
Keywords: segregation distorter
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“Selfish Genetic Elements” – Supergene Wreaks Havoc in a GenomeUniversity of Rochester, SciTechDaily, 2022.![]() “Selfish genetic elements” litter the human genome. They do not seem to benefit their hosts but instead seek only to propagate themselves. These selfish genetic elements can wreak havoc. For example, they can distort sex ratios, impair fertility, cause harmful mutations, and ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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What can we learn from selfish loci that break Mendel’s law?S. E. Zanders, PLOS Biology, 20:e3001700. 2022.![]() Mendel’s law of segregation provides a critical foundation for genetic inquiry It is not, however, without exceptions Historically, 2 such exceptions (sex chromosome linkage and chromosome missegregation in meiosis) were used by Drosophila geneticists to help demonstrate ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Epistatic selection on a selfish Segregation Distorter supergene: drive, recombination, and genetic loadB. Navarro-Dominguez, C.-H. Chang, C. L. Brand, C. A. Muirhead, D. C. Presgraves and A. M. Larracuente, eLife, 11:e78981. 2022.![]() In this work, we investigate the evolution and genomic consequences of an autosomal, multilocus, male meiotic drive system, Segregation Distorter (SD) in the fruit fly, Drosophila melanogaster. In African populations, the predominant SD chromosome variant, SD-Mal, is ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Sexual selection can partly explain low frequencies of Segregation Distorter allelesT. A. Keaney, T. M. Jones and L. Holman, Proceedings of the Royal Society B: Biological Sciences, 288:20211190. 2021.![]() The Segregation Distorter (SD) allele found in Drosophila melanogaster distorts Mendelian inheritance in heterozygous males by causing developmental failure of non-SD spermatids, such that greater than 90% of the surviving sperm carry SD. This within-individual advantage should ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Distinct spermiogenic phenotypes underlie sperm elimination in the Segregation Distorter meiotic drive systemM. Herbette, X. L. Wei, C. H. Chang, A. M. Larracuente, B. Loppin and R. Dubruille, PLOS Genetics, 17:26. 2021.![]() Here we show that SD/SD+ males of different genotypes but with similarly strong degrees of distortion have distinct spermiogenic phenotypes. In some genotypes, SD+ spermatids fail to fully incorporate protamines after the removal of histones, and degenerate during the ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Maternal Transmission Ratio Distortion in Two Iberian Pig VarietiesM. Vazquez-Gomez, M. M. de Hijas-Villalba, L. Varona, N. Ibanez-Escriche, J. P. Rosas, S. Negro, J. L. Noguera and J. Casellas, Genes, 11:16. 2020.![]() Although TRD can be a confounding factor in genetic mapping studies, this phenomenon remains mostly unknown in pigs, particularly in traditional breeds (i.e., the Iberian pig). We aimed to describe the maternal TRD prevalence and its genomic distribution in two Iberian varieties. ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Analysis of a Strong Suppressor of Segregation Distorter inDrosophila melanogasterR. G. Temin, Genetics, 215:1085-1105. 2020.![]() These studies highlight the polygenic nature of distortion and its dependence on a constellation of positive and negative modifiers, provide insight into the stability of Mendelian transmission in natural populations even when a drive system arises, and pave the way for molecular ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Meiotic driveA. N. Srinivasa and S. E. Zanders, Current Biology, 30:R627-R629. 2020.![]() What is meiotic drive? Diploid organisms, like you, have two copies of each autosomal chromosome, one from each parent. Sometimes organisms are heterozygous at a given region, meaning they carry different copies (or alleles) of the DNA sequence on the two homologous chromosomes. ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Gene drive: Evolved and syntheticBurt, AC, Andrea, ACS Chemical Biology, 13:343-346. 2018.![]() Drive is a process of accelerated inheritance from one generation to the next that allows some genes to spread rapidly through populations even if they do not contribute to—or indeed even if they detract from—organismal survival and reproduction. Genetic elements that can ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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The promise and peril of CRISPR gene drivesZentner, GEW, Michael J. C., Bioessays, 39:1-9. 2017.![]() Gene drives are selfish genetic elements that use a variety of mechanisms to ensure they are transmitted to subsequent generations at greater than expected frequencies. Synthetic gene drives based on the clustered regularly interspersed palindromic repeats (CRISPR) genome editing ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Intragenomic conflict produces sex ratio dynamics that favor maternal sex ratio distortersRood, ESF, S., Ecology and Evolution, 6:8085-8093. 2016.![]() Maternal sex ratio distorters (MSDs) are selfish elements that enhance their transmission by biasing their host's sex allocation in favor of females. While previous models have predicted that the female-biased populations resulting from sex ratio distortion can benefit from ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Origin, evolution, and population genetics of the selfish Segregation Distorter gene duplication in European and African populations of Drosophila melanogasterBrand, CLL, A. M.; Presgraves, D. C., Evolution, 69:1271-1283. 2015.![]() Meiotic drive elements are a special class of evolutionarily selfish genes that subvert Mendelian segregation to gain preferential transmission at the expense of homologous loci. Many drive elements appear to be maintained in populations as stable polymorphisms, their equilibrium ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Presence of segregation distortion in sheepRaed, MA, Research Journal of Biotechnology, 10:87-98. 2015.![]() The main objective of this project was the investigation of presence of segregation distortion (SD) and description of other relevant parameters of multilocus genetics in Australian Merino sheep. The SD cases investigated three flocks of 98, 79 and 92 offspring and their ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Segregation distortion affected by transgenes in early generations of rice crop-weed hybrid progeny: Implications for assessing potential evolutionary impacts from transgene flow into wild relativesYang, CW, Z.; Yang, X.; Lu, B. R., Journal of Systematics and Evolution, 52:466-476. 2014.![]() The significant role of segregation distortion as a driving force of evolution has increasingly gained recognition worldwide. Segregation distortion of parental alleles is commonly reported in hybrid progeny between crops and wild relative species, which possibly influences the ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Meiotic drive influences the outcome of sexually antagonistic selection at a linked locusPatten, MM, Journal of Evolutionary Biology, 27:2360-2370. 2014.![]() Most meiotic drivers, such as the t-haplotype in Mus and the segregation distorter (SD) in Drosophila, act in a sex-specific manner, gaining a transmission advantage through one sex although suffering only the fitness costs associated with the driver in the other. Their ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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The organization and evolution of the Responder satellite in species of the Drosophila melanogaster group: dynamic evolution of a target of meiotic driveLarracuente, AM, BMC Evolutionary Biology, 14:233. 2014.![]() : Satellite DNA can make up a substantial fraction of eukaryotic genomes and has roles in genome structure and chromosome segregation. The rapid evolution of satellite DNA can contribute to genomic instability and genetic incompatibilities between species. Despite its ubiquity ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Mutations to the piRNA Pathway Component Aubergine Enhance Meiotic Drive of Segregation Distorter in Drosophila melanogasterGell, SLR, R. A., Genetics, 193:771-784. 2013.![]() Diploid sexual reproduction involves segregation of allelic pairs, ensuring equal representation of genotypes in the gamete pool. Some genes, however, are able to "cheat" the system by promoting their own transmission. The Segregation distorter (Sd) locus in Drosophila ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Mechanism of meiotic drive in mammalsChmatal, LF, K.; Schultz, R. M.; Lampson, M. A., Molecular Biology of the Cell, 24:3775. 2013.![]() Meiotic drive is a phenomenon responsible for an unequal representation of alleles or whole chromosomes among gametes as a result of the mechanics of meiotic division (Sandler et Novitski 1957). When it drives segregation of Robertsonian translocations (Rb), a common chromosomal ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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The Selfish Segregation Distorter Gene Complex of Drosophila melanogasterLarracuente, AMP, D. C., Genetics, 192:33-53. 2012.![]() Segregation Distorter (SD) is an autosomal meiotic drive gene complex found worldwide in natural populations of Drosophila melanogaster. During spermatogenesis, SD induces dysfunction of SD+ spermatids so that SD/SD+ males sire almost exclusively SD-bearing progeny rather than ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Molecular dissection of Neurospora Spore killer meiotic drive elementsHammond, TMR, D. G.; Xiao, H.; Shiu, P. K. T., Proceedings of the National Academy of Sciences of the United States of America, 109:12093-12098. 2012.![]() Meiotic drive is a non-Mendelian inheritance phenomenon in which certain selfish genetic elements skew sexual transmission in their own favor. In some cases, progeny or gametes carrying a meiotic drive element can survive preferentially because it causes the death or ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Segregation distortion and the evolution of sex-determining mechanismsKozielska, MW, F. J.; Beukeboom, L. W.; Pen, I., Heredity, 104:100-112. 2010.![]() Segregation distorters are alleles that distort normal segregation in their own favour. Sex chromosomal distorters lead to biased sex ratios, and the presence of such distorters, therefore, may induce selection for a change in the mechanism of sex determination. The evolutionary ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Molecular signature of epistatic selection: interrogating genetic interactions in the sex-ratio meiotic drive of Drosophila simulansChevin, LMB, H.; Montchamp-Moreau, C.; Hospital, F., Genetics Research, 91:171-182. 2009.![]() Fine scale analyses Of signatures of selection allow assessing quantitative aspects of a Species' evolutionary genetic history, such as the strength of selection on genes. When several selected loci lie in the same genomic region, their epistatic interactions may also be ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Large-scale selective sweep among Segregation Distorter chromosomes in African populations Drosophila melanogasterPresgraves, DCG, P. R.; Cherukuri, A.; Lyttle, T. W., PLOS Genetics, 5:e1000463. 2009.![]() Segregation Distorter (SD) is a selfish, coadapted gene complex on chromosome 2 of Drosophila melanogaster that strongly distorts Mendelian transmission; heterozygous SD/SD(+) males sire almost exclusively SD-bearing progeny. Fifty years of genetic, molecular, and theory work ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Defects in nuclear transport enhance segregation distortionMcElroy, JMM, R. A.; McLean, J. R., Fly, 2:280-290. 2008.![]() The equal segregation of chromosomes into gametes is a central tenet of Mendelian genetics. It is this process that is responsible for generating predictable outcomes of crosses, as well as subjecting all chromosomes to the natural selective pressures that exert themselves on a ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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A sex-ratio meiotic drive system in Drosophila simulans. I: An autosomal suppressorTao, YM, J. P.; Araripe, L.; Ke, Y.; Hartl, D. L., PLOS Biology, 5:2560-2575. 2007.![]() Sex ratio distortion (sex-ratio for short) has been reported in numerous species such as Drosophila, where distortion can readily be detected in experimental crosses, but the molecular mechanisms remain elusive. Here we characterize an autosomal sex-ratio suppressor from D. ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Identification and characterization of segregation distortion loci along chromosome 5B in tetraploid wheatKumar, SG, B. S.; Faris, J. D., Molecular Genetics and Genomics, 278:187-196. 2007.![]() Segregation distortion genes are widespread in plants and animals and function by their effect on competition among gametes for preferential fertilization. In this study, we evaluated the segregation distortion of molecular markers in multiple reciprocal backcross populations ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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The hitchhiking effect of an autosomal meiotic drive geneChevin, LMH, F., Genetics, 173:1829-1832. 2006.![]() Transmission-ratio distortion is a departure from a 1:1 segregation of alleles in the gametes of a heterozygous individual. The so-called driving allele is strongly selected regardless of its effect on the fitness of the carrying individual. It may then have an important impact ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Segregation distortion in Arabidopsis C24/Col-0 and Col-0/C24 recombinant inbred line populations is due to reduced fertility caused by epistatic interaction of two lociTorjek, OW-W, H.; Meyer, R. C.; von Korff, M.; Kusterer, B.; Rautengarten, C.; Altmann, T., Theoretical and Applied Genetics, 113:1551-1561. 2006.![]() A new large set of reciprocal recombinant inbred lines (RILs) was created between the Arabidopsis accessions Col-0 and C24 for quantitative trait mapping approaches, consisting of 209 Col-0 x C24 and 214 C24 x Col-0 F-7 RI lines. Genotyping was performed using 110 evenly ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Meiotic drive at the Om locus in wild-derived inbred mouse strainsKim, KT, S.; Howard, I. B.; Bell, T. A.; Doherty, H. E.; Ideraabdullah, F.; Detwiler, D. A.; De Villena, F. P. M., Biological Journal of the Linnean Society, 84:487-492. 2005.![]() Meiotic drive is an evolutionary force in which natural selection is uncoupled from organismal fitness. Recently, it has been proposed that meiotic drive and genetic drift represent major forces in the evolution of the mammalian karyotype. Meiotic drive involves two types of ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Reinvestigation of an endogenous meiotic drive system in the mosquito, Aedes aegypti (Diptera : Culicidae)Mori, AC, D. D.; Graham, D. H.; Severson, D. W., Journal of Medical Entomology, 41:1027-1033. 2004.![]() We have initiated efforts to determine the molecular basis for the M-D meiotic drive system in the mosquito, Aedes aegypti. The effect of the M-D gene is a highly male-biased sex ratio, but varies depending on the frequency and sensitivity of a susceptible responder m(s) allele. ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Common features of segregation distortion in plants and animalsTaylor, DRI, P. K., Genetica, 117:27-35. 2003.![]() Segregation distortion is increasingly recognized as a potentially powerful evolutionary force. This runs counter to the perception that non-Mendelian genes are rare genetic curiosities, a view that seems to be supported by the near ubiquity of the Mendelian system of ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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The aging effect in the segregation distorter system of Drosophila melanogasterOh, SCN, J. G., Korean Journal of Genetics, 25:237-242. 2003.![]() The SD/SD+ heterozygous male of Drosophila melanogaster transmits the SD second chromosome to its progeny in excess of the Mendelian frequency of 0.5. The k value is defined as the frequency of the SD chromosome recovered among progeny from such a male. This value has been shown ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Closing the (Ran)GAP on segregation distortion in DrosophilaKusano, AS, C.; Chan, H. Y. E.; Ganetzky, B., Bioessays, 25:108-115. 2003.![]() Segregation Distorter (SD) is a meiotic drive system in Drosophila that causes preferential transmission of the SD chromosome from SD/SD+ males owing to induced dysfunction of SD+ spermatids. Since its discovery in 1956, SD and its mode of action have baffled biologists. ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Responder (Rsp) alleles in the Segregation Distorter (SD) system of meiotic drive in Drosophila may represent a complex family of satellite repeat sequencesHoutchens, KL, T. W., Genetica, 117:291-302. 2003.![]() In D. melanogaster males carrying Segregation Distorter (SD) second chromosomes, sperm receiving sensitive alleles of the Responder (Rsp) locus are subject to high rates of dysfunction. The Rsp region is located in 2R immediately adjacent to the centromere in heterochromatic band ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Sperm competition and the dynamics of X chromosome drive: Stability and extinctionTaylor, JEJ, J., Genetics, 160:1721-1731. 2002.![]() Several empirical studies of sperm competition in populations polymorphic for a driving X chromosome have revealed that Sex-ratio males (those carrying a driving X) are at a disadvantage relative to Standard males. Because the frequency of the driving X chromosome determines the ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Segregation distortion induced by wild-type RanGAP in DrosophilaKusano, AS, C.; Ganetzky, B., Proceedings of the National Academy of Sciences of the United States of America, 99:6866-6870. 2002.![]() Segregation Distorter (SD) is a meiotic drive system in Drosophila that causes preferential transmission of the SD chromosome from SD/SD+ males owing to the induced dysfunction of SD+ spermatids. The key distorter locus, Sid, is a dominant neomorphic allele encoding a truncated, ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Sperm development, age and sex chromosome meiotic drive in the stalk-eyed fly, Cyrtodiopsis whiteiWilkinson, GSS, M. I., Heredity, 87:17-24. 2001.![]() The cytological basis of X chromosome meiotic drive or sex ratio (SR) has been reported for several species of Drosophila but not for other species. Here we describe how sperm development in the stalk-eyed fly, Cyrtodiopsis whitei, influences progeny sex proportion, in order to ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Selection and segregation distortion in a sex-differentiated populationWeissing, FJvB, M., Theoretical Population Biology, 60:327-341. 2001.![]() We extend the classical model for selection at an autosomal locus in a sex-differentiated population to include segregation distortion. The equations remain the same, but the fitness parameters are interpreted differently and refer to alleles instead of genotypes. We derive ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Sex-ratio segregation distortion associated with reproductive isolation in DrosophilaTao, YH, D. L.; Laurie, C. C., Proceedings of the National Academy of Sciences of the United States of America, 98:13183-13188. 2001.![]() Sex-ratio distortion is the most common form of non-Mendelian segregation observed in natural populations. It may occur even more frequently than direct observations suggest, because the dysgenic population consequences of a biased sex ratio are expected to result in the rapid ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Nonrandom segregation during meiosis: the unfairness of femalesde Villena, FPMS, C., Mammalian Genome, 12:331-339. 2001.![]() Most geneticists assume that chromosome segregation during meiosis is Mendelian (i.e., each allele at each locus is represented equally in the gametes). The great majority of reports that discuss non-Mendelian transmission have focused on systems of gametic selection, such as the ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Heritability of the maternal meiotic drive system linked to Om and high-resolution mapping of the Responder locus in mousede Villena, FPMdlC-E, E.; Williams, J. W.; Malette, J. M.; Rosa, M.; Sapienza, C., Genetics, 155:283-289. 2000.![]() Matings between (C57BL/6 X DDK)F-1 females and C57BL/6 males result in a significant excess of offspring inheriting maternal DDK alleles in the central region of mouse chromosome 11 due to meiotic drive at the second meiotic division. We have shown previously that the locus ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Transmission ratio distortion in females on chromosome 10p11-p15Paterson, ADP, A., American Journal of Medical Genetics, 88:657-661. 1999.![]() A number of recent reports of linkage of markers on chromosome 10p to schizophrenia, and evidence for linkage in one study to bipolar affective disorder, provide encouragement for psychiatric genetics, after nonreplication of linkage findings at other chromosomal regions, The ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Truncated RanGAP encoded by the Segregation Distorter locus of DrosophilaMerrill, CB, L.; Kusano, A.; Ganetzky, B., Science, 283:1742-1745. 1999.![]() Segregation Distorter (SD) in Drosophila melanogaster is a naturally occurring meiotic drive system in which the SD chromosome is transmitted from SD/SD+ males in vast: excess over its homolog owing to the induced dysfunction of SD+-bearing spermatids. The Sd Locus is the key ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Segregation distortion in a deme structured population: opposing demands of gene, individual and group selectionvan Boven, MW, F. J., Journal of Evolutionary Biology, 12:80-93. 1999.![]() The evolution of segregation distortion is governed by the interplay of selection at different levels. Despite their systematic advantage at the gamete level, none of the well-known segregation distorters spreads to fixation since they induce severe negative fitness effects at ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Evolution of segregation distortion: Potential for a high degree of polymorphismvan Boven, MW, F. J., Journal of Theoretical Biology, 192:131-142. 1998.![]() By means of a population genetical model, we study the evolution of segregation distortion. Most models of segregation distortion focus on a single distorter allele. In contrast, we consider the competition between a large number of distorters. Motivated by systems as the t ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Selfish genes and meiotic driveHurst, LD, Nature, 391:223-223. 1998.![]() Work by Gerald Wilkinson and colleagues3 on stalk-eyed flies (Diopsidae), described on page 276, provides the strongest evidence to date about the nature of some of the genes females prefer. As their name suggests, stalk-eyed flies have their eyes perched on the end of ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Segregation distortion in unstructured and structured populations: Competition between ‘sterile’ t haplotypesVanBoven, MW, F. J., Netherlands Journal of Zoology, 46:216-226. 1996.![]() By means of two simple models we investigate the competition between sex-specific segregation distorters in unstructured and structured populations. The models are motivated by the t complex of the house mouse. Some variants at this gene complex, the t haplotypes, distort ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Epistatic control of non-mendelian inheritance in mouse interspecific crossesMontagutelli, XT, R.; Nadeau, J. H., Genetics, 143:1739-1752. 1996.![]() Strong deviation of allele frequencies from Mendelian inheritance favoring Mus spretus-derived alleles has been described previously for X-linked loci in four mouse interspecific crosses. We reanalyzed data for three of these crosses focusing on the location of the gene(s) ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Characterization of 2 Segregation Distorter revertants: Evidence that the tandem duplication is necessary for SD activity in Drosophila melanogasterPalopoli, MFD, P.; Wu, C. I., Genetics, 136:209-215. 1994.![]() Segregation Distorter (SD) is a naturally occurring system of meiotic drive in Drosophila melanogaster. Males heterozygous for an SD second chromosome and a normal homolog (SD+) transmit predominantly SD-bearing sperm. To accomplish this, the Segregation distorter (Sd) locus ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Functional identification of the Segregation Distorter locus of Drosophila melanogaster by germline transformationMcLean, JRM, C. J.; Powers, P. A.; Ganetzky, B., Genetics, 137:201-209. 1994.![]() Segregation Distorter (SD) is a meiotic drive system in D. melanogaster that results in the failure of SD/SD+ males to transmit SD+ homologs owing to the induced dysfunction of spermatids carrying the normal chromosome. Segregation distorter (Sd), the gene primarily responsible ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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The Segregation Distorter (SD) complex and the accumulation of deleterious genes in laboratory strains of Drosophila melanogasterDominguez, AS, E.; Albornoz, J.; Gutierrez, A., Theoretical and Applied Genetics, 87:479-486. 1993.![]() Segregation Distorter (SD) associated with the second chromosome of D. melanogaster is found in nature at equilibrium frequencies lower than 5%. We report extremely high frequencies of SD (30-50%) in two selected strains, established in 1976, and show it to be responsible for the ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Evolutionary dynamics of spore killersNauta, MJH, R. F., Genetics, 135:923-930. 1993.![]() Spore killing in ascomycetes is a special form of segregation distortion. When a strain with the Killer genotype is crossed to a Sensitive type, spore killing is expressed by asci with only half the number of ascospores as usual, all surviving ascospores being of the Killer type. ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Cheaters sometimes prosper: Distortion of Mendelian segregation by meiotic driveLyttle, TW, Trends in Genetics, 9:205-210. 1993.![]() Two of Mendel's three laws were quickly discarded as information on the organization and transmission of genes accumulated at the beginning of this century, but bis law of segregation has shown remarkable staying power. In fact, within most of population genetic theory for sexual ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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A comparative approach to the population genetics theory of segregation distortionFeldman, MWO, Sarah P., American Naturalist, 137:443-456. 1991.![]() Mathematical models of four well-known naturally occurring systems of segregation distortion are compared. These include the sex-ratio chromosome of Drosophila pseudoobscura, the Segregation Distorter (SD) complex of D. melanogaster, the t locus in Mus musculus, and the sex-ratio ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Why is Mendelian segregation so exactCrow, JF, Bioessays, 13:305-312. 1991.![]() The precise 1:1 segregation of Mendelian heredity is ordinarily taken for granted, yet there are numerous examples of 'cheating' genes that perpetuate themselves in the population by biasing the Mendelian process in their favor. One example is the Segregation Distortion system of ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Segregation distortion in Drosophila melanogaster: Genetic and molecular analysisTemin, RGG, B.; Powers, P. A.; Lyttle, T. W.; Pimpinelli, S.; Dimitri, P.; Wu, C. I.; Hiraizumi, Y., American Naturalist, 137:287-331. 1991.![]() The Segregation Distorter (SD) complex in the centromeric region of chromosome 2 in Drosophila melanogaster is responsible for a naturally occurring and strong system of male meiotic drive. Earlier recombinational dissection and deletional analysis showed that the SD complex ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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On the components of Segregation Distortion in Drosophila melanogaster 5: Molecular analysis of the SD locusPowers, PAG, B., Genetics, 129:133-144. 1991.![]() Segregation Distorter (SD) is a naturally occurring meiotic drive system comprising at least three distinct loci: Sd, Rsp and E(SD). Heterozygous SD/SD+ males transmit the SD chromosome in vast excess over the normal homolog. The distorted transmission involves the induced ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Segregation distortersLyttle, TW, Annual Review of Genetics, 25:511-557. 1991.![]() Segregation distorters are genetic elements that exhibit the phenomenon of meiotic drive; that is, the mechanics of the meiotic divisions cause one member of a pair of heterozygous alleles or heteromorphic chromosomes to be transmitted to progeny in excess of the expected ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Sander,Larry – The father of meiotic driveLindsley, DL, American Naturalist, 137:283-286. 1991.![]() The symposium at which the following papers were presented was deprived of what surely would have been a major intellectual contribution by the sudden death of its co-organizer, Larry Sandler, in February 1987. Larry was a leading contributor to the study of segregation ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Genetics-driving genes and chromosomesCharlesworth, B, Nature, 332:394-395. 1988.![]() Thereare several genetic and chromosomal systems in which Mendel's first law - the equal probability of transmission of maternal and paternal alternative alleles or homologues - is violated. This phenomenon was named 'meiotic drive' in 1957 by Sandler and Novitski, who drew ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Detection of Rsp and modifier variation in the meiotic drive system Segregation Distorter (SD) of Drosophila melanogasterLyttle, TWB, J. G.; Ganetzky, B., Genetics, 114:183-202. 1986.![]() Identification of allelic variability at the two major loci (Sd and Rsp) that interact to cause sperm dysfunction in Segregation distorter (SD) males of D. melanogaster has been hampered by the difficulty in separating the elements recombinationally. In addition, small ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Experimental population-genetics of meiotic drive systems .3: Neutralization of sex-ratio distortion in Drosophila through sex-chromosome aneuploidyLyttle, TW, Genetics, 98:317-334. 1981.![]() Laboratory populations of Drosophila melanogaster were challenged by; pseudo-Y drive, which mimics true Y-chromosome meiotic drive through the; incorporation of Segregation Distorter (SD) in a T(Y;2) complex. This causes; extreme sex-ratio distrotion and can ultimately lead to ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Experimental population-genetics of meiotic drive systems .2: Accumulation of genetic modifiers of Segregation Distorter (SD) in laboratory populationsLyttle, TW, Genetics, 91:339-357. 1979.![]() The accumulation of modifiers of the meiotic-drive locus Segregation; Distorter (SD) in Drosophila melanogaster was monitored by measuring the; changes in the mean and variance of drive strength (in terms of “make” value); that occur in laboratory populations when SD and SD+ ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Experimental population-genetics of meiotic drive systems .1: Pseudo-Y chromosomal drive as a means of eliminating cage populations of Drosophila melanogasterLyttle, TW, Genetics, 86:413-445. 1977.![]() The experimental population genetics of Y-chromosome drive in Drosophila; melanogasier is approximated by studying the behavior of T(Y;S),SD lines.; These exhibit “pseudo-Y” drive through the effective coupling of the Y chromosome; to the second chromosome meiotic drive ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Modifier theory of meiotic driveHartl, DL, Theoretical Population Biology, 7:168-174. 1975.![]() The evolutionary fate of rare modifiers of recessive lethal segregation distorters has been studied. Suppressors or partial suppressors will always increase in frequency. Enhancers will increase in frequency if linkage is sufficiently tight and be lost if linkage is sufficiently ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Multiple meiotic drive systems in Drosophila melanogaster maleMiklos, GLGY, A. F.; Peacock, W. J., Genetics, 72:105-115. 1972.![]() The behaviour of two "meiotic drive" systems, Segregation-Distorter (SD) and the sex chromosome sc4sc8 has been examined in the same meiocyte. It has been found that the two systems interact in a specific way. When the distorting effects of SD and sc4sc8 are against each other, ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Meiotic drive in natural populations of Drosophila melanogaster 9: Suppressors of segregation distorter in wild populationsHartl, DL, Canadian Journal of Genetics and Cytology, 12:594-600. 1970.![]() A population of Drosophila melanogaster in Madison, Wisconsin, has been screened for suppressors of segregation distorter (SD), an autosomal meiotic drive element found in the same population. Three kinds of suppressors were tested for: (1) Y-linked suppressors, none were found, ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Meiotic drive and visible polarity in Drosophila spermatocytesYanders, AFB, J. G.; Peacock, W. J.; Goodchild, D. J., Genetics, 59:245-253. 1968.![]() The model for meiotic drive presented by PEACOCK and ERICKSON (1965) demands that an intracellular differentiation exists at the time of the first meiotic division in spermatocytes. As a result of this differentiation, one of the spindle poles at anaphase I will lead to the ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Meiotic drive in natural populations of Drosophila melanogaster .7. Conditional segregation distortion – a possible nonallelic conversionSandler, LH, Y., Genetics, 46:585-604. 1961.![]() Males, heterozygous for the Segregation-distorter (SD) allele (located in or near the centromeric heterochromatin of the right arm of chromosome 11) and a standard tester second chromosome, regularly produce a preponderance of functional SD-bearing sperm ( SANDLER, HIRAIZUMI and ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Meiotic drive in natural populations of Drosophila melanogaster .8. A heritable aging effect on phenomenon of segregation distortionSandler, LH, Y., Canadian Journal of Genetics and Cytology, 3:34-46. 1961.![]() Second chromosomes have been found in natural populations of Drosophila melanogaster that contain an abnormal centromere region which conditions a highly aberrant segregation ratio in heterozygous males (Sandler, Hiraizumi, and Sandler, 1959). In particular, when a chromosome ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Meiotic drive in natural populations of Drosophila melanogaster .6: A preliminary report on presence of segregation-distortion in a Baja california populationMange, EJ, American Naturalist, 95:87-96. 1961.![]() Meiotic drive is a term coined by Sandler and Novitski (1957) to describe; the situation whereby a heterozygote produces gametes containing an excess; of one allele, rather than the expected equality. As a consequence of such; aberrant segregations, gene frequencies within a ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Meiotic drive in natural populations of Drosophila melanogaster .4: Instability at the Segregation Distorter locusSandler, LH, Y., Genetics, 45:1269-1287. 1960.![]() In a collection of flies from a natural population of Drosophila melanogaster, several second chromosomes have been isolated that contain, in the centromere region .of chromosome 11, a locus (named segregation-distorter and symbolized SO) that conditions, in heterozygous males, a ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Meiotic drive in natural populations of Drosophila melanogaster .5. On the nature of the SD regionSandler, LH, Y., Genetics, 45:1671-1689. 1960.![]() Second chromosomes were collected from nature which, when heterozygous with a normal chromosome 1 in males, are present in functional sperm much more often than the expected 50 percent. This phenomenon, named segregation distortion, was found to depend on a locus named ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Meiotic drive in natural-populations of Drosophila melanogaster 3: Populational implications of the Segregation-Distorter locusHiraizumi, YS, L.; Crow, J. E., Evolution, 14:433-444. 1960.![]() If, among the successful gametes frm heterozygotes, one allele is regularly included in more than half, it may increase in frequency even if it has a harmful effect. Unequal gamete production, when attributable to the mechanics of meiosis, has been called meiotic drive (Sandler ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Meiotic drive in natural populations of Drosophila melanogaster .1. The cytogenetic basis of segregation distortionSandler, LH, Y.; Sandler, I., Genetics, 44:233-250. 1959.![]() Meiotic drive has been defined as a force, potentially capable of altering gene frequencies in natural populations, which somehow depends upon the nature of the meiotic divisions; specifically, when the meiotic divisions are such that the two kinds of gametes from a heterozygote ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |
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Meiotic drive in natural populations of Drosophila melanogaster 2. Genetic variation at the Segregation Distorter locusSandler, LH, Y., Proceedings of the National Academy of Sciences of the United States of America, 45:1412-1422. 1959.![]() It has now been found that the proportion of heterozygous SD males resulting from any given cross which exhibits segregation-distortion, and the amount of distortion that any particular male shows (the k value), varies widely depending upon the precise source and history of the ... Keywords: Cas9, CRISPR, daisy drive, gene drive reviews, gene drive synthetic, homing endonucleases, segregation distorter |

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