Chemical controllable gene drive in DrosophilaD. Chae, J. Lee, N. Lee, K. Park, S. J. Moon and H. H. Kim, ACS Synthetic Biology, in press. 2020.
Here, we report a chemical-induced control of gene drive. We prepared a CRISPR-based gene drive system that can be removed by a site-specific recombinase, Rippase, the expression of which is induced by the chemical RU486 in fruit flies. Exposure of fruit flies to RU486 resulted ...
Keywords: chemical control, control, drosophila, gene drive synthetic, melanogaster, remediation, reversal, Rippase, RU486, synthetic homing drive
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