Keywords: self-propagating

Engineered Reciprocal Chromosome Translocations Drive High Threshold, Reversible Population Replacement in Drosophila

Buchman, ABI, Tobin; Marshall, John M.; Akbari, Omar S.; Hay, Bruce A.,  ACS Synthetic Biology,  7:1359-1370. 2018.
Replacement of wild insect populations with transgene-bearing individuals unable to transmit disease or survive under specific environmental conditions using gene drive provides a self-perpetuating method of disease prevention. Mechanisms that require the gene drive element and ...
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