. Petrie and L. Alphey, Nature Biotechnology, 29:1034-1037. 2011.![]() Mass-release of sterile male mosquitoes is a promising option for controlling dengue and malaria, but it has never been shown that lab-raised transgenic males can compete effectively with their wild counterparts outside laboratory conditions. Promising results from a restricted ... Keywords: gene drive synthetic, genetic biocontrol, genetically modified, GMO, IIT, mosquito, Oxitec, policy, regulation, RIDL, risk, sterile insect technique, wolbachia |

Contact
David O’Brochta
Foundation for the
National Institutes of Health
geneconvenevi@fnih.org
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