Keywords: selfish centromere

Meiotic drive of noncentromeric loci in mammalian meiosis II eggs

D. M. Silva and T. Akera,  Curr Opin Genet Dev,  81:102082. 2023.
The germline produces haploid gametes through a specialized cell division called meiosis. In general, homologous chromosomes from each parent segregate randomly to the daughter cells during meiosis, providing parental alleles with an equal chance of transmission. Meiotic drivers ...
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Selfish centromeres and the wastefulness of human reproduction

L. D. Hurst,  PLOS Biology,  20:e3001671. 2022.
Many human embryos die in utero owing to an excess or deficit of chromosomes, a phenomenon known as aneuploidy; this is largely a consequence of nondisjunction during maternal meiosis I. Asymmetries of this division render it vulnerable to selfish centromeres that promote their ...
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