Keywords: selfish centromere
Meiotic drive of noncentromeric loci in mammalian meiosis II eggsD. M. Silva and T. Akera, Curr Opin Genet Dev, 81:102082. 2023.The germline produces haploid gametes through a specialized cell division called meiosis. In general, homologous chromosomes from each parent segregate randomly to the daughter cells during meiosis, providing parental alleles with an equal chance of transmission. Meiotic drivers ... Keywords: aneuploidy, chromosome drive, contromere drive, gene drive natural, mammals, selfish centromere |
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Selfish centromeres and the wastefulness of human reproductionL. D. Hurst, PLOS Biology, 20:e3001671. 2022.Many human embryos die in utero owing to an excess or deficit of chromosomes, a phenomenon known as aneuploidy; this is largely a consequence of nondisjunction during maternal meiosis I. Asymmetries of this division render it vulnerable to selfish centromeres that promote their ... Keywords: aneuploidy, chromosome drive, contromere drive, gene drive natural, mammals, selfish centromere |
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David O’Brochta
Foundation for the
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geneconvenevi@fnih.org
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