Engineered Reciprocal Chromosome Translocations Drive High Threshold, Reversible Population Replacement in DrosophilaBuchman, ABI, Tobin; Marshall, John M.; Akbari, Omar S.; Hay, Bruce A., ACS Synthetic Biology, 7:1359-1370. 2018.
Replacement of wild insect populations with transgene-bearing individuals unable to transmit disease or survive under specific environmental conditions using gene drive provides a self-perpetuating method of disease prevention. Mechanisms that require the gene drive element and ...
Keywords: dengue, engineered translocations, Gene drive, gene drive genetics, gene drive synthetic, insects, malaria, mosquito, public acceptance, self-propagating, selfish genetic element, UDMEL, unbreakable, underdominance, vector control